Search Results - "Serkova, Natalie J."

Nanoparticle-Based Magnetic Resonance Imaging on Tumor-Associated Macrophages and Inflammation by Serkova, Natalie J

“…The inflammatory response, mediated by tissue-resident or newly recruited macrophages, is an underlying pathophysiological condition for many diseases,…”
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Mechanisms and Barriers in Cancer Nanomedicine: Addressing Challenges, Looking for Solutions by Anchordoquy, Thomas J, Barenholz, Yechezkel, Boraschi, Diana, Chorny, Michael, Decuzzi, Paolo, Dobrovolskaia, Marina A, Farhangrazi, Z. Shadi, Farrell, Dorothy, Gabizon, Alberto, Ghandehari, Hamidreza, Godin, Biana, La-Beck, Ninh M, Ljubimova, Julia, Moghimi, S. Moein, Pagliaro, Len, Park, Ji-Ho, Peer, Dan, Ruoslahti, Erkki, Serkova, Natalie J, Simberg, Dmitri

“…Remarkable progress has recently been made in the synthesis and characterization of engineered nanoparticles for imaging and treatment of cancers, resulting in…”
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Clinical Applications of Metabolomics in Oncology: A Review by SPRATLIN, Jennifer L, SERKOVA, NatalieJ, GAIL ECKHARDT, S

“…Metabolomics, an omic science in systems biology, is the global quantitative assessment of endogenous metabolites within a biological system. Either…”
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The Emerging Field of Quantitative Blood Metabolomics for Biomarker Discovery in Critical Illnesses by SERKOVA, Natalie J, STANDIFORD, Theodore J, STRINGER, Kathleen A

“…Metabolomics, a science of systems biology, is the global assessment of endogenous metabolites within a biologic system and represents a "snapshot" reading of…”
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Subversion of Systemic Glucose Metabolism as a Mechanism to Support the Growth of Leukemia Cells by Ye, Haobin, Adane, Biniam, Khan, Nabilah, Alexeev, Erica, Nusbacher, Nichole, Minhajuddin, Mohammad, Stevens, Brett M., Winters, Amanda C., Lin, Xi, Ashton, John M., Purev, Enkhtsetseg, Xing, Lianping, Pollyea, Daniel A., Lozupone, Catherine A., Serkova, Natalie J., Colgan, Sean P., Jordan, Craig T.

“…From an organismal perspective, cancer cell populations can be considered analogous to parasites that compete with the host for essential systemic resources…”
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Aging-associated inflammation promotes selection for adaptive oncogenic events in B cell progenitors by Henry, Curtis J, Casás-Selves, Matias, Kim, Jihye, Zaberezhnyy, Vadym, Aghili, Leila, Daniel, Ashley E, Jimenez, Linda, Azam, Tania, McNamee, Eoin N, Clambey, Eric T, Klawitter, Jelena, Serkova, Natalie J, Tan, Aik Choon, Dinarello, Charles A, DeGregori, James

“…The incidence of cancer is higher in the elderly; however, many of the underlying mechanisms for this association remain unexplored. Here, we have shown that B…”
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Metabolic Reprogramming Regulates the Proliferative and Inflammatory Phenotype of Adventitial Fibroblasts in Pulmonary Hypertension Through the Transcriptional Corepressor C-Terminal Binding Protein-1 by Li, Min, Riddle, Suzette, Zhang, Hui, D’Alessandro, Angelo, Flockton, Amanda, Serkova, Natalie J, Hansen, Kirk C, Moldvan, Radu, McKeon, B Alexandre, Frid, Maria, Kumar, Sushil, Li, Hong, Liu, Hongbing, Caánovas, Angela, Medrano, Juan F, Thomas, Milton G, Iloska, Dijana, Plecitá-Hlavatá, Lydie, Ježek, Petr, Pullamsetti, Soni, Fini, Mehdi A, El Kasmi, Karim C, Zhang, QingHong, Stenmark, Kurt R

“…BACKGROUND:Changes in metabolism have been suggested to contribute to the aberrant phenotype of vascular wall cells, including fibroblasts, in pulmonary…”
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Phase I Pharmacologic and Biologic Study of Ramucirumab (IMC-1121B), a Fully Human Immunoglobulin G1 Monoclonal Antibody Targeting the Vascular Endothelial Growth Factor Receptor-2 by SPRATLIN, Jennifer L, COHEN, Roger B, MEROPOL, Neal J, LEWIS, Nancy L, CHIOREAN, E. Gabriela, FOX, Floyd, YOUSSOUFIAN, Hagop, ROWINSKY, Eric K, GAIL ECKHARDT, S, EADENS, Matthew, GORE, Lia, CAMIDGE, D. Ross, DIAB, Sami, LEONG, Stephen, O'BRYANT, Cindy, CHOW, Laura Q. M, SERKOVA, Natalie J

“…PURPOSE To evaluate the safety, maximum-tolerated dose (MTD), pharmacokinetics (PKs), pharmacodynamics, and preliminary anticancer activity of ramucirumab…”
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Rapid P-TEFb-dependent transcriptional reorganization underpins the glioma adaptive response to radiotherapy by Walker, Faye M., Sobral, Lays Martin, Danis, Etienne, Sanford, Bridget, Donthula, Sahiti, Balakrishnan, Ilango, Wang, Dong, Pierce, Angela, Karam, Sana D., Kargar, Soudabeh, Serkova, Natalie J., Foreman, Nicholas K., Venkataraman, Sujatha, Dowell, Robin, Vibhakar, Rajeev, Dahl, Nathan A.

