Antioxidant and Protective Effects of Oleaster Oil Against Silica Nanoparticle-Induced Oxidative Stress and Organ Toxicity in Rats

Nanoparticles have found widespread application in a variety of fields, despite growing worry about their possible hazardous effects on both the environment and human health. In recent years, research efforts have focused on plants and vegetable oils, which have been identified as abundant sources o...

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Bibliographic Details
Published in:	Applied sciences Vol. 14; no. 21; p. 10046
Main Authors:	Hamdiken, Malika, Bouzitouna, Amina, Hami, Manel, Seridi, Yousra, Grara, Nedjoud, Ayed, Hayette, Boudjahem, Abdelghani, Zebsa, Rabah, Di Pierro, Prospero, Balivo, Andrea, Genovese, Alessandro
Format:	Journal Article
Language:	English
Published:	Basel MDPI AG 01-11-2024
Subjects:	Antioxidants Cosmetics cytotoxicity Dietary fiber Ethylenediaminetetraacetic acid Fatty acids Flavonoids Glutathione transferase Health aspects hepatotoxicity Lipid peroxidation Lung diseases Nanomaterials Nanoparticles Occupational health and safety Oleaceae oleaster oil Olive oil Oxidative stress Silica silica nanoparticles Superoxide Toxicity Tuberculosis Vegetable oils VOCs Volatile organic compounds Algeria United States > US
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Summary:	Nanoparticles have found widespread application in a variety of fields, despite growing worry about their possible hazardous effects on both the environment and human health. In recent years, research efforts have focused on plants and vegetable oils, which have been identified as abundant sources of many bioactive compounds. Many of these substances are known to participate in antioxidant processes. As a result, the current study was designed to investigate the antioxidant and protective properties of oleaster oil against cytotoxicity and oxidative stress induced by silica nanoparticles (SiNPs) in albino Wistar rats. Forty male rats were randomly assigned to four equally sized cohorts: a control group, SiNP-treated group (at a dose of 50 mg/kg), SiNP-treated group supplemented with oleaster oil (at a dose of 2 mL/kg), and those receiving only 2 mL/kg of oleaster oil. The findings demonstrated that SiNPs initiated an oxidative stress environment, as evidenced by higher lipid peroxidation levels and changes in antioxidant defense mechanisms. Antioxidant enzymes were significantly reduced, including glutathione levels between the control and SiNP-exposure treatments (36.01%, 36.59%, 60%), glutathione-S-transferase (29.74%, 29.90%, 13.49%), catalase (24.14%, 28.19%, 30.85%), and tissue superoxide dismutase (11.90%, 37.78%, 37.79%) in the liver, kidney, and heart, respectively. Furthermore, histological investigations revealed significant liver, kidney, and heart damage, as indicated by pathological alterations such as vascular dilatation and congestion, inflammatory cellular infiltration, and hepatocellular dysfunction. Encouragingly, the administration of oleaster oil significantly ameliorated a majority of these detrimental effects. These data suggest a potential protective effect of oleaster oil against the adverse histological effects induced by SiNP injection.
ISSN:	2076-3417 2076-3417
DOI:	10.3390/app142110046