Search Results - "Serna, Ivana L."

Epigenetic and pharmacological control of pigmentation via Bromodomain Protein 9 (BRD9) by Basuroy, Tupa, Dreier, Megan, Baum, Caitlin, Blomquist, Thomas, Trumbly, Robert, Filipp, Fabian V., Serna, Ivana L.

“…Lineage‐specific differentiation programs are activated by epigenetic changes in chromatin structure. Melanin‐producing melanocytes maintain a gene expression…”
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BAF60A mediates interactions between the microphthalmia‐associated transcription factor and the BRG1‐containing SWI/SNF complex during melanocyte differentiation by Aras, Shweta, Saladi, Srinivas Vinod, Basuroy, Tupa, Marathe, Himangi G., Lorès, Patrick, Serna, Ivana L.

“…SWI/SNF chromatin remodeling enzymes are multisubunit complexes that contain one of two catalytic subunits, BRG1 or BRM and 9–11 additional subunits called…”
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BRG1 interacts with SOX10 to establish the melanocyte lineage and to promote differentiation by Marathe, Himangi G, Watkins-Chow, Dawn E, Weider, Matthias, Hoffmann, Alana, Mehta, Gaurav, Trivedi, Archit, Aras, Shweta, Basuroy, Tupa, Mehrotra, Aanchal, Bennett, Dorothy C, Wegner, Michael, Pavan, William J, de la Serna, Ivana L

“…Mutations in SOX10 cause neurocristopathies which display varying degrees of hypopigmentation. Using a sensitized mutagenesis screen, we identified Smarca4 as…”
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Targeting SWI/SNF Complexes in Cancer: Pharmacological Approaches and Implications by Dreier, Megan R, Walia, Jasmine, de la Serna, Ivana L

“…SWI/SNF enzymes are heterogeneous multi-subunit complexes that utilize the energy from ATP hydrolysis to remodel chromatin structure, facilitating…”
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SWI/SNF Chromatin Remodeling Enzymes in Melanoma by Dreier, Megan R, de la Serna, Ivana L

“…Melanoma is an aggressive malignancy that arises from the transformation of melanocytes on the skin, mucosal membranes, and uvea of the eye. SWI/SNF chromatin…”
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Chromatin remodelling in mammalian differentiation: lessons from ATP-dependent remodellers by de la Serna, Ivana L, Ohkawa, Yasuyuki, Imbalzano, Anthony N

“…The initiation of cellular differentiation involves alterations in gene expression that depend on chromatin changes, at the level of both higher-order…”
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BRG1 promotes survival of UV-irradiated melanoma cells by cooperating with MITF to activate the melanoma inhibitor of apoptosis gene by Saladi, Srinivas V., Wong, Philip G., Trivedi, Archit R., Marathe, Himangi G., Keenen, Bridget, Aras, Shweta, Liew, Zi-Qi, Setaluri, Vijayasaradhi, de la Serna, Ivana L.

“…Summary Microphthalmia‐associated transcription factor (MITF) is a survival factor in melanocytes and melanoma cells. MITF regulates expression of…”
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Eutherian-Specific Functions of BetaM Acquired through Atp1b4 Gene Co-Option in the Regulation of MyoD Expression by Ahmad, Nisar, de la Serna, Ivana L, Marathe, Himangi G, Fan, Xiaoming, Dube, Prabhatchandra, Zhang, Shungang, Haller, Steven T, Kennedy, David J, Pestov, Nikolay B, Modyanov, Nikolai N

“…Vertebrate genes represent a rare instance of orthologous gene co-option, resulting in radically different functions of the encoded BetaM proteins. In lower…”
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Modulation of extracellular matrix/adhesion molecule expression by BRG1 is associated with increased melanoma invasiveness by Saladi, Srinivas Vinod, Keenen, Bridget, Marathe, Himangi G, Qi, Huiling, Chin, Khew-Voon, de la Serna, Ivana L

