Search Results - "Serup, P."

A step closer to making beta cells by Serup, P.

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Conditional and Specific NF-κB Blockade Protects Pancreatic Beta Cells from Diabetogenic Agents by Eldor, R., Yeffet, A., Baum, K., Doviner, V., Amar, D., Ben-Neriah, Y., Christofori, G., Peled, A., Carell, J. C., Boitard, C., Klein, T., Serup, P., Eizirik, D. L., Melloul, D.

“…Type 1 diabetes is characterized by the infiltration of inflammatory cells into pancreatic islets of Langerhans, followed by the selective and progressive…”
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Lower Blood Glucose, Hyperglucagonemia, and Pancreatic α Cell Hyperplasia in Glucagon Receptor Knockout Mice by Gelling, R. W., Du, X. Q., Dichmann, D. S., Rømer, J., Huang, H., Cui, L., Obici, S., Tang, B., Holst, J. J., Fledelius, C., Johansen, P. B., Rossetti, L., Jelicks, L. A., Serup, P., Nishimura, E., Charron, M. J.

“…Glucagon, the counter-regulatory hormone to insulin, is secreted from pancreatic α cells in response to low blood glucose. To examine the role of glucagon in…”
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Embryonic stem cell-based diabetes therapy--a long road to travel by Serup, P

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Homeobox gene Nkx2.2 and specification of neuronal identity by graded Sonic hedgehog signalling by Rubenstein, J. L. R, Briscoe, J, Sussel, L, Serup, P, Hartigan-O'Connor, D, Jessell, T. M, Ericson, J

“…During vertebrate development, the specification of distinct cell types is thought to be controlled by inductive signals acting at different concentration…”
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Independent development of pancreatic alpha- and beta-cells from neurogenin3-expressing precursors: a role for the notch pathway in repression of premature differentiation by JENSEN, J, HELLER, R. S, FUNDER-NIELSEN, T, PEDERSEN, E. E, LINDSELL, C, WEINMASTER, G, MADSEN, O. D, SERUP, P

“…Independent development of pancreatic alpha- and beta-cells from neurogenin3-expressing precursors: a role for the notch pathway in repression of premature…”
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The c-Jun amino-terminal kinase pathway is preferentially activated by interleukin-1 and controls apoptosis in differentiating pancreatic beta-cells by AMMENDRUP, A, MAILLARD, A, NIELSEN, K, ANDERSEN, N. A, SERUP, P, MADSEN, O. D, MANDRUP-POULSEN, T, BONNY, C

“…The c-Jun amino-terminal kinase pathway is preferentially activated by interleukin-1 and controls apoptosis in differentiating pancreatic beta-cells. A…”
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Science, Medicine, And The Future: Islet And Stem Cell Transplantation For Treating Diabetes by Serup, Palle, Madsen, Ole D., Mandrup-Poulsen, Thomas

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Immunohistochemistry of Pancreatic Development in Cattle and Pig by Carlsson, G.L, Scott Heller, R, Serup, P, Hyttel, P

“…With 8 figures and 2 tables The aim of this study was to characterize bovine and porcine pancreatic development by immunohistochemistry. In the pig, staining…”
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Transcriptional Regulation of the Human Insulin Gene is Dependent on the Homeodomain Protein STF1/IPF1 Acting Through the CT Boxes by Petersen, Helle V., Serup, Palle, Leonard, James, Michelsen, Birgitte K., Madsen, Ole D.

