Search Results - "Servant, Marc"

TRK-Fused Gene (TFG), a protein involved in protein secretion pathways, is an essential component of the antiviral innate immune response by Khan, Kashif Aziz, Marineau, Alexandre, Doyon, Priscilla, Acevedo, Mariana, Durette, Étienne, Gingras, Anne-Claude, Servant, Marc J

“…Antiviral innate immune response to RNA virus infection is supported by Pattern-Recognition Receptors (PRR) including RIG-I-Like Receptors (RLR), which lead to…”
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Oxidative stress-induced senescence mediates inflammatory and fibrotic phenotypes in fibroblasts from systemic sclerosis patients by Kizilay Mancini, Ozge, Acevedo, Mariana, Fazez, Nesrine, Cuillerier, Alexanne, Fernandez Ruiz, Ana, Huynh, David N, Burelle, Yan, Ferbeyre, Gerardo, Baron, Murray, Servant, Marc J

“…Abstract Objective SSc is an autoimmune connective tissue disorder characterized by inflammation and fibrosis. Although constitutive activation of fibroblasts…”
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Direct and Indirect Induction by 1,25-Dihydroxyvitamin D3 of the NOD2/CARD15-Defensin β2 Innate Immune Pathway Defective in Crohn Disease by Wang, Tian-Tian, Dabbas, Basel, Laperriere, David, Bitton, Ari J., Soualhine, Hafid, Tavera-Mendoza, Luz E., Dionne, Serge, Servant, Marc J., Bitton, Alain, Seidman, Ernest G., Mader, Sylvie, Behr, Marcel A., White, John H.

“…Vitamin D signaling through its nuclear vitamin D receptor has emerged as a key regulator of innate immunity in humans. Here we show that hormonal vitamin D,…”
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Loss of interleukin-17 receptor D promotes chronic inflammation-associated tumorigenesis by Girondel, Charlotte, Lévesque, Kim, Langlois, Marie-Josée, Pasquin, Sarah, Saba-El-Leil, Marc K., Rivard, Nathalie, Friesel, Robert, Servant, Marc J., Gauchat, Jean-François, Lesage, Sylvie, Meloche, Sylvain

“…Interleukin-17 receptor D (IL-17RD), also known as similar expression to Fgf genes (SEF), is proposed to act as a signaling hub that negatively regulates…”
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Roles of GSK-3 and β-Catenin in Antiviral Innate Immune Sensing of Nucleic Acids by Marineau, Alexandre, Khan, Kashif Aziz, Servant, Marc J

“…The rapid activation of the type I interferon (IFN) antiviral innate immune response relies on ubiquitously expressed RNA and DNA sensors. Once engaged, these…”
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Ex vivo Ikkβ ablation rescues the immunopotency of mesenchymal stromal cells from diabetics with advanced atherosclerosis by Kizilay Mancini, Ozge, Huynh, David N, Menard, Liliane, Shum-Tim, Dominique, Ong, Huy, Marleau, Sylvie, Colmegna, Ines, Servant, Marc J

“…Abstract Aims Diabetes is a conventional risk factor for atherosclerotic cardiovascular disease and myocardial infarction (MI) is the most common cause of…”
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Deep Tissue Penetration of Bottle-Brush Polymers via Cell Capture Evasion and Fast Diffusion by Rabanel, Jean-Michel, Mirbagheri, Marziye, Olszewski, Mateusz, Xie, Guojun, Le Goas, Marine, Latreille, Pierre-Luc, Counil, Hermine, Hervé, Vincent, Silva, Rummenigge Oliveira, Zaouter, Charlotte, Adibnia, Vahid, Acevedo, Mariana, Servant, Marc J., Martinez, Vincent A., Patten, Shunmoogum A., Matyjaszewski, Krzysztof, Ramassamy, Charles, Banquy, Xavier

“…Drug nanocarriers (NCs) capable of crossing the vascular endothelium and deeply penetrating into dense tissues of the CNS could potentially transform the…”
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The IKK-related kinases： from innate immunity to oncogenesis by Clément, Jean-François, Meloche, Sylvain, Servant, Marc J

“…Over the past four years, the field of the innate immune response has been highly influenced by the discovery of the IKB kinase （IKK）-related kinases, TANK…”
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Mitochondrial Oxidative Stress Reduces the Immunopotency of Mesenchymal Stromal Cells in Adults With Coronary Artery Disease by Kizilay Mancini, Ozge, Lora, Maximilien, Cuillerier, Alexanne, Shum-Tim, Dominique, Hamdy, Reggie, Burelle, Yan, Servant, Marc J, Stochaj, Ursula, Colmegna, Inés

