Search Results - "Sesack, Susan R."

Cortico-Basal Ganglia Reward Network: Microcircuitry by Sesack, Susan R, Grace, Anthony A

“…Many of the brain's reward systems converge on the nucleus accumbens, a region richly innervated by excitatory, inhibitory, and modulatory afferents…”
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Bidirectional Modulation of Incubation of Cocaine Craving by Silent Synapse-Based Remodeling of Prefrontal Cortex to Accumbens Projections by Ma, Yao-Ying, Lee, Brian R., Wang, Xiusong, Guo, Changyong, Liu, Lei, Cui, Ranji, Lan, Yan, Balcita-Pedicino, Judith J., Wolf, Marina E., Sesack, Susan R., Shaham, Yavin, Schlüter, Oliver M., Huang, Yanhua H., Dong, Yan

“…Glutamatergic projections from the medial prefrontal cortex (mPFC) to nucleus accumbens (NAc) contribute to cocaine relapse. Here we show that silent…”
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Lateral habenula projections to dopamine and GABA neurons in the rat ventral tegmental area by Omelchenko, Natalia, Bell, Roland, Sesack, Susan R.

“…Ventral tegmental area (VTA) dopamine (DA) neurons and their forebrain projections are critically involved in reward processing and cognitive functions…”
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The inhibitory influence of the lateral habenula on midbrain dopamine cells: Ultrastructural evidence for indirect mediation via the rostromedial mesopontine tegmental nucleus by Balcita-Pedicino, Judith Joyce, Omelchenko, Natalia, Bell, Roland, Sesack, Susan R.

“…The lateral habenula (LHb) provides an important source of negative reinforcement signals to midbrain dopamine (DA) cells in the substantia nigra and ventral…”
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Ultrastructural analysis of local collaterals of rat ventral tegmental area neurons: GABA phenotype and synapses onto dopamine and GABA cells by Omelchenko, Natalia, Sesack, Susan R.

“…Local synapses formed by nondopamine cells within the ventral tegmental area (VTA) are thought to provide an important regulatory influence on the activity…”
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Habenula: Crossroad between the Basal Ganglia and the Limbic System by Hikosaka, Okihide, Sesack, Susan R, Lecourtier, Lucas, Shepard, Paul D

“…There is a growing awareness that emotion, motivation, and reward values are important determinants of our behavior. The habenula is uniquely positioned both…”
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Periaqueductal gray afferents synapse onto dopamine and GABA neurons in the rat ventral tegmental area by Omelchenko, Natalia, Sesack, Susan R.

“…The midbrain central gray (periaqueductal gray; PAG) mediates defensive behaviors and is implicated in the rewarding effects of opiate drugs. Projections from…”
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Control of the nigrostriatal dopamine neuron activity and motor function by the tail of the ventral tegmental area by Bourdy, Romain, Sánchez-Catalán, María-José, Kaufling, Jennifer, Balcita-Pedicino, Judith J, Freund-Mercier, Marie-José, Veinante, Pierre, Sesack, Susan R, Georges, François, Barrot, Michel

“…Midbrain dopamine neurons are implicated in various psychiatric and neurological disorders. The GABAergic tail of the ventral tegmental area (tVTA), also named…”
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Selective elimination of glutamatergic synapses on striatopallidal neurons in Parkinson disease models by Surmeier, D James, Day, Michelle, Wang, Zhongfeng, Ding, Jun, An, Xinhai, Ingham, Cali A, Shering, Andrew F, Wokosin, David, Ilijic, Ema, Sun, Zhuoxin, Sampson, Allan R, Mugnaini, Enrico, Deutch, Ariel Y, Sesack, Susan R, Arbuthnott, Gordon W

“…Parkinson disease is a common neurodegenerative disorder that leads to difficulty in effectively translating thought into action. Although it is known that…”
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Laterodorsal tegmental projections to identified cell populations in the rat ventral tegmental area by Omelchenko, Natalia, Sesack, Susan R.

