Search Results - "Serrati, Simona"

The urokinase receptor system, a key regulator at the intersection between inflammation, immunity, and coagulation by Del Rosso, Mario, Margheri, Francesca, Serratì, Simona, Chillà, Anastasia, Laurenzana, Anna, Fibbi, Gabriella

“…The urokinase plasminogen activator (uPA) and its receptor (uPAR) provide a cell surface integrated multimolecular complex that exerts pleiotropic functions…”
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Reproducibility warning: The curious case of polyethylene glycol 6000 and spheroid cell culture by Serrati, Simona, Martinelli, Chiara, Palazzo, Antonio, Iacobazzi, Rosa Maria, Perrone, Mara, Ong, Quy K, Luo, Zhi, Bekdemir, Ahmet, Pinto, Giulia, Cavalleri, Ornella, Cutrignelli, Annalisa, Laquintana, Valentino, Denora, Nunzio, Stellacci, Francesco, Krol, Silke

“…Reproducibility of results is essential for a well-designed and conducted experiment. Several reasons may originate failure in reproducing data, such as…”
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The Fast Track for Intestinal Tumor Cell Differentiation and In Vitro Intestinal Models by Inorganic Topographic Surfaces by Centonze, Matteo, Berenschot, Erwin J W, Serrati, Simona, Susarrey-Arce, Arturo, Krol, Silke

“…Three-dimensional (3D) complex in vitro cell systems are well suited to providing meaningful and translatable results in drug screening, toxicity measurements,…”
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Targeted strategies in the treatment of primary gastric lymphomas: from rituximab to recent insights into potential new drugs by Merchionne, Francesca, Iacopino, Pasquale, Minoia, Carla, Iacobazzi, Angela, Rana, Antonio, Serrati, Simona, De Tullio, Giacoma, Loseto, Giacomo, Lapietra, Angela, Lucarelli, Annunziata, Guarini, Attilio

“…Primary gastric non-Hodgkin's lymphomas (PG-NHL) are the most common extranodal lymphomas, representing between 47% and 74% of all gastrointestinal lymphoma…”
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Circulating extracellular vesicles expressing PD1 and PD-L1 predict response and mediate resistance to checkpoint inhibitors immunotherapy in metastatic melanoma by Serratì, Simona, Guida, Michele, Di Fonte, Roberta, De Summa, Simona, Strippoli, Sabino, Iacobazzi, Rosa Maria, Quarta, Alessandra, De Risi, Ivana, Guida, Gabriella, Paradiso, Angelo, Porcelli, Letizia, Azzariti, Amalia

“…The immunotherapy with immune checkpoints inhibitors (ICI) has changed the life expectancy in metastatic melanoma (MM) patients. Nevertheless, several patients…”
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uPAR-expressing melanoma exosomes promote angiogenesis by VE-Cadherin, EGFR and uPAR overexpression and rise of ERK1,2 signaling in endothelial cells by Biagioni, Alessio, Laurenzana, Anna, Menicacci, Beatrice, Peppicelli, Silvia, Andreucci, Elena, Bianchini, Francesca, Guasti, Daniele, Paoli, Paolo, Serratì, Simona, Mocali, Alessandra, Calorini, Lido, Del Rosso, Mario, Fibbi, Gabriella, Chillà, Anastasia, Margheri, Francesca

“…Exosomes (Exos) have been reported to promote pre-metastatic niche formation, proliferation, angiogenesis and metastasis. We have investigated the role of uPAR…”
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Current Landscape and Future Direction of PD-1/PD-L1 Checkpoint Inhibitors in Cancer Treatment by Serratì, Simona, Margheri, Francesca

“…Immune checkpoints are involved in controlling the activation or inhibition of the immune response and are associated with receptors on the immune cell surface…”
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Enhancing the biological activity of polyoxometalate-peptide nano-fibrils by spacer design by Tagliavini, Valeria, Honisch, Claudia, Serratì, Simona, Azzariti, Amalia, Bonchio, Marcella, Ruzza, Paolo, Carraro, Mauro

