Search Results - "Serizawa, Isao"

orally-active and selective c-Fms tyrosine kinase inhibitor Ki20227 inhibits disease progression in a collagen-induced arthritis mouse model by Ohno, Hiroaki, Uemura, Yasunori, Murooka, Hideko, Takanashi, Hiromi, Tokieda, Takemi, Ohzeki, Yumiko, Kubo, Kazuo, Serizawa, Isao

“…Macrophage colony-stimulating factor (M-CSF) is important in the development of macrophages and osteoclasts. Previous studies have also shown that CD11b⁺…”
Get full text

Germinated barley foodstuff, a prebiotic product, ameliorates inflammation of colitis through modulation of the enteric environment by Kanauchi, Osamu, Serizawa, Isao, Araki, Yoshio, Suzuki, Asuka, Andoh, Akira, Fujiyama, Yoshihide, Mitsuyama, Keiichi, Takaki, Kosuke, Toyonaga, Atsushi, Sata, Michio, Bamba, Tadao

“…Germinated barley foodstuff (GBF), which contains glutamine-rich protein and hemicellulose-rich fiber, exhibits therapeutic effects in ulcerative colitis;…”
Get full text

An Essential Role of Mast Cells in the Development of Airway Hyperresponsiveness in a Murine Asthma Model by Kobayashi, Tetsuto, Miura, Toru, Haba, Tomoko, Sato, Miyuki, Serizawa, Isao, Nagai, Hiroichi, Ishizaka, Kimishige

“…Immunization of BALB/c mice with alum-adsorbed OVA, followed by three bronchoprovocations with aerosolized OVA, resulted in the development of airway…”
Get full text

Differential Effects of β2-Adrenoceptor Desensitization on the IgE-Dependent Release of Chemical Mediators from Cultured Human Mast Cells by Tsuji, Toshikazu, Kato, Toshinobu, Kimata, Masahiro, Miura, Toru, Serizawa, Isao, Inagaki, Naoki, Nagai, Hiroichi

“…In the present study, we examined the inhibitory effects of the β2-adrenoceptor agonists isoproterenol, salbutamol, fenoterol, and clenbuterol, on the release…”
Get full text

Roles of mitogen-activated protein kinase pathways for mediator release from human cultured mast cells by Kimata, Masahiro, Inagaki, Naoki, Kato, Toshinobu, Miura, Toru, Serizawa, Isao, Nagai, Hiroichi

“…Human cultured mast cells (HCMC) secrete histamine, sulfidoleukotrienes (LTs), and prostaglandin D 2 (PGD 2), and produce a variety of cytokines after…”
Get full text

Ca2+and Protein Kinase C Signaling for Histamine and Sulfidoleukotrienes Released from Human Cultured Mast Cells by Kimata, Masahiro, Shichijo, Michitaka, Miura, Toru, Serizawa, Isao, Inagaki, Naoki, Nagai, Hiroichi

“…Human cultured mast cells (HCMC) release histamine and sulfidoleukotrienes (LTs) upon IgE-FcϵRI-mediated mast cell activation. We analyzed the Ca2+and PKC…”
Get full text

Differential effects of beta2-adrenoceptor desensitization on the IgE-dependent release of chemical mediators from cultured human mast cells by Tsuji, Toshikazu, Kato, Toshinobu, Kimata, Masahiro, Miura, Toru, Serizawa, Isao, Inagaki, Naoki, Nagai, Hiroichi

“…In the present study, we examined the inhibitory effects of the beta2-adrenoceptor agonists isoproterenol, salbutamol, fenoterol, and clenbuterol, on the…”
Get full text

A Comparative Study of Isolation-Induced Ultrasonic Vocalization in Rodent Pups by MOTOMURA, Nobuko, SHIMIZU, Keiko, SHIMIZU, Makoto, AOKI-KOMORI, Shinobu, TANIGUCHI, Kazumi, SERIZAWA, Isao, SAITO, Toru R.

“…The purpose of this study was to determine whether species differences in neonatal vocalizations of rodent pups could be observed. Ultrasonic vocalizations of…”
Get full text

Role of protein kinase A in the inhibition of human mast cell histamine release by β-adrenergic receptor agonists by Kato, Toshinobu, Kimata, Masahiro, Tsuji, Toshikazu, Shichijo, Michitaka, Murata, Masayuki, Miura, Toru, Serizawa, Isao, Inagaki, Naoki, Nagai, Hiroichi

“…Although β-adrenergic receptor agonists inhibit antigen-induced release of histamine, leukotrienes and prostaglandin D2 from human lung fragments, dispersed…”
Get full text

Lipid antigen presentation in the immune system; lessons learned from CD 1 d knockout mice by Hong, Seokmann, Scherer, David C., Singh, Nagendra, Mendiratta, Sanjeev K., Serizawa, Isao, Koezuka, Yasuhiko, Van Kaer, Luc

“…CD I molecules represent a distinct lineage of antigen‐presenting molecules chat are evolutionarily related to the classical major histocompatility complex…”
Get full text

