Search Results - "Serhan, Nizar"

Adrenomedullin-CALCRL axis controls relapse-initiating drug tolerant acute myeloid leukemia cells by Larrue, Clément, Guiraud, Nathan, Mouchel, Pierre-Luc, Dubois, Marine, Farge, Thomas, Gotanègre, Mathilde, Bosc, Claudie, Saland, Estelle, Nicolau-Travers, Marie-Laure, Sabatier, Marie, Serhan, Nizar, Sahal, Ambrine, Boet, Emeline, Mouche, Sarah, Heydt, Quentin, Aroua, Nesrine, Stuani, Lucille, Kaoma, Tony, Angenendt, Linus, Mikesch, Jan-Henrik, Schliemann, Christoph, Vergez, François, Tamburini, Jérôme, Récher, Christian, Sarry, Jean-Emmanuel

“…Drug tolerant/resistant leukemic stem cell (LSC) subpopulations may explain frequent relapses in acute myeloid leukemia (AML), suggesting that these…”
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Identification of a tumor-promoter cholesterol metabolite in human breast cancers acting through the glucocorticoid receptor by Voisin, Maud, de Medina, Philippe, Mallinger, Arnaud, Dalenc, Florence, Huc-Claustre, Emilie, Leignadier, Julie, Serhan, Nizar, Soules, Régis, Ségala, Grégory, Mougel, Aurélie, Noguer, Emmanuel, Mhamdi, Loubna, Bacquié, Elodie, Iuliano, Luigi, Zerbinati, Chiara, Lacroix-Triki, Magali, Chaltiel, Léonor, Filleron, Thomas, Cavaillès, Vincent, Saati, Talal Al, Rochaix, Philippe, Duprez-Paumier, Raphaelle, Franchet, Camille, Ligat, Laetitia, Lopez, Fréderic, Record, Michel, Poirot, Marc, Silvente-Poirot, Sandrine

“…Breast cancer (BC) remains the primary cause of death from cancer among women worldwide. Cholesterol-5,6-epoxide (5,6-EC) metabolism is deregulated in BC but…”
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Dendrogenin A drives LXR to trigger lethal autophagy in cancers by Segala, Gregory, David, Marion, de Medina, Philippe, Poirot, Mathias C., Serhan, Nizar, Vergez, François, Mougel, Aurelie, Saland, Estelle, Carayon, Kevin, Leignadier, Julie, Caron, Nicolas, Voisin, Maud, Cherier, Julia, Ligat, Laetitia, Lopez, Frederic, Noguer, Emmanuel, Rives, Arnaud, Payré, Bruno, Saati, Talal al, Lamaziere, Antonin, Despres, Gaëtan, Lobaccaro, Jean-Marc, Baron, Silvere, Demur, Cecile, de Toni, Fabienne, Larrue, Clément, Boutzen, Helena, Thomas, Fabienne, Sarry, Jean-Emmanuel, Tosolini, Marie, Picard, Didier, Record, Michel, Récher, Christian, Poirot, Marc, Silvente-Poirot, Sandrine

“…Dendrogenin A (DDA) is a newly discovered cholesterol metabolite with tumor suppressor properties. Here, we explored its efficacy and mechanism of cell death…”
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Increased atherosclerosis in P2Y13/apolipoprotein E double-knockout mice: contribution of P2Y13 to reverse cholesterol transport by Lichtenstein, Laeticia, Serhan, Nizar, Espinosa-Delgado, Sara, Fabre, Aurélie, Annema, Wijtske, Tietge, Uwe J F, Robaye, Bernard, Boeynaems, Jean-Marie, Laffargue, Muriel, Perret, Bertrand, Martinez, Laurent O

“…High-density lipoproteins (HDLs) protect against atherosclerosis mainly due to their function in hepatobiliary reverse cholesterol transport (RCT). This is a…”
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Combined Treatments of Magnetic Intra-Lysosomal Hyperthermia with Doxorubicin Promotes Synergistic Anti-Tumoral Activity by El Hajj Diab, Darine, Clerc, Pascal, Serhan, Nizar, Fourmy, Daniel, Gigoux, Véronique

