Search Results - "Serno, Tim"

Protein stabilization by cyclodextrins in the liquid and dried state by Serno, Tim, Geidobler, Raimund, Winter, Gerhard

“…Aggregation is arguably the biggest challenge for the development of stable formulations and robust manufacturing processes of therapeutic proteins. In search…”
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Pharmacokinetics, biocompatibility and bioavailability of a controlled release monoclonal antibody formulation by Schweizer, Daniel, Vostiar, Igor, Heier, Annabelle, Serno, Tim, Schoenhammer, Karin, Jahn, Michael, Jones, Stewart, Piequet, Aline, Beerli, Christian, Gram, Hermann, Goepferich, Achim

“…The sustained and localized delivery of monoclonal antibodies has become highly relevant, because of the increasing number of investigated local delivery…”
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Controlled release of therapeutic antibody formats by Schweizer, Daniel, Serno, Tim, Goepferich, Achim

“…•Short antibody residence times of locally administered antibodies are discussed.•Benefits of controlled release systems for therapeutic antibodies are…”
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Not the Usual Suspects: Alternative Surfactants for Biopharmaceuticals by Brosig, Sebastian, Cucuzza, Stefano, Serno, Tim, Bechtold-Peters, Karoline, Buecheler, Jakob, Zivec, Matej, Germershaus, Oliver, Gallou, Fabrice

“…Therapeutically relevant proteins naturally adsorb to interfaces, causing aggregation which in turn potentially leads to numerous adverse consequences such as…”
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Modular and Tunable Alternative Surfactants for Biopharmaceuticals Provide Insights into Surfactant's Structure-Function Relationship by Cucuzza, Stefano, Brosig, Sebastian, Serno, Tim, Bechtold-Peters, Karoline, Cerar, Jure, Kammüller, Michael, Gallou, Fabrice

“…Surface-induced aggregation of protein therapeutics is opposed by employing surfactants, which are ubiquitously used in drug product development, with…”
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Understanding the freezing of biopharmaceuticals: first-principle modeling of the process and evaluation of its effect on product quality by Radmanovic, Nikola, Serno, Tim, Joerg, Susanne, Germershaus, Oliver

“…Freezing and thawing are important process steps in the manufacture of numerous biopharmaceuticals. It is well established that these process steps can…”
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Inhibition of agitation-induced aggregation of an IgG-antibody by hydroxypropyl-beta-cyclodextrin by Serno, Tim, Carpenter, John F, Randolph, Theodore W, Winter, Gerhard

“…In order to provide an alternative to nonionic surfactants as excipients for protein formulations, cyclodextrin-derivatives (CDs) were examined for their…”
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An Intra-Company Analysis of Inherent Particles in Biologicals Shapes the Protein Particle Mitigation Strategy Across Development Stages by Morar-Mitrica, Sorina, Pohl, Thomas, Theisen, Dietmar, Boll, Björn, Bechtold-Peters, Karoline, Schipflinger, Reinhard, Beyer, Beate, Zierow, Swen, Kammüller, Michael, Pribil, Andreas, Schmelzer, Bernhard, Boehm, Stephan, Goetti, Micheline, Serno, Tim

“…To better understand protein aggregation and inherent particle formation in the biologics pipeline at Novartis, a cross-functional team collected and analyzed…”
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The Role of Polysorbate 80 and HPβCD at the Air-Water Interface of IgG Solutions by Serno, Tim, Härtl, Elisabeth, Besheer, Ahmed, Miller, Reinhard, Winter, Gerhard

“…Purpose To test the hypothesis of surface displacement as the underlying mechanism for IgG stabilization by polysorbates and HPβCD against surface-induced…”
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The Role of Polysorbate 80 and HP[beta]CD at the Air-Water Interface of IgG Solutions by Serno, Tim, Härtl, Elisabeth, Besheer, Ahmed, Miller, Reinhard, Winter, Gerhard

“…To test the hypothesis of surface displacement as the underlying mechanism for IgG stabilization by polysorbates and HP[beta]CD against surface-induced…”
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Protein stabilization by cyclodextrins in the liquid and dried state: FORMULATING BIOMOLECULES: MECHANISTICS INSIGHTS IN MOLECULAR INTERACTIONS by SERNO, Tim, GEIDOBLER, Raimund, WINTER, Gerhard

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