Search Results - "Sershen, H"

Specific calpain inhibition by calpastatin prevents tauopathy and neurodegeneration and restores normal lifespan in tau P301L mice by Rao, Mala V, McBrayer, Mary Kate, Campbell, Jabbar, Kumar, Asok, Hashim, Audrey, Sershen, Henry, Stavrides, Philip H, Ohno, Masuo, Hutton, Michael, Nixon, Ralph A

“…Tau pathogenicity in Alzheimer's disease and other tauopathies is thought to involve the generation of hyperphosphorylated, truncated, and oligomeric tau…”
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Nicotine: Alcohol Reward Interactions by Lajtha, A., Sershen, H.

“…It is well established that the continued intake of drugs of abuse is reinforcing—that is repeated consumption increases preference. This has been shown in…”
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Neurofilament subunits are integral components of synapses and modulate neurotransmission and behavior in vivo by Yuan, A, Sershen, H, Veeranna, Basavarajappa, B S, Kumar, A, Hashim, A, Berg, M, Lee, J-H, Sato, Y, Rao, M V, Mohan, P S, Dyakin, V, Julien, J-P, Lee, V M-Y, Nixon, R A

“…Synaptic roles for neurofilament (NF) proteins have rarely been considered. Here, we establish all four NF subunits as integral resident proteins of synapses…”
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An upregulation of DNA-methyltransferase 1 and 3a expressed in telencephalic GABAergic neurons of schizophrenia patients is also detected in peripheral blood lymphocytes by Zhubi, A, Veldic, M, Puri, N.V, Kadriu, B, Caruncho, H, Loza, I, Sershen, H, Lajtha, A, Smith, R.C, Guidotti, A, Davis, J.M, Costa, E

“…Abstract Several lines of schizophrenia (SZ) research suggest that a functional downregulation of the prefrontal cortex GABAergic neuronal system is mediated…”
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DNA-methylation gene network dysregulation in peripheral blood lymphocytes of schizophrenia patients by Auta, J, Smith, R.C, Dong, E, Tueting, P, Sershen, H, Boules, S, Lajtha, A, Davis, J, Guidotti, A

“…Abstract The epigenetic dysregulation of the brain genome associated with the clinical manifestations of schizophrenia (SZ) includes altered DNA promoter…”
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Heterogeneity of Reward Mechanisms by Lajtha, A., Sershen, H.

“…The finding that many drugs that have abuse potential and other natural stimuli such as food or sexual activity cause similar chemical changes in the brain, an…”
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Inhibition of System A-mediated glycine transport in cortical synaptosomes by therapeutic concentrations of clozapine: implications for mechanisms of action by JAVITT, D. C, DUNCAN, L, BALLA, A, SERSHEN, H

“…Clozapine is an atypical antipsychotic with particular efficacy in schizophrenia, possibly related to potentiation of brain N-methyl-D-aspartate receptor…”
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Differences between nicotine and cocaine-induced conditioned place preferences by Sershen, H, Hashim, A, Lajtha, A

“…Abstract In previous studies, we found differences between nicotine and cocaine-induced changes in the levels of neurotransmitters in various brain areas,…”
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Nicotine-induced monoamine neurotransmitter changes in the brain of young rats by Shearman, E, Fallon, S, Sershen, H, Lajtha, A

“…Abstract A number of studies in various species including man indicated a greater risk of drug preference and addictive behavior in young as compared to…”
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Functions of neurofilaments in synapses by Yuan, A, Sershen, H, Veeranna, Basavarajappa, B S, Kumar, A, Hashim, A, Berg, M, Lee, J-H, Sato, Y, Rao, M V, Mohan, P S, Dyakin, V, Julien, J-P, Lee, V M-Y, Nixon, R A

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Effect of nicotine and cocaine on neurofilaments and receptors in whole brain tissue and synaptoneurosome preparations by Kovacs, K, Lajtha, A, Sershen, H

“…Abstract The present study examined the effect of repeated nicotine and cocaine administration on the expression of neurofilament proteins (NF-L, -M, and -H),…”
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Changes in cerebral neurotransmitters and metabolites induced by acute donepezil and memantine administrations: A microdialysis study by Shearman, E., Rossi, S., Szasz, B., Juranyi, Z., Fallon, S., Pomara, N., Sershen, H., Lajtha, A.

“…Cholinesterase inhibitors including donepezil, rivastigmine, and galantamine and the N-methyl- d-aspartate (NMDA) antagonist, memantine are the medications…”
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Nicotine-induced changes in neurotransmitter levels in brain areas associated with cognitive function by Singer, S, Rossi, S, Verzosa, S, Hashim, A, Lonow, R, Cooper, T, Sershen, H, Lajtha, A

“…Nicotine, one of the most widespread drugs of abuse, has long been shown to impact areas of the brain involved in addiction and reward. Recent research,…”
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Locally administered low nicotine-induced neurotransmitter changes in areas of cognitive function by Shearman, E, Rossi, S, Sershen, H, Hashim, A, Lajtha, A

“…The present study examined the effect of a low-dose of nicotine; below that one expects to be achieved from a single cigarette, on brain regional heterogeneity…”
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The effects of glutamate and GABA receptor antagonists on nicotine-induced neurotransmitter changes in cognitive areas by Fallon, S, Shearman, E, Sershen, H, Lajtha, A

“…In the present study, we tested the effects of glutamate and GABA receptor antagonists on nicotine-induced neurotransmitter changes in the hippocampal (dorsal…”
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P.3.d.068 Varenicline effects on smoking, cognition and psychiatric symptoms in schizophrenia by Amiaz, R, Smith, R, Si, T.M, Maayan, L, Jin, H.U.A, Boules, S, Sershen, H, Li, C, Ren, J, Yanhong, R, Lajtha, A, Guidotti, A, Weiser, M, Davis, J

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The effects of acetaldehyde on nicotine-induced transmitter levels in young and adult brain areas by Sershen, H, Shearman, E, Fallon, S, Chakraborty, G, Smiley, J, Lajtha, A

“…Abstract The aim of the present study was to examine the effect of acetaldehyde administration on neurotransmitters in the presence of nicotine in brain areas…”
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The effects of cholinergic and dopaminergic antagonists on nicotine-induced cerebral neurotransmitter changes by Rossi, S, Singer, S, Shearman, E, Sershen, H, Lajtha, A

“…In a continuing study of nicotine-induced mechanisms in brain areas associated with cognitive processes, the effects of cholinergic and dopaminergic…”
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Characterization of nicotinic receptors involved in the release of noradrenaline from the hippocampus by Sershen, H, Balla, A, Lajtha, A, Vizi, E.S

“…The pharmacological features of putative nicotinic acetylcholine receptor sites involved in the release of [ 3H]noradrenaline were assessed in rat hippocampus…”
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Receptors in the ventral tegmental area mediating nicotine-induced dopamine release in the nucleus accumbens by SZIRAKI, Istvan, SERSHEN, Henry, HASHIM, Audrey, LAJTHA, Abel

“…Nicotine or cocaine, when administered intravenously, induces an increase of extracellular dopamine in the nucleus accumbens. The nicotine-mediated increase…”
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