Vitamin E effects on nasal symptoms and serum specific IgE levels in patients with perennial allergic rhinitis

Vitamin E effects on nasal symptoms and serum specific IgE levels in patients with perennial allergic rhinitis

Studies have shown that vitamin E intake may reduce IgE production. To evaluate the effects of vitamin E supplementation on the severity of nasal symptoms and the serum levels of specific IgE in patients with perennial allergic rhinitis. Sixty-three patients (mean +/- SD age, 12 +/- 2.4 years) with...

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Bibliographic Details
Published in:Annals of allergy, asthma, & immunology Vol. 96; no. 1; p. 45
Main Authors: Montaño Velázquez, Bertha Beatriz, Jáuregui-Renaud, Kathrine, Bañuelos Arias, Alejandra del Carmen, Ayala, Julio Cesar, Martínez, Maria Dolores Mogica, Campillo Navarrete, Ramón, Rosalia, Isabel Silvia Vera, Salazar, María del Refugio Cisneros, Serrano, Horacio Alfonso Castilla, Mondragón, Alicia Ocaña, Perez, Rosendo Luria
Format: Journal Article
Language:English
Published: United States 01-01-2006
Subjects:
Adolescent
Adult
Allergens - immunology
Antioxidants - therapeutic use
Child
Dietary Supplements
Double-Blind Method
Ephedrine - therapeutic use
Female
Humans
Immunoglobulin E - blood
Lipid Peroxides - blood
Loratadine - therapeutic use
Male
Rhinitis, Allergic, Perennial - drug therapy
Rhinitis, Allergic, Perennial - immunology
Sneezing - drug effects
Surveys and Questionnaires
Vitamin E - therapeutic use
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Summary:Studies have shown that vitamin E intake may reduce IgE production. To evaluate the effects of vitamin E supplementation on the severity of nasal symptoms and the serum levels of specific IgE in patients with perennial allergic rhinitis. Sixty-three patients (mean +/- SD age, 12 +/- 2.4 years) with a history of perennial allergic rhinitis participated in this study. None of the patients had evidence of acute infectious disease or used tobacco, corticosteroids, antihistamines, or vitamins. Patients were randomized to receive either vitamin E (400 IU/d) or placebo for 4 weeks, with loratadine-pseudoephedrine (0.2/0.5 mg/kg) during the first 2 weeks of treatment. The severity of nasal symptoms was evaluated using a validated questionnaire, which was administered weekly for 4 weeks. The serum concentrations of specific IgE to 5 common inhalant allergens and lipid peroxides were measured before treatment and at the end of the study. Before, during, and after treatment, the symptom severity scores were similar in the 2 groups; within each group, a significant decrease was observed after the first week of follow-up (P < .05), with no further changes. Serum levels of specific IgE and lipid peroxides did not show any significant changes related to vitamin E intake within and between groups. In patients with perennial allergic rhinitis, vitamin E supplementation (400 IU/d) did not have any significant effects on nasal symptom severity or on serum concentrations of specific IgE to 5 common allergens.
ISSN:1081-1206
DOI:10.1016/S1081-1206(10)61039-3