“…Insulin gene transcription is a unique feature of the pancreatic β cells and is increased in response to glucose. The recent cloning of insulin promoter factor…”
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Novel monoclonal antibodies against Pdx1 reveal feedback regulation of Pdx1 protein levels by Galbo, T, Pedersen, I L, Fløyel, T, Bang-Berthelsen, C H, Serup, P, Madsen, O D, Hald, J

“…The aim of this study was to characterize two monoclonal antibodies (F6A11 and F109-D12) generated against Pdx1 (pancreatic and duodenal homeobox-1), a…”
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Panning for pancreatic stem cells by Serup, Palle

“…Thanks to their much-lauded potential in treating a variety of debilitating diseases, and their recent isolation, human embryonic stem (ES) cells have been the…”
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Induction of Insulin and Islet Amyloid Polypeptide Production in Pancreatic Islet Glucagonoma Cells by Insulin Promoter Factor 1 by Serup, Palle, Jensen, Jan, Andersen, Frank G., Jørgensen, Mette C., Blume, Niels, Holst, Jens J., Madsen, Ole D.

“…Insulin promoter factor 1 (IPF1), a member of the homeodomain protein family, serves an early role in pancreas formation, as evidenced by the lack of pancreas…”
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Beta-cell maturation leads to in vitro sensitivity to cytotoxins by NIELSEN, K, KARLSEN, A. E, DECKERT, M, MADSEN, O. D, SERUP, P, MANDRUP-POULSEN, T, NERUP, J

“…Beta-cell maturation leads to in vitro sensitivity to cytotoxins. K Nielsen , A E Karlsen , M Deckert , O D Madsen , P Serup , T Mandrup-Poulsen and J Nerup…”
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The homeodomain protein IPF-1/STF-1 is expressed in a subset of islet cells and promotes rat insulin 1 gene expression dependent on an intact E1 helix-loop-helix factor binding site by Serup, P, Petersen, H V, Pedersen, E E, Edlund, H, Leonard, J, Petersen, J S, Larsson, L I, Madsen, O D

“…The mouse homeodomain protein insulin promoter factor-1 (IPF-1) and the rat homologue somatostatin transactivating factor-1 (STF-1) are involved in early…”
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Anteroposterior polarity and elongation in the absence of extraembryonic tissues and spatially localised signalling in Gastruloids , mammalian embryonic organoids by Turner, D. A., Girgin, M., Alonso-Crisostomo, L., Trivedi, V., Baillie-Johnson, P., Glodowski, C. R., Hayward, P. C., Collignon, J., Gustavsen, C., Serup, P., Steventon, B., Lutolf, M., Martinez, Arias A.

“…The establishment of the anteroposterior (AP) axis is a critical step during animal embryo development. In mammals, genetic studies have shown that this…”
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The LIM family transcription factor Isl-1 requires cAMP response element binding protein to promote somatostatin expression in pancreatic islet cells by LEONARD, J, SERUP, P, GONZALEZ, G, EDLUND, T, MONTMINY, M

“…Many eukaryotic genes are regulated by cAMP through a conserved cAMP response element (CRE). Here we show that, in the pancreatic islet cell line Tu6, a…”
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Transcription factors contributing to the pancreatic beta-cell phenotype by Madsen, O D, Jensen, J, Petersen, H V, Pedersen, E E, Oster, A, Andersen, F G, Jørgensen, M C, Jensen, P B, Larsson, L I, Serup, P

“…Insulin promoter factor-1 (IPF1) (renamed to pancreatic-duodenal homeobox factor-1, PDX1) was originally cloned and characterized as an islet beta-cell…”
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Inhibition of Cdk5 Promotes β-Cell Differentiation From Ductal Progenitors by Liu, Ka-Cheuk, Leuckx, Gunter, Sakano, Daisuke, Seymour, Philip A, Mattsson, Charlotte L, Rautio, Linn, Staels, Willem, Verdonck, Yannick, Serup, Palle, Kume, Shoen, Heimberg, Harry, Andersson, Olov

“…Inhibition of notch signaling is known to induce differentiation of endocrine cells in zebrafish and mouse. After performing an unbiased in vivo screen of…”
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IMPAN Cells: A Pancreatic Model for Differentiation into Endocrine Cells by Klein, Tino, Frandsen, Ulrik, Heller, R.Scott, Serup, Palle

“…It is currently believed that pancreatic progenitor or stem cells exist in the ductal cell population and that these cells have the ability to be grown and…”
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