Search Results - "Serre, Raphael"
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Mathematical modeling of disease dynamics in SDHB- and SDHD-related paraganglioma: Further step in understanding hereditary tumor differences and future therapeutic strategies
Published in PloS one (14-08-2018)“…Succinate dehydrogenase subunit B and D (SDHB and SDHD) mutations represent the most frequent cause of hereditary pheochromocytoma and paraganglioma (PPGL)…”
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Mathematical modeling of peripheral blood neutrophil kinetics to predict CLAD after lung transplantation
Published in Transplant immunology (01-10-2020)“…The presence of neutrophils in the lung was identified as a factor associated with CLAD but requires invasive samples. The aim of this study was to assess the…”
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Mathematical modeling for Phase I cancer trials: A study of metronomic vinorelbine for advanced non-small cell lung cancer (NSCLC) and mesothelioma patients
Published in Oncotarget (18-07-2017)“…Using mathematical modelling allows to select a treatment's regimen across infinite possibilities. Here, we report the phase I assessment of a new schedule for…”
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Modeling therapeutic response to radioiodine in metastatic thyroid cancer: a proof-of-concept study for individualized medicine
Published in Oncotarget (13-06-2017)“…Radioiodine therapy (RAI) has traditionally been used as treatment for metastatic thyroid cancer, based on its ability to concentrate iodine. Propositions to…”
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Phase II study of concomitant radiotherapy with atezolizumab in oligometastatic soft tissue sarcomas: STEREOSARC trial protocol
Published in BMJ open (23-09-2020)“…IntroductionUp to 50% of soft tissue sarcoma (STS) patients develop metastases in the course of their disease. Cytotoxic therapy is a standard treatment in…”
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Abstract 4542: A mathematical model for immuno-chemotherapy
Published in Cancer research (Chicago, Ill.) (01-07-2017)“…Abstract Chemotherapy and immunotherapy have sometimes been considered two mutually exclusive approaches. On the one hand, chemotherapy has long been…”
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Mathematical Modeling of Cancer Immunotherapy and Its Synergy with Radiotherapy
Published in Cancer research (Chicago, Ill.) (01-09-2016)“…Combining radiotherapy with immune checkpoint blockade may offer considerable therapeutic impact if the immunosuppressive nature of the tumor microenvironment…”
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Abstract 2704: Radiotherapy and immunotherapy in cancer: A mathematical model
Published in Cancer research (Chicago, Ill.) (15-07-2016)“…Abstract The rise of immunotherapy is a major breakthrough in oncology. Recently, the combination of radiotherapy with the blockade of immune checkpoint…”
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Optimization of trabectedin temporal protocol using mathematical PK/PD modeling
Published in Journal of clinical oncology (20-05-2018)“…Abstract only…”
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Model-driven metronomic vinorelbine in heavily pre-treated metastatic NSCLC and PM patients: Results of a phase I/II study
Published in Journal of clinical oncology (20-05-2019)“…Abstract only e20505 Background: A phase I/II trial (NCT02555007) of oral metronomic Vinorelbine derived from a mathematical model was performed in heavily…”
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Immunologically effective dose: a practical model for immuno-radiotherapy
Published in Oncotarget (07-08-2018)“…Concomitant radiotherapy with immune checkpoint blockade could be synergistic. Out-of-field effects could improve survival by slowing or blocking metastatic…”
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Abstract 4062: A computational driven protocol of metronomic oral vinorelbine in metastatic non small cell lung cancer
Published in Cancer research (Chicago, Ill.) (01-07-2017)“…Abstract Over the last decade, metronomic chemotherapy (MC) has emerged as an alternative way to administrate chemotherapy. MC can be defined as regular…”
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