Search Results - "Seroogy, Joseph J"

Phase I dose-escalation and pharmacokinetic study of ispinesib, a kinesin spindle protein inhibitor, administered on days 1 and 15 of a 28-day schedule in patients with no prior treatment for advanced breast cancer by Gomez, Henry L, Philco, Manuel, Pimentel, Patricia, Kiyan, Miriam, Monsalvo, Maria Laura, Conlan, Maureen G, Saikali, Khalil G, Chen, Michael M, Seroogy, Joseph J, Wolff, Andrew A, Escandon, Rafael D

“…The objective of the study was to evaluate the safety, pharmacokinetics, and antitumor activity of ispinesib, a kinesin spindle protein inhibitor. Patients…”
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A novel monoclonal antibody dependent on domain 5 of the platelet-derived growth factor beta receptor inhibits ligand binding and receptor activation by Ramakrishnan, V, Escobedo, M A, Fretto, L J, Seroogy, J J, Tomlinson, J E, Wolf, D L

“…Platelet derived growth factor (PDGF) induces activation of the protein tyrosine kinase domain of the PDGF receptor, resulting in receptor dimerization and the…”
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Mechanism of platelet-derived growth factor (PDGF) AA, AB, and BB binding to alpha and beta PDGF receptor by FRETTO, L. J, SNAPE, A. J, TOMLINSON, J. E, SEROOGY, J. J, WOLF, D. L, LAROCHELLE, W. J, GIESE, N. A

“…The biological effects of platelet-derived growth factor (PDGF) are mediated by cell surface alpha and beta PDGF receptors, which, as a result of ligand…”
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