“…Metastatic melanoma is an aggressive malignancy that is resistant to therapy and has a poor prognosis. The progression of primary melanoma to metastatic…”
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Bromodomain and extra-terminal domain (BET) proteins regulate melanocyte differentiation by Trivedi, Archit, Mehrotra, Aanchal, Baum, Caitlin E, Lewis, Brandon, Basuroy, Tupa, Blomquist, Thomas, Trumbly, Robert, Filipp, Fabian V, Setaluri, Vijayasaradhi, de la Serna, Ivana L

“…Pharmacologic inhibition of bromodomain and extra-terminal (BET) proteins is currently being explored as a new therapeutic approach in cancer. Some studies…”
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SWI/SNF enzymes promote SOX10- mediated activation of myelin gene expression by Marathe, Himangi G, Mehta, Gaurav, Zhang, Xiaolu, Datar, Ila, Mehrotra, Aanchal, Yeung, Kam C, de la Serna, Ivana L

“…SOX10 is a Sry-related high mobility (HMG)-box transcriptional regulator that promotes differentiation of neural crest precursors into Schwann cells,…”
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MyoD Targets Chromatin Remodeling Complexes to the Myogenin Locus Prior to Forming a Stable DNA-Bound Complex by de la Serna, Ivana L., Ohkawa, Yasuyuki, Berkes, Charlotte A., Bergstrom, Donald A., Dacwag, Caroline S., Tapscott, Stephen J., Imbalzano, Anthony N.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Mammalian SWI/SNF complexes promote MyoD-mediated muscle differentiation by Imbalzano, Anthony N, de la Serna, Ivana L, Carlson, Kerri A

“…Mammalian SWI/SNF complexes are ATP-dependent chromatin remodeling enzymes that have been implicated in the regulation of gene expression, cell-cycle control…”
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The Microphthalmia-associated Transcription Factor Requires SWI/SNF Enzymes to Activate Melanocyte-specific Genes by de la Serna, Ivana L., Ohkawa, Yasuyuki, Higashi, Chiduru, Dutta, Chaitali, Osias, Jules, Kommajosyula, Naveen, Tachibana, Taro, Imbalzano, Anthony N.

“…The microphthalmia transcription factor (Mitf) activates melanocyte-specific gene expression, is critical for survival and proliferation of melanocytes during…”
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MITF interacts with the SWI/SNF subunit, BRG1, to promote GATA4 expression in cardiac hypertrophy by Mehta, Gaurav, Kumarasamy, Sivarajan, Wu, Jian, Walsh, Aaron, Liu, Lijun, Williams, Kandace, Joe, Bina, de la Serna, Ivana L

“…Abstract The transcriptional regulation of pathological cardiac hypertrophy involves the interplay of transcription factors and chromatin remodeling enzymes…”
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Chromatin remodeling in Embryonic stem cells: Regulating the balance between pluripotency and differentiation by Keenen, Bridget, de la Serna, Ivana L.

“…Embryonic stem cells have an unlimited potential for self‐renewal yet are pluripotent, capable of differentiating into three different germ layers and…”
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SWI/SNF chromatin remodeling enzymes are associated with cardiac hypertrophy in a genetic rat model of hypertension by Mehrotra, Aanchal, Joe, Bina, de la Serna, Ivana L.

“…Pathological cardiac hypertrophy is characterized by a sustained increase in cardiomyocyte size and re‐activation of the fetal cardiac gene program. Previous…”
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SWItching on the transcriptional circuitry in melanoma by Vinod Saladi, Srinivas, Marathe, Himangi, de la Serna, Ivana L.

“…Melanoma is an aggressive malignancy that is resistant to current therapy, and the most lethal of all human skin cancers. It is characterized by several…”
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SETD7 in cardiomyocyte differentiation and cardiac function by Basuroy, Tupa, de la Serna, Ivana L.

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ATP Dependent Chromatin Remodeling Enzymes in Embryonic Stem Cells by Saladi, Srinivas Vinod, de la Serna, Ivana L.

“…Embryonic stem (ES) cells are pluripotent cells that can self renew or be induced to differentiate into multiple cell lineages, and thus have the potential to…”
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