“…Projections from the laterodorsal tegmentum (LDT) to the ventral tegmental area (VTA) contribute to the activity of dopamine (DA) and GABA cells and, hence, to…”
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Projections from the rat pedunculopontine and laterodorsal tegmental nuclei to the anterior thalamus and ventral tegmental area arise from largely separate populations of neurons by Holmstrand, Ericka C., Sesack, Susan R.

“…Cholinergic and non-cholinergic neurons in the brainstem pedunculopontine (PPT) and laterodorsal tegmental (LDT) nuclei innervate diverse forebrain structures…”
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A Neonatal Ventral Hippocampal Lesion Causes Functional Deficits in Adult Prefrontal Cortical Interneurons by Tseng, Kuei Y, Lewis, Barbara L, Hashimoto, Takanori, Sesack, Susan R, Kloc, Michelle, Lewis, David A, O'Donnell, Patricio

“…Animals with a neonatal ventral hippocampal lesion (NVHL) develop abnormal behaviors during or after adolescence, suggesting that early insults can have…”
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Increased amphetamine-induced hyperactivity and reward in mice overexpressing the dopamine transporter by Salahpour, Ali, Ramsey, Amy J, Medvedev, Ivan O, Kile, Brian, Sotnikova, Tatyana D, Holmstrand, Ericka, Ghisi, Valentina, Nicholls, Peter J, Wong, Ling, Murphy, Karen, Sesack, Susan R, Wightman, R. Mark, Gainetdinov, Raul R, Caron, Marc G

“…The dopamine transporter (DAT) plays a key role in the regulation of dopaminergic signaling wherein it controls both the spatial and temporal actions of…”
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Cholinergic axons in the rat ventral tegmental area synapse preferentially onto mesoaccumbens dopamine neurons by Omelchenko, Natalia, Sesack, Susan R.

“…Cholinergic afferents to the ventral tegmental area (VTA) contribute substantially to the regulation of motivated behaviors and the rewarding properties of…”
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Farewell and announcement by Sesack, Susan R.

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Impact of prenatal nicotine on the structure of midbrain dopamine regions in the rat by Omelchenko, Natalia, Roy, Priya, Balcita-Pedicino, Judith Joyce, Poloyac, Samuel, Sesack, Susan R.

“…In utero exposure of rats to nicotine (NIC) provides a useful animal model for studying the impact of smoking during pregnancy on human offspring. Certain…”
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Automated quantification of dendritic spine density and spine head diameter in medium spiny neurons of the nucleus accumbens by Shen, Haowei, Sesack, Susan R., Toda, Shigenobu, Kalivas, Peter W.

“…Dendritic spines are postsynaptic specializations thought to regulate the strength of synaptic transmission and play a critical role in neuronal plasticity…”
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Chronic Stress Increases the Plasmalemmal Distribution of the Norepinephrine Transporter and the Coexpression of Tyrosine Hydroxylase in Norepinephrine Axons in the Prefrontal Cortex by Miner, LeeAnn H, Jedema, Hank P, Moore, Forrest W, Blakely, Randy D, Grace, Anthony A, Sesack, Susan R

“…Norepinephrine (NE) potently modulates the cognitive and affective functions of the prefrontal cortex (PFC). Deficits in NE transmission are implicated in…”
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Dopamine Axon Varicosities in the Prelimbic Division of the Rat Prefrontal Cortex Exhibit Sparse Immunoreactivity for the Dopamine Transporter by Sesack, Susan R, Hawrylak, Valerie A, Matus, Claudia, Guido, Margaret A, Levey, Allan I

“…The dopamine transporter (DAT) critically regulates the duration of the cellular actions of dopamine and the extent to which dopamine diffuses in the…”
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Mediodorsal thalamic afferents to layer III of the rat prefrontal cortex: Synaptic relationships to subclasses of interneurons by Rotaru, Diana C., Barrionuevo, German, Sesack, Susan R.

“…The mediodorsal nucleus of the thalamus (MD) represents the main subcortical structure that projects to the prefrontal cortex (PFC) and it regulates key…”
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