“…RATIONALE:Mesenchymal stromal cells (MSCs) are promising therapeutic strategies for coronary artery disease; however, donor-related variability in cell quality…”
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Proteomic profiling of the TRAF3 interactome network reveals a new role for the ER-to-Golgi transport compartments in innate immunity by van Zuylen, Wendy J, Doyon, Priscilla, Clément, Jean-François, Khan, Kashif Aziz, D'Ambrosio, Lisa M, Dô, Florence, St-Amant-Verret, Myriam, Wissanji, Tasheen, Emery, Gregory, Gingras, Anne-Claude, Meloche, Sylvain, Servant, Marc J

“…Tumor Necrosis Factor receptor-associated factor-3 (TRAF3) is a central mediator important for inducing type I interferon (IFN) production in response to…”
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Tumor Necrosis Factor Receptor-associated Factor-6 and Ribosomal S6 Kinase Intracellular Pathways Link the Angiotensin II AT1 Receptor to the Phosphorylation and Activation of the IκB Kinase Complex in Vascular Smooth Muscle Cells by Doyon, Priscilla, Servant, Marc J.

“…Activation of NF-κB transcription factors by locally produced angiotensin II (Ang II) is proposed to be involved in chronic inflammatory reactions leading to…”
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Hereditary Inclusion Body Myopathy-Linked p97/VCP Mutations in the NH2 Domain and the D1 Ring Modulate p97/VCP ATPase Activity and D2 Ring Conformation by Halawani, Dalia, LeBlanc, Andréa C., Rouiller, Isabelle, Michnick, Stephen W., Servant, Marc J., Latterich, Martin

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Fine-Tuning of the RIG-I-Like Receptor/Interferon Regulatory Factor 3-Dependent Antiviral Innate Immune Response by the Glycogen Synthase Kinase 3/β-Catenin Pathway by Khan, Kashif Aziz, Dô, Florence, Marineau, Alexandre, Doyon, Priscilla, Clément, Jean-François, Woodgett, James R., Doble, Bradley W., Servant, Marc J.

“…Induction of an antiviral innate immune response relies on pattern recognition receptors, including retinoic acid-inducible gene 1-like receptors (RLR), to…”
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Transcriptional Profiling of Interferon Regulatory Factor 3 Target Genes: Direct Involvement in the Regulation of Interferon-Stimulated Genes by Grandvaux, Nathalie, Servant, Marc J, tenOever, Benjamin, Sen, Ganes C, Balachandran, Siddarth, Barber, Glen N, Lin, Rongtuan, Hiscott, John

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Systemic sclerosis immunoglobulin induces growth and a pro-fibrotic state in vascular smooth muscle cells through the epidermal growth factor receptor by Arts, Monique R, Baron, Murray, Chokr, Nidaa, Fritzler, Marvin J, Servant, Marc J

“…It has been suggested that autoantibodies in systemic sclerosis (SSc) may induce the differentiation of cultured fibroblasts into myofibroblasts through…”
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Genome-wide RNAi screen reveals a new role of a WNT/CTNNB1 signaling pathway as negative regulator of virus-induced innate immune responses by Baril, Martin, Es-Saad, Salwa, Chatel-Chaix, Laurent, Fink, Karin, Pham, Tram, Raymond, Valérie-Ann, Audette, Karine, Guenier, Anne-Sophie, Duchaine, Jean, Servant, Marc, Bilodeau, Marc, Cohen, Eric, Grandvaux, Nathalie, Lamarre, Daniel

“…To identify new regulators of antiviral innate immunity, we completed the first genome-wide gene silencing screen assessing the transcriptional response at the…”
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Role of IκB Kinase-β in the Growth-Promoting Effects of Angiotensin II In Vitro and In Vivo by Doyon, Priscilla, van Zuylen, Wendy J, Servant, Marc J

“…OBJECTIVE—Angiotensin II (Ang II) is implicated in processes underlying the development of arterial wall remodeling events, including cellular hypertrophy and…”
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TNF‐α expression in neutrophils and its regulation by glycogen synthase kinase‐3: A potentiating role for lithium by Giambelluca, Miriam S., Bertheau‐Mailhot, Geneviève, Laflamme, Cynthia, Rollet‐Labelle, Emmanuelle, Servant, Marc J., Pouliot, Marc

“…Glycogen synthase kinase 3 (GSK‐3) is associated with several cellular systems, including immune response. Lithium, a widely used pharmacological treatment for…”
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Roles of ubiquitination in pattern-recognition receptors and type I interferon receptor signaling by Bibeau-Poirier, Annie, Servant, Marc J.

“…Post-translational protein modifications are involved in all functions of living cells. This includes the ability of cells to recognize pathogens and regulate…”
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Phosphorylation of IRF-3 on Ser 339 Generates a Hyperactive Form of IRF-3 through Regulation of Dimerization and CBP Association by CLEMENT, Jean-Francois, BIBEAU-POIRIER, Annie, GRAVEL, Simon-Pierre, GRANDVAUX, Nathalie, BONNEIL, Eric, THIBAULT, Pierre, MELOCHE, Sylvain, SERVANT, Marc J

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