Search Results - "Seryakov, Aleksander"
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Clinically relevant fusion oncogenes: detection and practical implications
Published in Therapeutic Advances in Medical Oncology (01-01-2022)“…Mechanistically, chimeric genes result from DNA rearrangements and include parts of preexisting normal genes combined at the genomic junction site. Some…”
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Book Review Journal Article -
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Pan-cancer antagonistic inhibition pattern of ATM-driven G2/M checkpoint pathway vs other DNA repair pathways
Published in DNA repair (01-03-2023)“…DNA repair mechanisms keep genome integrity and limit tumor-associated alterations and heterogeneity, but on the other hand they promote tumor survival after…”
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Journal Article -
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Large-scale assessment of pros and cons of autopsy-derived or tumor-matched tissues as the norms for gene expression analysis in cancers
Published in Computational and structural biotechnology journal (01-01-2023)“…Normal tissues are essential for studying disease-specific differential gene expression. However, healthy human controls are typically available only in…”
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Bioinformatic and clinical experimental assay uncovers resistance and susceptibility mechanisms of human glioblastomas to temozolomide and identifies new combined and individual survival biomarkers outperforming MGMT promoter methylation
Published in Therapeutic advances in medical oncology (01-01-2024)“…Background: Glioblastoma (GBM) is the most aggressive and lethal central nervous system (CNS) tumor. The treatment strategy is mainly surgery and/or radiation…”
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Journal Article -
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Bioinformatic and clinical experimental assay uncovers resistance and susceptibility mechanisms of human glioblastomas to temozolomide and identifies new combined and individual survival biomarkers outperforming promoter methylation
Published in Therapeutic advances in medical oncology (01-11-2024)“…Background: Glioblastoma (GBM) is the most aggressive and lethal central nervous system (CNS) tumor. The treatment strategy is mainly surgery and/or radiation…”
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Journal Article