Calcifying nanoparticles associated encrusted urinary bladder cystitis

Encrusted cystitis is a subtype of chronic cystitis characterized by multiple calcifications in the form of plaques located in the interstitium of the urinary bladder mucosa and frequently associated with mucosal ulcers. It is a very rare disease of controversial etiology. Our transmission electron...

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Bibliographic Details
Published in:International journal of nanomedicine Vol. 3; no. 3; pp. 385 - 390
Main Authors: Jelic, Tomislav M, Roque, Rod, Yasar, Uzay, Tomchin, Shayna B, Serrato, Jose M, Deem, Samuel G, Tierney, James P, Chang, Ho-Huang
Format: Journal Article
Language:English
Published: New Zealand Taylor & Francis Ltd 01-01-2008
Dove Press
Dove Medical Press
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Summary:Encrusted cystitis is a subtype of chronic cystitis characterized by multiple calcifications in the form of plaques located in the interstitium of the urinary bladder mucosa and frequently associated with mucosal ulcers. It is a very rare disease of controversial etiology. Our transmission electron microscopy of the calcified plaques of encrusted cystitis has revealed that the smallest formed particles (elementary units) of these calcifications are electron-dense shells surrounding an electron lucent core, diagnostic of calcifying nanoparticles (previously called nanobacteria). We pioneer the notion that calcifying nanoparticles are the causative agents of encrusted urinary bladder cystitis.
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ISSN:1176-9114
1178-2013
1178-2013
DOI:10.2147/IJN.S3559