“…Polyoxometalates (POMs) and peptides can be conjugated to yield novel bio-hybrids with potential application as nanodrugs. However, the observed POM-induced…”
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Next-generation sequencing: advances and applications in cancer diagnosis by Serratì, Simona, De Summa, Simona, Pilato, Brunella, Petriella, Daniela, Lacalamita, Rosanna, Tommasi, Stefania, Pinto, Rosamaria

“…Technological advances have led to the introduction of next-generation sequencing (NGS) platforms in cancer investigation. NGS allows massive parallel…”
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Microfluidic development and biological evaluation of targeted therapy-loaded biomimetic nano system to improve the metastatic melanoma treatment by Arduino, Ilaria, Di Fonte, Roberta, Tiboni, Mattia, Porcelli, Letizia, Serratì, Simona, Fondaj, Dafina, Rafaschieri, Tania, Cutrignelli, Annalisa, Guida, Gabriella, Casettari, Luca, Azzariti, Amalia, Assunta Lopedota, Angela, Denora, Nunzio, Maria Iacobazzi, Rosa

“…Optimizing current therapies is among next steps in metastatic melanoma (MM) treatment landscape. The innovation of this study is the design of production…”
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Tomatine Displays Antitumor Potential in In Vitro Models of Metastatic Melanoma by Serratì, Simona, Porcelli, Letizia, Guida, Stefania, Ferretta, Anna, Iacobazzi, Rosa Maria, Cocco, Tiziana, Maida, Immacolata, Tamasi, Gabriella, Rossi, Claudio, Manganelli, Michele, Tommasi, Stefania, Azzariti, Amalia, Guida, Gabriella

“…There is a growing interest in the cytotoxic effects of bioactive glycoalkaloids, such as α-tomatine on tumor cells. Here, for the first time, we determine the…”
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Circulating extracellular vesicles are monitoring biomarkers of anti-PD1 response and enhancer of tumor progression and immunosuppression in metastatic melanoma by Serratì, Simona, Di Fonte, Roberta, Porcelli, Letizia, De Summa, Simona, De Risi, Ivana, Fucci, Livia, Ruggieri, Eustachio, Marvulli, Tommaso Maria, Strippoli, Sabino, Fasano, Rossella, Rafaschieri, Tania, Guida, Gabriella, Guida, Michele, Azzariti, Amalia

“…Abstract Background Clinical drawback in checkpoint inhibitors immunotherapy (ICI) of metastatic melanoma (MM) is monitoring clinical benefit. Soluble forms of…”
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CAFs and TGF-β Signaling Activation by Mast Cells Contribute to Resistance to Gemcitabine/Nabpaclitaxel in Pancreatic Cancer by Porcelli, Letizia, Iacobazzi, Rosa Maria, Di Fonte, Roberta, Serratì, Simona, Intini, Angelica, Solimando, Antonio Giovanni, Brunetti, Oronzo, Calabrese, Angela, Leonetti, Francesco, Azzariti, Amalia, Silvestris, Nicola

“…Tumor⁻stroma interactions are of key importance for pancreatic ductal adenocarcinoma (PDAC) progression. Our aim was to investigate whether cancer associated…”
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The ERRα–VDR axis promotes calcitriol degradation and estrogen signaling in breast cancer cells, while VDR‐CYP24A1‐ERRα overexpression correlates with poor prognosis in patients with basal‐like breast cancer by Danza, Katia, Porcelli, Letizia, De Summa, Simona, Di Fonte, Roberta, Pilato, Brunella, Lacalamita, Rosanna, Serratì, Simona, Azzariti, Amalia, Tommasi, Stefania

