Search Results - "Serohijos, Adrian W R"

Non-consecutive enzyme interactions within TCA cycle supramolecular assembly regulate carbon-nitrogen metabolism by Jasinska, Weronika, Dindo, Mirco, Cordoba, Sandra M. C., Serohijos, Adrian W. R., Laurino, Paola, Brotman, Yariv, Bershtein, Shimon

“…Enzymes of the central metabolism tend to assemble into transient supramolecular complexes. However, the functional significance of the interactions,…”
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Author Correction: Non-consecutive enzyme interactions within TCA cycle supramolecular assembly regulate carbon-nitrogen metabolism by Jasinska, Weronika, Dindo, Mirco, Cordoba, Sandra M. C., Serohijos, Adrian W. R., Laurino, Paola, Brotman, Yariv, Bershtein, Shimon

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Phenylalanine-508 mediates a cytoplasmic-membrane domain contact in the CFTR 3D structure crucial to assembly and channel function by Serohijos, Adrian W.R, Hegedűs, Tamás, Aleksandrov, Andrei A, He, Lihua, Cui, Liying, Dokholyan, Nikolay V, Riordan, John R

“…Deletion of phenylalanine-508 (Phe-508) from the N-terminal nucleotide-binding domain (NBD1) of the cystic fibrosis transmembrane conductance regulator (CFTR),…”
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Positively selected sites in cetacean myoglobins contribute to protein stability by Dasmeh, Pouria, Serohijos, Adrian W R, Kepp, Kasper P, Shakhnovich, Eugene I

“…Since divergence ∼50 Ma ago from their terrestrial ancestors, cetaceans underwent a series of adaptations such as a ∼10-20 fold increase in myoglobin (Mb)…”
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Isolation and Analysis of Rare Norovirus Recombinants from Coinfected Mice Using Drop-Based Microfluidics by Zhang, Huidan, Cockrell, Shelley K, Kolawole, Abimbola O, Rotem, Assaf, Serohijos, Adrian W R, Chang, Connie B, Tao, Ye, Mehoke, Thomas S, Han, Yulong, Lin, Jeffrey S, Giacobbi, Nicholas S, Feldman, Andrew B, Shakhnovich, Eugene, Weitz, David A, Wobus, Christiane E, Pipas, James M

“…Human noroviruses (HuNoVs) are positive-sense RNA viruses that can cause severe, highly infectious gastroenteritis. HuNoV outbreaks are frequently associated…”
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The Streptomyces-Produced Antibiotic Fosfomycin Is a Promiscuous Substrate for Archaeal Isopentenyl Phosphate Kinase by Mabanglo, Mark F, Serohijos, Adrian W. R, Poulter, C. Dale

“…Isopentenyl phosphate kinase (IPK) catalyzes the phosphorylation of isopentenyl phosphate to form the isoprenoid precursor isopentenyl diphosphate in the…”
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Protein Homeostasis Imposes a Barrier on Functional Integration of Horizontally Transferred Genes in Bacteria by Bershtein, Shimon, Serohijos, Adrian W R, Bhattacharyya, Sanchari, Manhart, Michael, Choi, Jeong-Mo, Mu, Wanmeng, Zhou, Jingwen, Shakhnovich, Eugene I

“…Horizontal gene transfer (HGT) plays a central role in bacterial evolution, yet the molecular and cellular constraints on functional integration of the foreign…”
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Merging molecular mechanism and evolution: theory and computation at the interface of biophysics and evolutionary population genetics by Serohijos, Adrian W R, Shakhnovich, Eugene I

“…The variation among sequences and structures in nature is both determined by physical laws and by evolutionary history. However, these two factors are…”
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Contribution of selection for protein folding stability in shaping the patterns of polymorphisms in coding regions by Serohijos, Adrian W R, Shakhnovich, Eugene I

“…The patterns of polymorphisms in genomes are imprints of the evolutionary forces at play in nature. In particular, polymorphisms have been extensively used to…”
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Bridging the physical scales in evolutionary biology: from protein sequence space to fitness of organisms and populations by Bershtein, Shimon, Serohijos, Adrian WR, Shakhnovich, Eugene I