“…Doxorubicin is a cytotoxic drug used for the treatment of many cancer types. However, its significant dose-related adverse effects including cardiotoxicity may…”
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Resveratrol plus ethanol counteract the ethanol-induced impairment of energy metabolism: 31P NMR study of ATP and sn-glycerol-3-phosphate on isolated and perfused rat liver by Gallis, Jean-Louis, Serhan, Nizar, Gin, Henri, Couzigou, Patrice, Beauvieux, Marie-Christine

“…The effects of trans-resveratrol (RSV) combined with ethanol (EtOH) were evaluated by 31P NMR on total ATP and sn-glycerol-3-phosphate (sn-G3P) contents…”
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Chemotherapy-Resistant Human Acute Myeloid Leukemia Cells Are Not Enriched for Leukemic Stem Cells but Require Oxidative Metabolism by Farge, Thomas, Saland, Estelle, de Toni, Fabienne, Aroua, Nesrine, Hosseini, Mohsen, Perry, Robin, Bosc, Claudie, Sugita, Mayumi, Stuani, Lucille, Fraisse, Marine, Scotland, Sarah, Larrue, Clément, Boutzen, Héléna, Féliu, Virginie, Nicolau-Travers, Marie-Laure, Cassant-Sourdy, Stéphanie, Broin, Nicolas, David, Marion, Serhan, Nizar, Sarry, Audrey, Tavitian, Suzanne, Kaoma, Tony, Vallar, Laurent, Iacovoni, Jason, Linares, Laetitia K, Montersino, Camille, Castellano, Rémy, Griessinger, Emmanuel, Collette, Yves, Duchamp, Olivier, Barreira, Yara, Hirsch, Pierre, Palama, Tony, Gales, Lara, Delhommeau, François, Garmy-Susini, Barbara H, Portais, Jean-Charles, Vergez, François, Selak, Mary, Danet-Desnoyers, Gwenn, Carroll, Martin, Récher, Christian, Sarry, Jean-Emmanuel

“…Chemotherapy-resistant human acute myeloid leukemia (AML) cells are thought to be enriched in quiescent immature leukemic stem cells (LSC). To validate this…”
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Abstract 2657: Immune checkpoint therapy as a treatment option for non-muscle invasive bladder cancer by Benmerzoug, Sulayman, Louche, Katie, Angles, Thibault, Serhan, Nizar, Dol-Gleizes, Frederique, Lejeune, Pascale, Chabot, Sophie

“…Abstract Bladder cancer (BCa) is one of the most common malignancies with more than 500,000 new cases diagnosed each year. Intravesical instillations of…”
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Magneto-mechanical destruction of cancer-associated fibroblasts using ultra-small iron oxide nanoparticles and low frequency rotating magnetic fields by Lopez, Sara, Hallali, Nicolas, Lalatonne, Yoann, Hillion, Arnaud, Antunes, Joana C, Serhan, Nizar, Clerc, Pascal, Fourmy, Daniel, Motte, Laurence, Carrey, Julian, Gigoux, Véronique

“…The destruction of cells using the mechanical activation of magnetic nanoparticles with low-frequency magnetic fields constitutes a recent and interesting…”
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Antileukemic Activity of 2-Deoxy-d-Glucose through Inhibition of N-Linked Glycosylation in Acute Myeloid Leukemia with FLT3-ITD or c-KIT Mutations by Larrue, Clément, Saland, Estelle, Vergez, François, Serhan, Nizar, Delabesse, Eric, Mansat-De Mas, Véronique, Hospital, Marie-Anne, Tamburini, Jérôme, Manenti, Stéphane, Sarry, Jean Emmanuel, Récher, Christian

“…We assessed the antileukemic activity of 2-deoxy-d-glucose (2-DG) through the modulation of expression of receptor tyrosine kinases (RTK) commonly mutated in…”
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Chronic pharmacological activation of P2Y13 receptor in mice decreases HDL-cholesterol level by increasing hepatic HDL uptake and bile acid secretion by Serhan, Nizar, Cabou, Cendrine, Verdier, Céline, Lichtenstein, Laeticia, Malet, Nicole, Perret, Bertrand, Laffargue, Muriel, Martinez, Laurent O.

