Search Results - "Serrano, João L."

From Xanthine Oxidase Inhibition to In Vivo Hypouricemic Effect: An Integrated Overview of In Vitro and In Vivo Studies with Focus on Natural Molecules and Analogues by Silvestre, Samuel, da Silva Almeida, Paulo Jorge, Serrano, João L., Figueiredo, Joana

“…Hyperuricemia is characterized by elevated uric acid (UA) levels on blood, which can lead to gout, a common pathology. These high UA levels are associated with…”
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Trisubstituted barbiturates and thiobarbiturates: Synthesis and biological evaluation as xanthine oxidase inhibitors, antioxidants, antibacterial and anti-proliferative agents by Figueiredo, Joana, Serrano, João L., Cavalheiro, Eunice, Keurulainen, Leena, Yli-Kauhaluoma, Jari, Moreira, Vânia M., Ferreira, Susana, Domingues, Fernanda C., Silvestre, Samuel, Almeida, Paulo

“…Barbituric and thiobarbituric acid derivatives have become progressively attractive to medicinal chemists due to their wide range of biological activities…”
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An Insight into Symmetrical Cyanine Dyes as Promising Selective Antiproliferative Agents in Caco-2 Colorectal Cancer Cells by Serrano, João L, Maia, Ana, Santos, Adriana O, Lima, Eurico, Reis, Lucinda V, Nunes, Maria J, Boto, Renato E F, Silvestre, Samuel, Almeida, Paulo

“…Cancer remains one of the diseases with the highest worldwide incidence. Several cytotoxic approaches have been used over the years to overcome this public…”
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Nimesulide analogues: From anti-inflammatory to antitumor agents by Catarro, Mafalda, Serrano, João L., Ramos, Susana S., Silvestre, Samuel, Almeida, Paulo

“…[Display omitted] •Nimesulide is an anti-inflammatory drug recently associated to antitumor activity.•The synthesis approaches for nimesulide derivatives is in…”
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Bis-thiobarbiturates as Promising Xanthine Oxidase Inhibitors: Synthesis and Biological Evaluation by Serrano, João L., Lopes, Diana, Reis, Melani J. A., Boto, Renato E. F., Silvestre, Samuel, Almeida, Paulo

“…Xanthine oxidase (XO) is the enzyme responsible for the conversion of endogenous purines into uric acid. Therefore, this enzyme has been associated with…”
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Synthesis and process optimization of symmetric and unsymmetric barbiturates C5-coupled with 2,1-benzisoxazoles by Serrano, João L., Soeiro, Pedro F., Reis, Melani A., Boto, Renato E. F., Silvestre, Samuel, Almeida, Paulo

“…Benzisoxazoles represent an important pharmacophore in medicinal chemistry. Recently, an unexpected formation of symmetric 3-substituted 2,1-benzisoxazoles…”
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5-Hydrazinylethylidenepyrimidines effective against multidrug-resistant Acinetobacter baumannii: Synthesis and in vitro biological evaluation of antibacterial, radical scavenging and cytotoxic activities by Figueiredo, Joana, Serrano, João L., Soares, Mafalda, Ferreira, Susana, Domingues, Fernanda C., Almeida, Paulo, Silvestre, Samuel

“…Acinetobacter baumannii has emerged as an important nosocomial pathogen in recent years, with infectious outbreaks caused by multidrug-resistant strains…”
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