Search Results - "Serratosa, J."

Randomized phase III study 306: Adjunctive perampanel for refractory partial-onset seizures by KRAUSS, G. L, SERRATOSA, J. M, LAURENZA, A, VILLANUEVA, V, ENDZINIENE, M, HONG, Z, FRENCH, J, YANG, H, SQUILLACOTE, D, EDWARDS, H. B, ZHU, J

“…To evaluate the efficacy and safety of perampanel 2, 4, and 8 mg/day added to 1-3 concomitant antiepileptic drugs (AEDs) in patients with uncontrolled…”
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Safety, efficacy and outcome-related factors of perampanel over 12 months in a real-world setting: The FYDATA study by Villanueva, V, Garcés, M, López-González, F.J, Rodriguez-Osorio, X, Toledo, M, Salas-Puig, J, González-Cuevas, M, Campos, D, Serratosa, J.M, Giráldez, B. González, Mauri, J.A, Camacho, J.L, Suller, A, Carreño, M, Gómez, J.B, Montoya, J, Uranga, J. Rodriguez, Saiz-Diaz, R, de la Aleja, J. González, Castillo, A, López-Trigo, J, Poza, J.J, Flores, J, Querol, R, Ojeda, J, Giner, P, Molins, A, Esteve, P, Baiges, J.J

“…Highlights • We report real-world data from 464 patients treated with perampanel over 1 year. • Efficacy and tolerability of perampanel were comparable with…”
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GLUT1 mutations are a rare cause of familial idiopathic generalized epilepsy by STRIANO, P, WEBER, Y. G, POLVI, A, ROBBIANO, A, SERRATOSA, J. M, GUERRINI, R, NÜRNBERG, P, SANDER, T, ZARA, F, LERCHE, H, MARINI, C, TOLIAT, M. R, SCHUBERT, J, LEU, C, CHAIMANA, R, BAULAC, S, GUERRERO, R, LEGUERN, E, LEHESJOKI, A.-E

“…The idiopathic generalized epilepsies (IGE) are the most common genetically determined epilepsies. However, the underlying genes are largely unknown. We…”
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Long-term safety and efficacy of eslicarbazepine acetate in patients with focal seizures: Results of the 1-year ESLIBASE retrospective study by Villanueva, V, Serratosa, J.M, Guillamón, E, Garcés, M, Giráldez, B.G, Toledo, M, Salas-Puig, J, López González, F.J, Flores, J, Rodríguez-Uranga, J, Castillo, A, Mauri, J.A, Camacho, J.L, López-Gomáriz, E, Giner, P, Torres, N, Palau, J, Molins, A

“…Highlights • We evaluated eslicarbazepine acetate (ESL) in a clinical practice setting. • Three hundred and twenty-seven patients with poor seizure control or…”
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High-yield isolation of murine microglia by mild trypsinization by Saura, Josep, Tusell, Josep Maria, Serratosa, Joan

“…Microglia can be isolated with high purity but low yield by shaking off loosely adherent cells from mixed glial cultures. Here we describe a new technique for…”
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Lacosamide monotherapy in clinical practice: A retrospective chart review by Villanueva, V., Giráldez, B. G., Toledo, M., De Haan, G. J., Cumbo, E., Gambardella, A., De Backer, M., Joeres, L., Brunnert, M., Dedeken, P., Serratosa, J.

“…Objective To assess effectiveness and tolerability of first‐line and conversion to lacosamide monotherapy for focal seizures. Materials and Methods…”
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Safety and tolerability of perampanel: a review of clinical trial data by Serratosa, J. M., Villanueva, V., Kerling, F., Kasper, B. S.

“…The Phase II and Phase III clinical development program of perampanel is providing a wealth of data on the safety and tolerability of this…”
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Lafora disease due to EPM2B mutations : A clinical and genetic study by GOMEZ-ABAD, C, GOMEZ-GARRE, P, GUTIERREZ-DELICADO, E, SAYGI, S, MICHELUCCI, R, TASSINARI, C. A, RODRIGUEZ DE CORDOBA, S, SERRATOSA, J. M

“…To study EPM2B gene mutations and genotype-phenotype correlations in patients with Lafora disease. The authors performed a clinical and mutational analysis of…”
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PCAF regulates the stability of the transcriptional regulator and cyclin-dependent kinase inhibitor p27Kip1 by Perez-Luna, M., Aguasca, M., Perearnau, A., Serratosa, J., Martinez-Balbas, M., Jesus Pujol, M., Bachs, O.

“…P27(Kip1) (p27) is a member of the Cip/Kip family of cyclin-dependent kinase inhibitors. Recently, a new function of p27 as transcriptional regulator has been…”
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EFFICACY AND SAFETY OF ESLICARBAZEPINE-ACETATE IN ELDERLY PATIENTS WITH FOCAL EPILEPSY: CASE SERIES by Gómez-Ibáñez, A, Serratosa, J.M, Guillamón, E, Garcés, M, Giráldez, B.G, Toledo, M, Salas-Puig, J, López-González, F.J, Rodríguez-Uranga, J, Castillo, A, Mauri, J.A, Camacho, J.L, López-Gomáriz, E, Giner, P, Torres, N, Palau, J, Molins, A, Villanueva, V

“…Abstract Purpose Eslicarbazepine-acetate (ESL) is a third generation antiepileptic drug licensed as adjunctive therapy in adults with focal seizures. Efficacy…”
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Socio-occupational and employment profile of patients with epilepsy by Marinas, A, Elices, E, Gil-Nagel, A, Salas-Puig, J, Sánchez, J.C, Carreño, M, Villanueva, V, Rosendo, J, Porcel, J, Serratosa, J.M

“…Abstract Objective Epilepsy has a significant impact on quality of life. Many studies have observed higher unemployment rates among patients with epilepsy…”
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Stress response of extensively reared young bulls being transported to growing-finishing farms under Spanish summer commercial conditions by Averós, X., Martín, S., Riu, M., Serratosa, J., Gosálvez, L.F.

