Absolute metabolite quantification by in vivo NMR spectroscopy: V. multicentre quantitative data analysis trial on the overlapping background problem

The goal of this study was to establish the best approach for quantifying nuclear magnetic resonance (NMR) lines, that in the frequency domain are overlapping with broad, unwanted background features. To perform the quantitative data analysis in a controlled way, test signals were designed and utili...

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Bibliographic Details
Published in:Magnetic resonance imaging Vol. 16; no. 9; pp. 1127 - 1137
Main Authors: De Beer, R., Van den Boogaart, A., Cady, E., Graveron-Demilly, D., Knijn, A., Langenberger, K.W., Lindon, J.C., Ohlhoff, A., Serrafi, H., Wylezinska-Arridge, M.
Format: Journal Article
Language:English
Published: Netherlands Elsevier Inc 01-11-1998
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Summary:The goal of this study was to establish the best approach for quantifying nuclear magnetic resonance (NMR) lines, that in the frequency domain are overlapping with broad, unwanted background features. To perform the quantitative data analysis in a controlled way, test signals were designed and utilised, derived from two different real-world in vivo nuclear magnetic resonance signals. One of the main conclusions of the study was that the quantification methods currently available to the biomedical research groups can deliver the correct values of the quantitative parameters, but that great care should be taken in using optimal input parameters for the computer programs concerned.
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ISSN:0730-725X
1873-5894
DOI:10.1016/S0730-725X(98)00121-0