Search Results - "Serkov, Igor V."

New Hybrids of 4-Amino-2,3-polymethylene-quinoline and p -Tolylsulfonamide as Dual Inhibitors of Acetyl- and Butyrylcholinesterase and Potential Multifunctional Agents for Alzheimer's Disease Treatment by Makhaeva, Galina F, Kovaleva, Nadezhda V, Boltneva, Natalia P, Lushchekina, Sofya V, Astakhova, Tatiana Yu, Rudakova, Elena V, Proshin, Alexey N, Serkov, Igor V, Radchenko, Eugene V, Palyulin, Vladimir A, Bachurin, Sergey O, Richardson, Rudy J

“…New hybrid compounds of 4-amino-2,3-polymethylene-quinoline containing different sizes of the aliphatic ring and linked to -tolylsulfonamide with alkylene…”
Get full text

New Multifunctional Agents Based on Conjugates of 4-Amino-2,3-polymethylenequinoline and Butylated Hydroxytoluene for Alzheimer's Disease Treatment by Makhaeva, Galina F, Kovaleva, Nadezhda V, Rudakova, Elena V, Boltneva, Natalia P, Lushchekina, Sofya V, Faingold, Irina I, Poletaeva, Darya A, Soldatova, Yuliya V, Kotelnikova, Raisa A, Serkov, Igor V, Ustinov, Anatoly K, Proshin, Alexey N, Radchenko, Eugene V, Palyulin, Vladimir A, Richardson, Rudy J

“…New hybrids of 4-amino-2,3-polymethylenequinoline with different sizes of the aliphatic ring linked to butylated hydroxytoluene (BHT) by enaminoalkyl ( ) or…”
Get full text

Bis-Amiridines as Acetylcholinesterase and Butyrylcholinesterase Inhibitors: N -Functionalization Determines the Multitarget Anti-Alzheimer's Activity Profile by Makhaeva, Galina F, Kovaleva, Nadezhda V, Boltneva, Natalia P, Rudakova, Elena V, Lushchekina, Sofya V, Astakhova, Tatiana Yu, Serkov, Igor V, Proshin, Alexey N, Radchenko, Eugene V, Palyulin, Vladimir A, Korabecny, Jan, Soukup, Ondrej, Bachurin, Sergey O, Richardson, Rudy J

“…Using two ways of functionalizing amiridine-acylation with chloroacetic acid chloride and reaction with thiophosgene-we have synthesized new homobivalent…”
Get full text

Combining Experimental and Computational Methods to Produce Conjugates of Anticholinesterase and Antioxidant Pharmacophores with Linker Chemistries Affecting Biological Activities Related to Treatment of Alzheimer's Disease by Makhaeva, Galina F, Kovaleva, Nadezhda V, Rudakova, Elena V, Boltneva, Natalia P, Lushchekina, Sofya V, Astakhova, Tatiana Y, Timokhina, Elena N, Serkov, Igor V, Proshin, Alexey N, Soldatova, Yuliya V, Poletaeva, Darya A, Faingold, Irina I, Mumyatova, Viktoriya A, Terentiev, Alexey A, Radchenko, Eugene V, Palyulin, Vladimir A, Bachurin, Sergey O, Richardson, Rudy J

“…Effective therapeutics for Alzheimer's disease (AD) are in great demand worldwide. In our previous work, we responded to this need by synthesizing novel drug…”
Get full text

In Vivo Targeted Metabolomic Profiling of Prostanit, a Novel Anti-PAD NO-Donating Alprostadil-Based Drug by Shestakova, Ksenia M, Moskaleva, Natalia E, Mesonzhnik, Natalia V, Kukharenko, Alexey V, Serkov, Igor V, Lyubimov, Igor I, Fomina-Ageeva, Elena V, Bezuglov, Vladimir V, Akimov, Mikhail G, Appolonova, Svetlana A

“…Prostanit is a novel drug developed for the treatment of peripheral arterial diseases. It consists of a prostaglandin E (PGE ) moiety with two nitric oxide…”
Get full text

Arachidonoylcholine and Other Unsaturated Long-Chain Acylcholines Are Endogenous Modulators of the Acetylcholine Signaling System by Akimov, Mikhail G, Kudryavtsev, Denis S, Kryukova, Elena V, Fomina-Ageeva, Elena V, Zakharov, Stanislav S, Gretskaya, Natalia M, Zinchenko, Galina N, Serkov, Igor V, Makhaeva, Galina F, Boltneva, Natalia P, Kovaleva, Nadezhda V, Serebryakova, Olga G, Lushchekina, Sofya V, Palikov, Victor A, Palikova, Yulia, Dyachenko, Igor A, Kasheverov, Igor E, Tsetlin, Victor I, Bezuglov, Vladimir V

“…Cholines acylated with unsaturated fatty acids are a recently discovered family of endogenous lipids. However, the data on the biological activity of…”
Get full text