“…Vitamin D is used to reduce cancer risk and improve the outcome of cancer patients, but the vitamin D receptor (VDR; also known as the calcitriol receptor)…”
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Small-Cell Lung Cancer: Is Liquid Biopsy a New Tool Able to Predict the Efficacy of Immunotherapy? by Fasano, Rossella, Serratì, Simona, Rafaschieri, Tania, Longo, Vito, Di Fonte, Roberta, Porcelli, Letizia, Azzariti, Amalia

“…Small-cell lung cancer (SCLC) cases represent approximately 15% of all lung cancer cases, remaining a recalcitrant malignancy with poor survival and few…”
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uPAR+ extracellular vesicles: a robust biomarker of resistance to checkpoint inhibitor immunotherapy in metastatic melanoma patients by Porcelli, Letizia, Guida, Michele, De Summa, Simona, Di Fonte, Roberta, De Risi, Ivana, Garofoli, Marianna, Caputo, Mariapia, Negri, Antonio, Strippoli, Sabino, Serratì, Simona, Azzariti, Amalia

“…BackgroundEmerging evidence has highlighted the importance of extracellular vesicle (EV)-based biomarkers of resistance to immunotherapy with checkpoint…”
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Microfluidic-Assisted Preparation of Targeted pH-Responsive Polymeric Micelles Improves Gemcitabine Effectiveness in PDAC: In Vitro Insights by Iacobazzi, Rosa Maria, Arduino, Ilaria, Di Fonte, Roberta, Lopedota, Angela Assunta, Serratì, Simona, Racaniello, Giuseppe, Bruno, Viviana, Laquintana, Valentino, Lee, Byung-Chul, Silvestris, Nicola, Leonetti, Francesco, Denora, Nunzio, Porcelli, Letizia, Azzariti, Amalia

“…Pancreatic ductal adenocarcinoma (PDAC) represents a great challenge to the successful delivery of the anticancer drugs. The intrinsic characteristics of the…”
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Endothelial progenitor cell–dependent angiogenesis requires localization of the full-length form of uPAR in caveolae by Margheri, Francesca, Chillà, Anastasia, Laurenzana, Anna, Serratì, Simona, Mazzanti, Benedetta, Saccardi, Riccardo, Santosuosso, Michela, Danza, Giovanna, Sturli, Niccolò, Rosati, Fabiana, Magnelli, Lucia, Papucci, Laura, Calorini, Lido, Bianchini, Francesca, Del Rosso, Mario, Fibbi, Gabriella

“…Endothelial urokinase-type plasminogen activator receptor (uPAR) is thought to provide a regulatory mechanism in angiogenesis. Here we studied the…”
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Hydroxy-Propil-β-Cyclodextrin Inclusion Complexes of two Biphenylnicotinamide Derivatives: Formulation and Anti-Proliferative Activity Evaluation in Pancreatic Cancer Cell Models by Iacobazzi, Rosa Maria, Cutrignelli, Annalisa, Stefanachi, Angela, Porcelli, Letizia, Lopedota, Angela Assunta, Di Fonte, Roberta, Lopalco, Antonio, Serratì, Simona, Laquintana, Valentino, Silvestris, Nicola, Franco, Massimo, Cellamare, Saverio, Leonetti, Francesco, Azzariti, Amalia, Denora, Nunzio

“…Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive malignancies, with poor outcomes largely due to its unique microenvironment, which is…”
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EGFR/uPAR interaction as druggable target to overcome vemurafenib acquired resistance in melanoma cells by Laurenzana, Anna, Margheri, Francesca, Biagioni, Alessio, Chillà, Anastasia, Pimpinelli, Nicola, Ruzzolini, Jessica, Peppicelli, Silvia, Andreucci, Elena, Calorini, Lido, Serratì, Simona, Del Rosso, Mario, Fibbi, Gabriella

“…BRAF inhibitor (BRAF-I) therapy for melanoma patients harboring the V600E mutation is initially highly effective, but almost all patients relapse within a few…”
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