Search Results - "Sesboüé, Richard"

Correlation between Density of CD8+ T-cell Infiltrate in Microsatellite Unstable Colorectal Cancers and Frameshift Mutations: A Rationale for Personalized Immunotherapy by Maby, Pauline, Tougeron, David, Hamieh, Mohamad, Mlecnik, Bernhard, Kora, Hafid, Bindea, Gabriela, Angell, Helen K, Fredriksen, Tessa, Elie, Nicolas, Fauquembergue, Emilie, Drouet, Aurélie, Leprince, Jérôme, Benichou, Jacques, Mauillon, Jacques, Le Pessot, Florence, Sesboüé, Richard, Tuech, Jean-Jacques, Sabourin, Jean-Christophe, Michel, Pierre, Frébourg, Thierry, Galon, Jérôme, Latouche, Jean-Baptiste

“…Colorectal cancers with microsatellite instability (MSI) represent 15% of all colorectal cancers, including Lynch syndrome as the most frequent hereditary form…”
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Follow-up of Bronchial Precancerous Lesions and Carcinoma in Situ Using Fluorescence Endoscopy by BOTA, SUZANA, AULIAC, JEAN-BERNARD, PARIS, CHRISTOPHE, METAYER, JOSETTE, SESBOUE, RICHARD, NOUVET, GEORGES, THIBERVILLE, LUC

“…Little is known about the natural history of precancerous bronchial lesions. Histological changes occurring in 416 bronchial intraepithelial lesions (104…”
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Metastatic colorectal cancer KRAS genotyping in routine practice: results and pitfalls by Lamy, Aude, Blanchard, France, Le Pessot, Florence, Sesboüé, Richard, Di Fiore, Frédéric, Bossut, Jessie, Fiant, Elodie, Frébourg, Thierry, Sabourin, Jean-Christophe

“…KRAS genotyping is mandatory before anti-epidermal growth factor receptor monoclonal antibody therapy in metastatic colorectal cancer, which is the second…”
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Inactivation of the RRB1-Pescadillo pathway involved in ribosome biogenesis induces chromosomal instability by KILLIAN, Audrey, LE MEUR, Nathalie, SESBOÜE, Richard, BOURGUIGNON, Jeannette, BOUGEARD, Gaëlle, GAUTHEROT, Julien, BASTARD, Christian, FREBOURG, Thierry, FLAMAN, Jean-Michel

“…Since chromosomal instability (CIN) is a hallmark of most cancer cells, it is essential to identify genes whose alteration results into this genetic…”
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Overexpression of B-type cyclins alters chromosomal segregation by SARAFAN-VASSEUR, Nasrin, LAMY, Aude, BOURGUIGNON, Jeannette, LE PESSOT, Florence, HIETER, Philip, SESBOÜE, Richard, BASTARD, Christian, FREBOURG, Thierry, FLAMAN, Jean-Michel

“…To identify genes which overexpression results into chromosomal instability (CIN), we developed a biological approach based on a yeast indicator strain in…”
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A Simple Method for the Routine Detection of Somatic Quantitative Genetic Alterations in Colorectal Cancer by Killian, Audrey, Di Fiore, Frédéric, Le Pessot, Florence, Blanchard, France, Lamy, Aude, Raux, Grégory, Flaman, Jean–Michel, Paillot, Bernard, Michel, Pierre, Sabourin, Jean–Christophe, Tuech, Jean–Jacques, Michot, Francis, Kerckaert, Jean–Pierre, Sesboüé, Richard, Frebourg, Thierry

“…Background & Aims: Several quantitative genetic alterations have been suggested to have in colorectal cancer (CRC) either a prognostic or a therapeutic…”
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Predictive Survival Markers in Patients with Surgically Resected Non-Small Cell Lung Carcinoma by Moldvay, J, Scheid, P, Wild, P, Nabil, K, Siat, J, Borrelly, J, Marie, B, Farré, G, Labib, T, Pottier, G, Sesboüé, R, Bronner, C, Vignaud, J M, Martinet, Y, Martinet, N

“…Among patients with resected non-small cell lung carcinoma, about 50% will present a tumor recurrence. Thus, it would be of major importance to be able to…”
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Photodynamic therapy using methylene blue in lung adenocarcinoma xenograft and hamster cheek pouch induced squamous cell carcinoma by Obstoy, Bérengère, Salaun, Mathieu, Bohn, Pierre, Veresezan, Liana, Sesboué, Richard, Thiberville, Luc

“…Highlights • Methylene blue (MB) is evaluated as a photodynamic agent for cancer treatment of lung adenocarcinoma xenograft and Hamster cheek pouch induced…”
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Drastic Effect of Germline TP53 Missense Mutations in Li-Fraumeni Patients by Zerdoumi, Yasmine, Aury-Landas, Juliette, Bonaïti-Pellié, Catherine, Derambure, Céline, Sesboüé, Richard, Renaux-Petel, Mariette, Frebourg, Thierry, Bougeard, Gaëlle, Flaman, Jean-Michel