LC-MS/MS Identification and Structural Characterization of Main Biodegradation Products of Nitroproston - A Novel Prostaglandin-based Pharmaceutical Compound by Mesonzhnik, Natalia V, Moskaleva, Natalia E, Shestakova, Ksenia M, Kurynina, Ksenya O, Baranov, Pavel A, Gretskaya, Natalia M, Serkov, Igor V, Lyubimov, Igor I, Bezuglov, Vladimir V, Appolonova, Svetlana A

“…Nitroproston is a novel prostaglandin-based compound modified by NOdonating groups with potential application in obstructive respiratory diseases such as…”
Get more information

Synthesis, molecular docking and biological evaluation of N,N-disubstituted 2-aminothiazolines as a new class of butyrylcholinesterase and carboxylesterase inhibitors by Makhaeva, Galina F., Boltneva, Natalia P., Lushchekina, Sofya V., Serebryakova, Olga G., Stupina, Tatyana S., Terentiev, Alexey A., Serkov, Igor V., Proshin, Alexey N., Bachurin, Sergey O., Richardson, Rudy J.

“…[Display omitted] A series of 31 N,N-disubstituted 2-amino-5-halomethyl-2-thiazolines was designed, synthesized, and evaluated for inhibitory potential against…”
Get full text

Conjugates of tacrine and 1,2,4-thiadiazole derivatives as new potential multifunctional agents for Alzheimer’s disease treatment: Synthesis, quantum-chemical characterization, molecular docking, and biological evaluation by Makhaeva, Galina F., Kovaleva, Nadezhda V., Boltneva, Natalia P., Lushchekina, Sofya V., Rudakova, Elena V., Stupina, Tatyana S., Terentiev, Alexey A., Serkov, Igor V., Proshin, Alexey N., Radchenko, Eugene V., Palyulin, Vladimir A., Bachurin, Sergey O., Richardson, Rudy J.

“…[Display omitted] •New conjugates of tacrine with 1,2,4-thiadiazole derivatives were synthesized.•Extensive QM characterization revealed most stable forms of…”
Get full text

Novel bexarotene derivatives: Synthesis and cytotoxicity evaluation for glioma cells in 2D and 3D in vitro models by Gretskaya, Natalia M., Gamisonia, Alina M., Dudina, Polina V., Zakharov, Stanislav S., Sherstyanykh, Galina, Akasov, Roman, Burov, Sergey, Serkov, Igor V., Akimov, Mikhail G., Bezuglov, Vladimir V., Markvicheva, Elena

“…Glioblastoma (GBM) is an aggressive and lethal form of brain cancer with a high invasion capacity and a lack of effective chemotherapeutics. Retinoid…”
Get full text

Amiridine-piperazine hybrids as cholinesterase inhibitors and potential multitarget agents for Alzheimer's disease treatment by Makhaeva, Galina F., Lushchekina, Sofya V., Kovaleva, Nadezhda V., Yu. Astakhova, Tatiana, Boltneva, Natalia P., Rudakova, Elena V., Serebryakova, Olga G., Proshin, Alexey N., Serkov, Igor V., Trofimova, Tatiana P., Tafeenko, Victor A., Radchenko, Eugene V., Palyulin, Vladimir A., Fisenko, Vladimir P., Korábečný, Jan, Soukup, Ondrej, Richardson, Rudy J.

“…[Display omitted] •Eleven novel amiridine-piperazine hybrids were synthesized by a new method.•Lead compounds potently inhibited AChE and displaced propidium…”
Get full text

Corrigendum to “Conjugates of tacrine and 1,2,4-thiadiazole derivatives as new potential multifunctional agents for Alzheimer's disease treatment: Synthesis, quantum-chemical characterization, molecular docking, and biological evaluation”. [Bioorg. Chem. 94C (2019)] by Makhaeva, Galina F., Kovaleva, Nadezhda V., Boltneva, Natalia P., Lushchekina, Sofya V., Rudakova, Elena V., Stupina, Tatyana S., Terentiev, Alexey A., Serkov, Igor V., Proshin, Alexey N., Radchenko, Eugene V., Palyulin, Vladimir A., Bachurin, Sergey O., Richardson, Rudy J.

Get full text

Rabbit plasma metabolomic analysis of Nitroproston®: a multi target natural prostaglandin based-drug by Shestakova, Ksenia, Brito, Alex, Mesonzhnik, Natalia V., Moskaleva, Natalia E., Kurynina, Ksenia O., Grestskaya, Natalia M., Serkov, Igor V., Lyubimov, Igor I., Bezuglov, Vladimir V., Appolonova, Svetlana A.

“…Introduction Nitroproston® is a novel multi-target drug bearing natural prostaglandin E 2 (PGE 2 ) and nitric oxide (NO)-donating fragments for treatment of…”
Get full text

Novel conjugates of 4-amino-2,3-polymethylenequinolines and vanillin as potential multitarget agents for AD treatment by Makhaeva, Galina F., Serkov, Igor V., Kovaleva, Nadezhda V., Rudakova, Elena V., Boltneva, Natalia P., Kochetkova, Ekaterina A., Proshin, Alexey N., Bachurin, Sergey O.

“…[Display omitted] A series of novel conjugates of 4-amino-2,3-polymethylene quinolines and phenolic antioxidant vanillin was synthesized by the condensation of…”
Get full text