“…To evaluate the effect of Spanish summer commercial journeys on the stress response of young bulls born and reared under extensive conditions, 2 replicates of…”
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Novel mutation in STXBP1 gene in a patient with non-lesional Ohtahara syndrome by Ortega-Moreno, L, Giráldez, B G, Verdú, A, García-Campos, O, Sánchez-Martín, G, Serratosa, J M, Guerrero-López, R

“…Ohtahara syndrome (OS, OMIM#308350, ORPHA1934) is an early-onset epileptic encephalopathy (EOEE) characterised by spasms, intractable seizures,…”
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Variant Intestinal-Cell Kinase in Juvenile Myoclonic Epilepsy by Bailey, Julia N, de Nijs, Laurence, Bai, Dongsheng, Suzuki, Toshimitsu, Miyamoto, Hiroyuki, Tanaka, Miyabi, Patterson, Christopher, Lin, Yu-Chen, Medina, Marco T, Alonso, María E, Serratosa, José M, Durón, Reyna M, Nguyen, Viet H, Wight, Jenny E, Martínez-Juárez, Iris E, Ochoa, Adriana, Jara-Prado, Aurelio, Guilhoto, Laura, Molina, Yolly, Yacubian, Elsa M, López-Ruiz, Minerva, Inoue, Yushi, Kaneko, Sunao, Hirose, Shinichi, Osawa, Makiko, Oguni, Hirokazu, Fujimoto, Shinji, Grisar, Thierry M, Stern, John M, Yamakawa, Kazuhiro, Lakaye, Bernard, Delgado-Escueta, Antonio V

“…In this study, variants in the gene encoding intestinal-cell kinase ( ICK ) were associated with 7% of cases of juvenile myoclonic epilepsy among 310 patients…”
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A Novel Protein Tyrosine Phosphatase Gene Is Mutated in Progressive Myoclonus Epilepsy of the Lafora Type (EPM2) by Serratosa, José M., Gómez-Garre, Pilar, Gallardo, Ma Esther, Anta, Berta, de Bernabé, Daniel Beltrán-Valero, Lindhout, Dick, Augustijn, Paul B., Tassinari, Carlo A., Michelucci, Roberto, Malafosse, Alain, Topcu, Meral, Grid, Djamel, Dravet, Charlotte, Berkovic, Samuel F., de Córdoba, Santiago Rodríguez

“…Progressive myoclonus epilepsy of the Lafora type or Lafora disease (EPM2; McKusick no. 254780) is an autosomal recessive disorder characterized by epilepsy,…”
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V28. KCNA2 mutations cause epileptic encephalopathy by gain- or loss-of channel function by Hedrich, U.B.S, Syrbe, S, Riesch, E, Djémié, T, Müller, S, Møller, R.S, Maher, B, Hernandez-Hernandez, L, Synofzik, M, Caglayan, H.S, Arslan, M, Serratosa, J, Gonzalez, M, Züchner, S, Palotie, A, Suls, A, De Jonghe, P, Helbig, I, Biskup, S, Wolff, M, Maljevic, S, Schuele-Freyer, R, Sisodiya, S.M, Weckhuysen, S, Lerche, H, Lemke, J.R

“…Epileptic encephalopathies (EE) are a heterogeneous group of epilepsy syndromes associated with severe cognitive and behavioral disturbances. Amongst others,…”
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Erratum to “Safety, efficacy and outcome-related factors of perampanel over 12months in a real-world setting: The FYDATA study” [Epilepsy Res. 126 (2016) 201–210] by Villanueva, V, Garcés, M, López-González, F.J, Rodriguez-Osorio, X, Toledo, M, Salas-Puig, J, González-Cuevas, M, Campos, D, Serratosa, J.M, González-Giráldez, B, Mauri, J.A, Camacho, J.L, Suller, A, Carreño, M, Gómez, J.B, Montoya, J, Rodríguez-Uranga, J, Saiz-Diaz, R, González-de la Aleja, J, Castillo, A, López-Trigo, J, Poza, J.J, Flores, J, Querol, R, Ojeda, J, Giner, P, Molins, A, Esteve, P, Baigesr, J.J

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Strategies to detect adverse effects of antiepileptic drugs in clinical practice by Carreño, M, Gil-Nagel, A, Sánchez, J.C, Elices, E, Serratosa, J.M, Salas-Puig, J, Villanueva, V, Porcel, J

“…Abstract Objective The aim was to study the frequency and types of adverse effects (AEs) in patients treated with antiepileptic drugs (AEDs) according to the…”
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Hepatic disease as the first manifestation of progressive myoclonus epilepsy of lafora by GOMEZ-GARRE, P, GUTIERREZ-DELICADO, E, GOMEZ-ABAD, C, MORALES-CORRALIZA, J, VILLANUEVA, V. E, RODRIGUEZ DE CORDOBA, S, LARRAURI, J, GUTIERREZ, M, BERCIANO, J, SERRATOSA, J. M

“…Lafora disease (LD; progressive myoclonus epilepsy type 2; EPM2) is an autosomal recessive disorder caused by mutations in the EPM2A and EPM2B genes. LD is…”
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Effect of lamotrigine on sexual function in patients with epilepsy by Gil-Nagel, A., López-Muñoz, F., Serratosa, J.M., Moncada, I., García-García, P., Álamo, C.

“…To assess the course of sexual function in epilepsy patients treated with lamotrigine. This open study included 141 patients treated with lamotrigine for a…”
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