Search Results - "Serve, Kinta"

Plasminogen Binding and Activation at the Mesothelial Cell Surface Promotes Invasion through a Collagen Matrix by Ditzig, Zachary, Wilson, Caleb M, Salas, Jesse, Serve, Kinta M

“…Plasminogen (Plg) activation to the serine protease plasmin (Pla) plays a key role in regulating wound healing and fibrotic responses, particularly when bound…”
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Late Inflammation Induced by Asbestiform Fibers in Mice Is Ameliorated by a Small Molecule Synthetic Lignan by Badger, Reagan, Park, Kyewon, Pietrofesa, Ralph A, Christofidou-Solomidou, Melpo, Serve, Kinta M

“…Exposure to Libby amphibole (LA) asbestos-like fibers is associated with increased risk of asbestosis, mesothelioma, pulmonary disease, and systemic autoimmune…”
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Synthetic secoisolariciresinol diglucoside (LGM2605) inhibits Libby amphibole fiber-induced acute inflammation in mice by Christofidou-Solomidou, Melpo, Pietrofesa, Ralph A., Park, Kyewon, Albelda, Steven M., Serve, Kinta M., Keil, Deborah E., Pfau, Jean C.

“…Exposure to the Libby amphibole (LA) asbestos-like fibers found in Libby, Montana, is associated with inflammatory responses in mice and humans, and an…”
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Short‐term exposure to synthetic flaxseed lignan LGM2605 alters gut microbiota in mice by Badger, Reagan, Aho, Ken, Serve, Kinta

“…LGM2605 is a synthetic version of the naturally occurring flaxseed lignan secoisolariciresinol diglucoside (SDG), with known anti‐inflammatory and antioxidant…”
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Analysis of autoantibody profiles in two asbestiform fiber exposure cohorts by Pfau, Jean C., Barbour, Christopher, Black, Brad, Serve, Kinta M., Fritzler, Marvin J.

“…An increased risk for Systemic Autoimmune Diseases (SAID) was reported in the population of Libby, Montana, where extensive exposure to asbestiform amphiboles…”
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Asbestos-associated mesothelial cell autoantibodies promote collagen deposition in vitro by Serve, Kinta M., Black, Brad, Szeinuk, Jaime, Pfau, Jean C.

“…Abstract Fibrosis, characterized by excessive collagen protein deposition, is a progressive disease that can fatally inhibit organ function. Prolonged exposure…”
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Autoimmunity and Asbestos Exposure by Pfau, Jean C., Serve, Kinta M., Noonan, Curtis W.

“…Despite a body of evidence supporting an association between asbestos exposure and autoantibodies indicative of systemic autoimmunity, such as antinuclear…”
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Mesothelial cell and anti-nuclear autoantibodies associated with pleural abnormalities in an asbestos exposed population of Libby MT by Marchand, Lucas S., St-Hilaire, Sophie, Putnam, Elizabeth A., Serve, Kinta M., Pfau, Jean C.

“…► This study sought to determine whether autoantibodies from asbestos-exposed subjects from Libby MT were associated with pleural lesions. ► Only…”
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Enzymes to die for: exploiting nucleotide metabolizing enzymes for cancer gene therapy by Ardiani, Andressa, Johnson, Adam J, Ruan, Hongmei, Sanchez-Bonilla, Marilyn, Serve, Kinta, Black, Margaret E

“…Suicide gene therapy is an attractive strategy to selectively destroy cancer cells while minimizing unnecessary toxicity to normal cells. Since this idea was…”
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Validation of an isocratic HPLC method to detect 2-fluoro-β-alanine for the analysis of dihydropyrimidine dehydrogenase activity by Serve, Kinta M., Darnell, Jennifer L., Takemoto, Jody K., Davies, Neal M., Black, Margaret E.

“…The efficacy of the chemotherapeutic drug 5′-fluorouracil is reduced by catabolism to 2′-fluoro-β-alanine (FBAL), a three-step reaction in which…”
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Development and validation of a rapid and sensitive HPLC method for the quantification of 5-fluorocytosine and its metabolites by Serve, Kinta M., Yáñez, Jaime A., Remsberg, Connie M., Davies, Neal M., Black, Margaret E.

“…To study the intracellular metabolism of the prodrug 5‐fluorocytosine (5FC), we developed a novel reverse‐phase high‐performance liquid chromatography method…”
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Libby amphibole-induced mesothelial cell autoantibodies promote collagen deposition in mice by Gilmer, John, Serve, Kinta, Davis, Chad, Anthony, Marti, Hanson, Robert, Harding, Tanner, Pfau, Jean C

“…Libby amphibole (LA) causes a unique progressive lamellar pleural fibrosis (LPF) that is associated with pulmonary function decline. Pleural fibrosis among the…”
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Bacterial Cytosine Deaminase Mutants Created by Molecular Engineering Show Improved 5-Fluorocytosine-Mediated Cell Killing In vitro and In vivo by FUCHITA, Michi, ARDIANI, Andressa, LEI ZHAO, SERVE, Kinta, STODDARD, Barry L, BLACK, Margaret E

“…Cytosine deaminase is used in combination with 5-fluorocytosine as an enzyme-prodrug combination for targeted genetic cancer treatment. This approach is…”
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Bacterial Cytosine Deaminase Mutants Created by Molecular Engineering Demonstrate Improved 5FC-Mediated Cell Killing In Vitro and In Vivo by Fuchita, Michi, Ardiani, Andressa, Zhao, Lei, Serve, Kinta, Stoddard, Barry L., Black, Margaret E.

“…Cytosine deaminase is used in combination with 5-fluorocytosine as an enzyme-prodrug combination for targeted genetic cancer treatment. This approach is…”
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The Tale of Two Degrees: The Need and Power of the Doctor of Arts by Serve, Kinta, Clements, Nathan, Heinrich, Kaleb K., Smith, Rosemary J.

“…Ph.D. programs train students to perform quality research but not necessarily to deliver quality undergraduate instruction. For students who want to develop…”
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Mesothelial Cell Autoantibodies Induce Collagen Deposition in vitro & Using a Case Study to Introduce Undergraduates to Bioinformatics by Serve, Kinta M

“…Part I. Pleural fibrosis, a non-malignant, asbestos-related respiratory disease characterized by excessive collagen deposition, is progressive, debilitating,…”
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Mesothelial Cell Autoantibodies Induce Collagen Deposition in vitro & Using a Case Study to Introduce Undergraduates to Bioinformatics by Serve, Kinta M

“…Part I. Pleural fibrosis, a non-malignant, asbestos-related respiratory disease characterized by excessive collagen deposition, is progressive, debilitating,…”
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