“…ABSTRACT In contrast to other tumor suppressor genes, the majority of TP53 alterations are missense mutations. We have previously reported that in the…”
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Copy number variations in DCC/18q and ERBB2/17q are associated with disease‐free survival in microsatellite stable colon cancer by Sefrioui, David, Vermeulin, Thomas, Blanchard, France, Chapusot, Caroline, Beaussire, Ludivine, Armengol‐Debeir, Laura, Sesboué, Richard, Gangloff, Alice, Hebbar, Mohamed, Copin, Marie‐Christine, Houivet, Estelle, Schwarz, Lilian, Clatot, Florian, Tuech, Jean‐Jacques, Bénichou, Jacques, Martin, Laurent, Bouvier, Anne‐Marie, Sabourin, Jean‐Christophe, Sarafan‐Vasseur, Nasrin, Frébourg, Thierry, Lepage, Côme, Michel, Pierre, Di Fiore, Frédéric

“…We conducted a prospective study to assess the prognostic impact of selected copy number variations (CNVs) in Stage II–III microsatellite stable (MSS) colon…”
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Real-time molecular optical micro-imaging of EGFR mutations using a fluorescent erlotinib based tracer by Patout, Maxime, Guisier, Florian, Brune, Xavier, Bohn, Pierre, Romieu, Anthony, Sarafan-Vasseur, Nasrin, Sesboüé, Richard, Renard, Pierre-Yves, Thiberville, Luc, Salaün, Mathieu

“…EGFR mutations are routinely explored in lung adenocarcinoma by sequencing tumoral DNA. The aim of this study was to evaluate a fluorescent-labelled erlotinib…”
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Molecular Predictive Factors for Progression of High-Grade Preinvasive Bronchial Lesions by Salaun, Mathieu, Sesboue, Richard, Moreno-Swirc, Sophie, Metayer, Josette, Bota, Suzanna, Bourguignon, Jeannette, Thiberville, Luc

“…The outcome of precancerous bronchial lesions is not well known, and their management is subject to controversy. Many molecular alterations are present in…”
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Analysis of anti‐neutrophil cytoplasmic antibodies (ANCA): frequency and specificity in a sample of 191 homozygous (PiZZ) alpha1‐antitrypsin‐deficient subjects by Audrain, Marie A. P., Sesboüé, Richard, Baranger, Thierry A. R., Elliott, Jane, Testa, Angelo, Martin, Jean‐Pierre, Lockwood, C. Martin, Esnault, Vincent L. M.

“…Background. ANCA are autoantibodies directed against polymorphonuclear cell antigens, mainly proteinase 3 (PR3) and myeloperoxidase (MPO), which are implicated…”
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Contribution of theBOP1 gene, located on 8q24, to colorectal tumorigenesis by Killian, Audrey, Sarafan-Vasseur, Nasrin, Sesboüé, Richard, Le Pessot, Florence, Blanchard, France, Lamy, Aude, Laurent, Michelle, Flaman, Jean-Michel, Frébourg, Thierry

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Aberrant methylation of the CDKN2a/p16INK4a gene promoter region in preinvasive bronchial lesions: A prospective study in high‐risk patients without invasive cancer by Lamy, Aude, Sesboüé, Richard, Bourguignon, Jeannette, Dautréaux, Brigitte, Métayer, Josette, Frébourg, Thierry, Thiberville, Luc

“…Among the identified factors involved in malignant transformation, abnormal methylation of the CDKN2A/p16INK4a gene promoter has been described as an early…”
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A multiplex technology platform for the rapid analysis of clinically actionable genetic alterations and validation for BRAF p.V600E detection in 1549 cytologic and histologic specimens by Smith, David L, Lamy, Aude, Beaudenon-Huibregtse, Sylvie, Sesboüé, Richard, Laosinchai-Wolf, Walairat, Sabourin, Jean-Christophe, Labourier, Emmanuel

“…Current clinicopathologic assessment of malignant neoplastic diseases entails the analysis of specific genetic alterations that provide diagnostic, prognostic,…”
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Hyaluronectin modulation of lung metastasis in nude mice by Paris, Sébastien, Sesboüé, Richard, Chauzy, Claude, Maingonnat, Catherine, Delpech, Bertrand

“…Hyaluronectin (HN) is a glycoprotein with a high affinity to hyaluronic acid (HA) and known to be a component of the extracellular matrix of tumours. Clinical…”
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Re: Promoter Methylation and Silencing of the Retinoic Acid Receptor-β Gene in Lung Carcinomas by Lamy, Aude, Métayer, Josette, Thiberville, Luc, Frébourg, Thierry, Sesboüé, Richard

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Metastasis models: the green fluorescent revolution? by Paris, Sébastien, Sesboüé, Richard

“…Metastases are the leading cause of treatment failure and death of patients affected by malignant tumors, which makes them a major therapeutic target. During…”
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Clinical value of chip-based digital-PCR platform for the detection of circulating DNA in metastatic colorectal cancer by Sefrioui, David, Sarafan-Vasseur, Nasrin, Beaussire, Ludivine, Baretti, Marina, Gangloff, Alice, Blanchard, France, Clatot, Florian, Sabourin, Jean-Christophe, Sesboüé, Richard, Frebourg, Thierry, Michel, Pierre, Di Fiore, Frédéric

“…Abstract Background The detection of circulating DNA is considered a promising strategy in cancer patients. Digital PCR has emerged as a sensitive method able…”
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