“…•Biophysical fitness landscapes (BFL) map fitness to molecular and system-level traits.•BFL of a bacterial enzyme provides accurate prediction of antibiotic…”
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A structural model of the pore-forming region of the skeletal muscle ryanodine receptor (RyR1) by Ramachandran, Srinivas, Serohijos, Adrian W R, Xu, Le, Meissner, Gerhard, Dokholyan, Nikolay V

“…Ryanodine receptors (RyRs) are ion channels that regulate muscle contraction by releasing calcium ions from intracellular stores into the cytoplasm. Mutations…”
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Influenza A H1N1 pandemic strain evolution--divergence and the potential for antigenic drift variants by Klein, Eili Y, Serohijos, Adrian W R, Choi, Jeong-Mo, Shakhnovich, Eugene I, Pekosz, Andrew

“…The emergence of a novel A(H1N1) strain in 2009 was the first influenza pandemic of the genomic age, and unprecedented surveillance of the virus provides the…”
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Multiple Membrane-Cytoplasmic Domain Contacts in the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Mediate Regulation of Channel Gating by He, Lihua, Aleksandrov, Andrei A., Serohijos, Adrian W.R., Hegedüs, Tamás, Aleksandrov, Luba A., Cui, Liying, Dokholyan, Nikolay V., Riordan, John R.

“…The cystic fibrosis transmembrane conductance regulator (CFTR) is a unique ATP-binding cassette (ABC) ion channel mutated in patients with cystic fibrosis. The…”
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A Structural Model Reveals Energy Transduction in Dynein by Serohijos, Adrian W. R., Chen, Yiwen, Ding, Feng, Elston, Timothy C., Dokholyan, Nikolay V.

“…Intracellular active transport is driven by ATP-hydrolyzing motor proteins that move along cytoskeletal filaments. In particular, the microtubule-associated…”
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Evolutionary dynamics of viral escape under antibodies stress: A biophysical model by Chéron, Nicolas, Serohijos, Adrian W.R., Choi, Jeong‐Mo, Shakhnovich, Eugene I.

“…Viruses constantly face the selection pressure of antibodies, either from innate immune response of the host or from administered antibodies for treatment. We…”
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Minimalistic Predictor of Protein Binding Energy: Contribution of Solvation Factor to Protein Binding by Choi, Jeong-Mo, Serohijos, Adrian W.R., Murphy, Sean, Lucarelli, Dennis, Lofranco, Leo L., Feldman, Andrew, Shakhnovich, Eugene I.

“…It has long been known that solvation plays an important role in protein-protein interactions. Here, we use a minimalistic solvation-based model for predicting…”
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Highly Abundant Proteins Favor More Stable 3D Structures in Yeast by Serohijos, Adrian W.R., Lee, S. Y. Ryan, Shakhnovich, Eugene I.

“…To understand the variation of protein sequences in nature, we need to reckon with evolutionary constraints that are biophysical, cellular, and ecological…”
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The Combination of IFN β and TNF Induces an Antiviral and Immunoregulatory Program via Non-Canonical Pathways Involving STAT2 and IRF9 by Mariani, Mélissa K, Dasmeh, Pouria, Fortin, Audray, Caron, Elise, Kalamujic, Mario, Harrison, Alexander N, Hotea, Diana I, Kasumba, Dacquin M, Cervantes-Ortiz, Sandra L, Mukawera, Espérance, Serohijos, Adrian W R, Grandvaux, Nathalie

“…Interferon (IFN) β and Tumor Necrosis Factor (TNF) are key players in immunity against viruses. Compelling evidence has shown that the antiviral and…”
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Identification and rational redesign of peptide ligands to CRIP1, a novel biomarker for cancers by Hao, Jihua, Serohijos, Adrian W R, Newton, Gail, Tassone, Gina, Wang, Zuncai, Sgroi, Dennis C, Dokholyan, Nikolay V, Basilion, James P

“…Cysteine-rich intestinal protein 1 (CRIP1) has been identified as a novel marker for early detection of cancers. Here we report on the use of phage display in…”
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Structural Basis for μ-Opioid Receptor Binding and Activation by Serohijos, Adrian W.R., Yin, Shuangye, Ding, Feng, Gauthier, Josee, Gibson, Dustin G., Maixner, William, Dokholyan, Nikolay V., Diatchenko, Luda

“…Opioids that stimulate the μ-opioid receptor (MOR1) are the most frequently prescribed and effective analgesics. Here we present a structural model of MOR1…”
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