Search Results - "Serio, R"

[PIN+]ing down the mechanism of prion appearance by Serio, Tricia R

“…Prions are conformationally flexible proteins capable of adopting a native state and a spectrum of alternative states associated with a change in the function…”
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The prion hypothesis: from biological anomaly to basic regulatory mechanism by Tuite, Mick F, Serio, Tricia R

“…Key Points An expanding group of proteins, known as prions, has been identified in fungi and mammals. Prions have the ability to confer unique phenotypes on…”
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Beyond Amyloid Fibers: Accumulation, Biological Relevance, and Regulation of Higher-Order Prion Architectures by Naeimi, Wesley R, Serio, Tricia R

“…The formation of amyloid fibers is associated with a diverse range of disease and phenotypic states. These amyloid fibers often assemble into…”
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Nucleated Conformational Conversion and the Replication of Conformational Information by a Prion Determinant by Serio, Tricia R., Cashikar, Anil G., Kowal, Anthony S., Sawicki, George J., Moslehi, Jahan J., Serpell, Louise, Arnsdorf, Morton F., Lindquist, Susan L.

“…Prion proteins can serve as genetic elements by adopting distinct physical and functional states that are self-perpetuating and heritable. The critical region…”
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Multiple aspects of amyloid dynamics in vivo integrate to establish prion variant dominance in yeast by Norton, Jennifer, Seah, Nicole, Santiago, Fabian, Sindi, Suzanne S, Serio, Tricia R

“…Prion variants are self-perpetuating conformers of a single protein that assemble into amyloid fibers and confer unique phenotypic states. Multiple prion…”
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A Size Threshold Limits Prion Transmission and Establishes Phenotypic Diversity by Derdowski, Aaron, Sindi, Suzanne S., Klaips, Courtney L., DiSalvo, Susanne, Serio, Tricia R.

“…According to the prion hypothesis, atypical phenotypes arise when a prion protein adopts an alternative conformation and persist when that form assembles into…”
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A dominant-negative mutant inhibits multiple prion variants through a common mechanism by Pei, Fen, DiSalvo, Susanne, Sindi, Suzanne S, Serio, Tricia R

“…Prions adopt alternative, self-replicating protein conformations and thereby determine novel phenotypes that are often irreversible. Nevertheless,…”
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Amyloid-associated activity contributes to the severity and toxicity of a prion phenotype by Pezza, John A., Villali, Janice, Sindi, Suzanne S., Serio, Tricia R.

“…The self-assembly of alternative conformations of normal proteins into amyloid aggregates has been implicated in both the acquisition of new functions and in…”
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Angiotensin II type II receptors and colonic dysmotility in 2,4‐dinitrofluorobenzenesulfonic acid‐induced colitis in rats by Zizzo, M. G., Auteri, M., Amato, A., Caldara, G., Nuzzo, D., Di Carlo, M., Serio, R.

“…Background Angiotensin II (Ang II), the main peptide of the renin‐angiotensin system (RAS), has been suggested to be involved in inflammatory bowel diseases…”
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Peripheral motor action of glucagon‐like peptide‐1 through enteric neuronal receptors by Amato, A., Cinci, L., Rotondo, A., Serio, R., Faussone‐pellegrini, M. S., Vannucchi, M. G., Mulè, F.

“…Background  Glucagon‐like peptide‐1 (GLP‐1) is a proglucagon‐derived peptide expressed in the enteroendocrine‐L cells of small and large intestine and released…”
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Distinct Prion Domain Sequences Ensure Efficient Amyloid Propagation by Promoting Chaperone Binding or Processing In Vivo by Langlois, Christine R, Pei, Fen, Sindi, Suzanne S, Serio, Tricia R

“…Prions are a group of proteins that can adopt a spectrum of metastable conformations in vivo. These alternative states change protein function and are…”
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Spatial quality control bypasses cell-based limitations on proteostasis to promote prion curing by Klaips, Courtney L, Hochstrasser, Megan L, Langlois, Christine R, Serio, Tricia R

“…The proteostasis network has evolved to support protein folding under normal conditions and to expand this capacity in response to proteotoxic stresses…”
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Hsp104-dependent remodeling of prion complexes mediates protein-only inheritance by Satpute-Krishnan, Prasanna, Langseth, Sara X, Serio, Tricia R

“…Inheritance of phenotypic traits depends on two key events: replication of the determinant of that trait and partitioning of these copies between mother and…”
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Angiotensin II contractile effects in mouse colon: role for pre- and post-junctional AT1A receptors by Mastropaolo, M., Zizzo, M. G., Mulè, F., Serio, R.

“…Aim This study investigates whether a local renin–angiotensin system (RAS) exists in mouse colon and whether angiotensin II (Ang II) may play a role in the…”
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Activation of angiotensin II type 1 receptors and contractile activity in human sigmoid colon in vitro by Mastropaolo, M., Zizzo, M. G., Auteri, M., Caldara, G., Liotta, R., Mulè, F., Serio, R.

“…Aim To analyse the effects of angiotensin II (Ang II) on the contractility of human sigmoid colon, and to characterize the subtype(s) of receptor(s) involved…”
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Adenosine negatively regulates duodenal motility in mice: role of A(1) and A(2A) receptors by Zizzo, M G, Mastropaolo, M, Lentini, L, Mulè, F, Serio, R

“…Adenosine is considered to be an important modulator of intestinal motility. This study was undertaken to investigate the role of adenosine in the modulation…”
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Prion protein remodelling confers an immediate phenotypic switch by Satpute-Krishnan, Prasanna, Serio, Tricia R

“…In a variety of systems, proteins have been linked to processes historically limited to nucleic acids, such as infectivity and inheritance. These atypical…”
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Adenosine negatively regulates duodenal motility in mice: role of A 1 and A 2A receptors by Zizzo, MG, Mastropaolo, M, Lentini, L, Mulè, F, Serio, R

“…BACKGROUND AND PURPOSE Adenosine is considered to be an important modulator of intestinal motility. This study was undertaken to investigate the role of…”
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Interaction between cannabinoid CB 1 receptors and endogenous ATP in the control of spontaneous mechanical activity in mouse ileum by Baldassano, S, Zizzo, MG, Serio, R, Mulè, F

“…Background and purpose:  Although it is well accepted that cannabinoids modulate intestinal motility by reducing cholinergic neurotransmission mediated by CB 1…”
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Inhibitory purinergic transmission in mouse caecum: Role for P2Y1 receptors as prejunctional modulators of ATP release by Zizzo, M.G, Mulè, F, Serio, R

“…Using conventional microelectrode recording techniques, we investigated, in the circular muscle of the mouse caecum, the neurotransmitter(s) involved in the…”
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