“…Dynamic regulation of gene expression is fundamental for cellular adaptation to exogenous stressors. P-TEFb-mediated pause-release of RNA polymerase II (Pol…”
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Comprehensive assessment of blood–brain barrier opening and sterile inflammatory response: unraveling the therapeutic window by Martinez, Payton J., Song, Jane J., Garay, Francis G., Song, Kang-Ho, Mufford, Toni, Steiner, Jenna, DeSisto, John, Ellens, Nicholas, Serkova, Natalie J., Green, Adam L., Borden, Mark

“…Microbubbles (MBs) combined with focused ultrasound (FUS) has emerged as a promising noninvasive technique to permeabilize the blood–brain barrier (BBB) for…”
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Folate dietary insufficiency and folic acid supplementation similarly impair metabolism and compromise hematopoiesis by Henry, Curtis J, Nemkov, Travis, Casás-Selves, Matias, Bilousova, Ganna, Zaberezhnyy, Vadym, Higa, Kelly C, Serkova, Natalie J, Hansen, Kirk C, D'Alessandro, Angelo, DeGregori, James

“…While dietary folate deficiency is associated with increased risk for birth defects and other diseases, evidence suggests that supplementation with folic acid…”
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Super Elongation Complex as a Targetable Dependency in Diffuse Midline Glioma by Dahl, Nathan A., Danis, Etienne, Balakrishnan, Ilango, Wang, Dong, Pierce, Angela, Walker, Faye M., Gilani, Ahmed, Serkova, Natalie J., Madhavan, Krishna, Fosmire, Susan, Green, Adam L., Foreman, Nicholas K., Venkataraman, Sujatha, Vibhakar, Rajeev

“…Histone 3 gene mutations are the eponymous drivers in diffuse midline gliomas (DMGs), aggressive pediatric brain cancers for which no curative therapy…”
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Therapeutic targets and biomarkers identified in cancer choline phospholipid metabolism by Glunde, Kristine, Serkova, Natalie J

“…Choline phospholipid metabolism is altered in a wide variety of cancers. The choline metabolite profile of tumors and cancer cells is characterized by an…”
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Cabozantinib Exhibits Potent Antitumor Activity in Colorectal Cancer Patient-Derived Tumor Xenograft Models via Autophagy and Signaling Mechanisms by Scott, Aaron J, Arcaroli, John J, Bagby, Stacey M, Yahn, Rachel, Huber, Kendra M, Serkova, Natalie J, Nguyen, Anna, Kim, Jihye, Thorburn, Andrew, Vogel, Jon, Quackenbush, Kevin S, Capasso, Anna, Schreiber, Anna, Blatchford, Patrick, Klauck, Peter J, Pitts, Todd M, Eckhardt, S Gail, Messersmith, Wells A

“…Antiangiogenic therapy used in treatment of metastatic colorectal cancer (mCRC) inevitably succumbs to treatment resistance. Upregulation of MET may play an…”
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A novel preclinical model of craniospinal irradiation in pediatric diffuse midline glioma demonstrates decreased metastatic disease by Knox, Aaron J, Van Court, Benjamin, Oweida, Ayman, Barsh, Elinor, DeSisto, John, Flannery, Patrick, Lemma, Rakeb, Chatwin, Hannah, Vibhakar, Rajeev, Dorris, Kathleen, Serkova, Natalie J, Karam, Sana D, Gilani, Ahmed, Green, Adam L

“…Diffuse midline glioma (DMG) is an aggressive pediatric central nervous system tumor with strong metastatic potential. As localized treatment of the primary…”
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Metabolic Imaging to Assess Treatment Response to Cytotoxic and Cytostatic Agents by Serkova, Natalie J, Eckhardt, S Gail

“…For several decades, cytotoxic chemotherapeutic agents were considered the basis of anticancer treatment for patients with metastatic tumors. A decrease in…”
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Inositol Hexaphosphate Inhibits Tumor Growth, Vascularity, and Metabolism in TRAMP Mice: A Multiparametric Magnetic Resonance Study by RAINA, Komal, RAVICHANDRAN, Kameswaran, RAJAMANICKAM, Subapriya, HUBER, Kendra M, SERKOVA, Natalie J, AGARWAL, Rajesh

“…Herein, employing anatomical and dynamic contrast-enhanced (DCE) magnetic resonance imaging (MRI), we evaluated noninvasively, the in vivo, chemopreventive…”
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Abnormalities in glucose uptake and metabolism in imatinib-resistant human BCR-ABL-positive cells by Kominsky, Douglas J, Klawitter, Jelena, Brown, Jaimi L, Boros, Laszlo G, Melo, Junia V, Eckhardt, S Gail, Serkova, Natalie J

“…The development of imatinib resistance has become a significant therapeutic problem in which the etiology seems to be multifactorial and poorly understood. As…”
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Unique Heterogeneous Topological Pattern of the Metabolic Landscape in Rabbit Fetal Lungs following Tracheal Occlusion by Marwan, Ahmed I, Shabeka, Uladzimir, Reisz, Julie A, Zheng, Connie, Serkova, Natalie J, Dobrinskikh, Evgenia

“…Fetal tracheal occlusion (TO) is currently an experimental approach to drive accelerated lung growth. It is stimulated by mechanotransduction that results in…”
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Induction of the unfolded protein response drives enhanced metabolism and chemoresistance in glioma cells by Epple, Laura M, Dodd, Rebecca D, Merz, Andrea L, Dechkovskaia, Anjelika M, Herring, Matthew, Winston, Benjamin A, Lencioni, Alex M, Russell, Rae L, Madsen, Helen, Nega, Meheret, Dusto, Nathaniel L, White, Jason, Bigner, Darell D, Nicchitta, Christopher V, Serkova, Natalie J, Graner, Michael W

“…The unfolded protein response (UPR) is an endoplasmic reticulum (ER)-based cytoprotective mechanism acting to prevent pathologies accompanying protein…”
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