Search Results - "Serrano, Antonin"

Experimental and spontaneous metastasis assays can result in divergence in clonal architecture by Serrano, Antonin, Weber, Tom, Berthelet, Jean, El-Saafin, Farrah, Gadipally, Sreeja, Charafe-Jauffret, Emmanuelle, Ginestier, Christophe, Mariadason, John M., Oakes, Samantha R., Britt, Kara, Naik, Shalin H., Merino, Delphine

“…Intratumoural heterogeneity is associated with poor outcomes in breast cancer. To understand how malignant clones survive and grow in metastatic niches, in…”
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Mastering the use of cellular barcoding to explore cancer heterogeneity by Serrano, Antonin, Berthelet, Jean, Naik, Shalin H., Merino, Delphine

“…Tumours are often composed of a multitude of malignant clones that are genomically unique, and only a few of them may have the ability to escape cancer therapy…”
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Synergistic action of the MCL-1 inhibitor S63845 with current therapies in preclinical models of triple-negative and HER2-amplified breast cancer by Merino, Delphine, Whittle, James R, Vaillant, François, Serrano, Antonin, Gong, Jia-Nan, Giner, Goknur, Maragno, Ana Leticia, Chanrion, Maïa, Schneider, Emilie, Pal, Bhupinder, Li, Xiang, Dewson, Grant, Gräsel, Julius, Liu, Kevin, Lalaoui, Najoua, Segal, David, Herold, Marco J, Huang, David C S, Smyth, Gordon K, Geneste, Olivier, Lessene, Guillaume, Visvader, Jane E, Lindeman, Geoffrey J

“…The development of BH3 mimetics, which antagonize prosurvival proteins of the BCL-2 family, represents a potential breakthrough in cancer therapy. Targeting…”
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Computational Screening of Anti-Cancer Drugs Identifies a New BRCA Independent Gene Expression Signature to Predict Breast Cancer Sensitivity to Cisplatin by Berthelet, Jean, Foroutan, Momeneh, Bhuva, Dharmesh D, Whitfield, Holly J, El-Saafin, Farrah, Cursons, Joseph, Serrano, Antonin, Merdas, Michal, Lim, Elgene, Charafe-Jauffret, Emmanuelle, Ginestier, Christophe, Ernst, Matthias, Hollande, Frédéric, Anderson, Robin L, Pal, Bhupinder, Yeo, Belinda, Davis, Melissa J, Merino, Delphine

“…The development of therapies that target specific disease subtypes has dramatically improved outcomes for patients with breast cancer. However, survival gains…”
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The site of breast cancer metastases dictates their clonal composition and reversible transcriptomic profile by Berthelet, Jean, Wimmer, Verena C, Whitfield, Holly J, Serrano, Antonin, Boudier, Thomas, Mangiola, Stefano, Merdas, Michal, El-Saafin, Farrah, Baloyan, David, Wilcox, Jordan, Wilcox, Steven, Parslow, Adam C, Papenfuss, Anthony T, Yeo, Belinda, Ernst, Matthias, Pal, Bhupinder, Anderson, Robin L, Davis, Melissa J, Rogers, Kelly L, Hollande, Frédéric, Merino, Delphine

“…Intratumoral heterogeneity is a driver of breast cancer progression, but the nature of the clonal interactive network involved in this process remains unclear…”
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