Quercetin prevents insulin dysfunction in hypertensive animals

Angiotensin II induced increase in hypertension enhances oxidative stress and compromises insulin action and pancreatic function. Quercetin-rich foods are beneficial for hypertensive and diabetic animals owing to their antioxidant function. The aim of this study was to evaluate the antioxidant effec...

Full description

Saved in:

Bibliographic Details
Published in:	Journal of diabetes and metabolic disorders Vol. 21; no. 1; pp. 407 - 417
Main Authors:	Serra, Cristiane Alves, dos Reis, Alexandre Freire, Calsa, Bruno, Bueno, Cintia Sena, Helaehil, Júlia Venturini, de Souza, Suelen Aparecida Ribeiro, de Oliveira, Camila Andrea, Vanzella, Emerielle Cristine, do Amaral, Maria Esméria Corezola
Format:	Journal Article
Language:	English
Published:	Cham Springer International Publishing 01-06-2022
Subjects:	Diabetes Endocrinology Medicine Medicine & Public Health Metabolic Diseases Research Article Hypertension Blood vessels Pancreatic islets Muscarinic receptors Insulin sensitivity
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	Angiotensin II induced increase in hypertension enhances oxidative stress and compromises insulin action and pancreatic function. Quercetin-rich foods are beneficial for hypertensive and diabetic animals owing to their antioxidant function. The aim of this study was to evaluate the antioxidant effects of quercetin in hypertensive rats on insulin action, signaling, and secretion. Wistar rats were randomly divided into three groups: sham, hypertensive rats (H), and hypertensive rats supplemented with quercetin (HQ). After three months of initial hypertension, quercetin was administered at 50 mg/kg/day for 30 days. Our results indicate that hypertension and serum lipid peroxidation levels were reduced by quercetin supplementation. We observed increased insulin sensitivity in adipose tissue, corroborating the insulin tolerance test, HOMA index, and improvements in lipid profile. Despite normal insulin secretion at 2.8 and 20 mM of glucose, animals treated with quercetin exhibited increased number of islets per section; increased protein expression of muscarinic receptor type 3, VEGF, and catalase in islets; and hepatic mRNA levels of Ide were normalized. In conclusion, supplementation with quercetin improved insulin action and prevented pancreatic and metabolic dysfunction.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	2251-6581 2251-6581
DOI:	10.1007/s40200-022-00987-4