Inherent and antigen-induced airway hyperreactivity in NC mice by Kobayashi, Tetsuto, Miura, Toru, Haba, Tomoko, Sato, Miyuki, Takei, Masao, Serizawa, Isao

“…In order to clarify the airway physiology of NC mice, the following experiments were carried out. To investigate inherent airway reactivity, we compared…”
Get full text

The natural killer T-cell ligand α-galactosylceramide prevents autoimmune diabetes in non-obese diabetic mice by Van Kaer, Luc, Hong, Seokmann, Wilson, Michael T, Serizawa, Isao, Wu, Lan, Singh, Nagendra, Naidenko, Olga V, Miura, Toru, Haba, Tomoku, Scherer, David C, Wei, Jie, Kronenberg, Mitchell, Koezuka, Yasuhiko

“…Diabetes in non-obese diabetic (NOD) mice is mediated by pathogenic T-helper type 1 (Th1) cells that arise because of a deficiency in regulatory or suppressor…”
Get full text

CD52 is a novel costimulatory molecule for induction of CD4 + regulatory T cells by Watanabe, Tomoko, Masuyama, Jun-ichi, Sohma, Yoshiaki, Inazawa, Hiroko, Horie, Kaori, Kojima, Kumiko, Uemura, Yasunori, Aoki, Yumi, Kaga, Shuji, Minota, Seiji, Tanaka, Toshiyuki, Yamaguchi, Yasunori, Kobayashi, Tetsuto, Serizawa, Isao

“…We previously reported that 4C8 monoclonal antibody (mAb) provides a costimulatory signal to human CD4 + T cells and consequently induces regulatory T (Treg)…”
Get full text

Functional Natural Killer T Cells in Experimental Mouse Strains, Including NK1.1- Strains by SERIZAWA, Isao, KOEZUKA, Yasuhiko, AMAO, Hiromi, SAITO, Toru R., TAKAHASHI, Kazuaki W.

“…Natural killer T (NKT) cells are a newly discovered subset of lymphocytes. It appears that this subset has potential as important regulators of immune…”
Get full text

Cutting edge: activation of NK T cells by CD1d and alpha-galactosylceramide directs conventional T cells to the acquisition of a Th2 phenotype by Singh, N, Hong, S, Scherer, D C, Serizawa, I, Burdin, N, Kronenberg, M, Koezuka, Y, Van Kaer, L

“…NK T cells recognize glycolipid Ags such as alpha-galactosylceramide (alpha-GalCer) presented by the MHC class I-like molecule CD1d. In this paper we have…”
Get full text

β2 Integrin-dependent tyrosine phosphorylation of proline-rich tyrosine kinase 2 in platelet-activating factor-activated eosinophils by Ohashi, Hiroshi, Takei, Masao, Kita, Hirohito, Gleich, Gerald J, Serizawa, Isao, Fukamachi, Hiromi

“…Platelet-activating factor (PAF) can activate various cellular functions, including degranulation in eosinophils. In the present study, we examined tyrosine…”
Get full text

Quantitative and qualitative differences in the in vivo response of NKT cells to distinct alpha- and beta-anomeric glycolipids by Parekh, Vrajesh V, Singh, Avneesh K, Wilson, Michael T, Olivares-Villagómez, Danyvid, Bezbradica, Jelena S, Inazawa, Hiroko, Ehara, Hiromi, Sakai, Teruyuki, Serizawa, Isao, Wu, Lan, Wang, Chyung-Ru, Joyce, Sebastian, Van Kaer, Luc

“…NKT cells represent a unique subset of immunoregulatory T cells that recognize glycolipid Ags presented by the MHC class I-like molecule CD1d. Because of their…”
Get full text

The selective M-CSF receptor tyrosine kinase inhibitor Ki20227 suppresses experimental autoimmune encephalomyelitis by Uemura, Yasunori, Ohno, Hiroaki, Ohzeki, Yumiko, Takanashi, Hiromi, Murooka, Hideko, Kubo, Kazuo, Serizawa, Isao

“…Abstract Experimental autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis (MS), can be induced by the immunization of mice with myelin…”
Get full text

Treatment With Anti‐γ‐Glutamyl Transpeptidase Antibody Attenuates Osteolysis in Collagen‐Induced Arthritis Mice by Ishizuka, Yasuyuki, Moriwaki, Sawako, Kawahara‐Hanaoka, Miyuki, Uemura, Yasunori, Serizawa, Isao, Miyauchi, Mutsumi, Shibata, Shunichi, Kanaya, Toshimichi, Takata, Takashi, Taniguchi, Naoyuki, Niida, Shumpei

“…The effectiveness of a new antibody treatment on arthritis‐associated osteolysis was studied by using CIA mice. GGT, a newly identified bone‐resorbing factor,…”
Get full text

Lipid antigen presentation in the immune system: lessons learned from CD1d knockout mice by Hong, S, Scherer, D C, Singh, N, Mendiratta, S K, Serizawa, I, Koezuka, Y, Van Kaer, L

“…CD1 molecules represent a distinct lineage of antigen-presenting molecules that are evolutionarily related to the classical major histocompatibility complex…”
Get full text