“…High level of high-density lipoprotein cholesterol (HDL-cholesterol) is inversely correlated to the risk of atherosclerotic cardiovascular disease. The…”
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P2Y13 receptor is critical for reverse cholesterol transport by Fabre, Aurélie C., Malaval, Camille, Ben Addi, Abduelhakem, Verdier, Céline, Pons, Véronique, Serhan, Nizar, Lichtenstein, Laeticia, Combes, Guillaume, Huby, Thierry, Briand, François, Collet, Xavier, Nijstad, Niels, Tietge, Uwe J.F., Robaye, Bernard, Perret, Bertrand, Boeynaems, Jean‐Marie, Martinez, Laurent O.

“…A major atheroprotective functionality of high‐density lipoproteins (HDLs) is to promote “reverse cholesterol transport” (RCT). In this process, HDLs mediate…”
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Dendrogenin A Synergizes with Cytarabine to Kill Acute Myeloid Leukemia Cells In Vitro and In Vivo by Serhan, Nizar, Mouchel, Pierre-Luc, de Medina, Philippe, Segala, Gregory, Mougel, Aurélie, Saland, Estelle, Rives, Arnaud, Lamaziere, Antonin, Despres, Gaëtan, Sarry, Jean-Emmanuel, Larrue, Clément, Vergez, François, Largeaud, Laetitia, Record, Michel, Récher, Christian, Silvente-Poirot, Sandrine, Poirot, Marc

“…Dendrogenin A (DDA) is a mammalian cholesterol metabolite that displays potent antitumor properties on acute myeloid leukemia (AML). DDA triggers lethal…”
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Quantitative analysis of the tumor suppressor dendrogenin A using liquid chromatography tandem mass spectrometry by Noguer, Emmanuel, Soules, Régis, Netter, Claude, Nagarathinam, Citra, Leignadier, Julie, Huc-Claustre, Emilie, Serhan, Nizar, Rives, Arnaud, de Medina, Philippe, Silvente-Poirot, Sandrine, Poirot, Marc

“…•Dendrogenin A is a polycationic amino-oxysterol.•We have developed a new RP LC/MS method for DDA analysis that is fast, sensitive and selective.•This novel…”
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Resveratrol mainly stimulates the glycolytic ATP synthesis flux and not the mitochondrial one: A saturation transfer NMR study in perfused and isolated rat liver by Beauvieux, Marie-Christine, Stephant, Alan, Gin, Henri, Serhan, Nizar, Couzigou, Patrice, Gallis, Jean-Louis

“…Our aim was to monitor the effects of resveratrol (RSV) on the respective contribution of glycolysis and oxidative phosphorylation on the unidirectional flux…”
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Dendrogenin A Enhances Anti-Leukemic Effect of Anthracycline in Acute Myeloid Leukemia by Mouchel, Pierre-Luc, Serhan, Nizar, Betous, Rémy, Farge, Thomas, Saland, Estelle, De Medina, Philippe, Hoffmann, Jean-Sébastien, Sarry, Jean-Emmanuel, Poirot, Marc, Silvente-Poirot, Sandrine, Récher, Christian

“…Dendrogenin A (DDA), a mammalian cholesterol metabolite with tumor suppressor properties, has recently been shown to exhibit strong anti-leukemic activity in…”
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Role of the ubiquitin-proteasome system in the regulation of P2Y^sub 13^ receptor expression: impact on hepatic HDL uptake by Pons, Véronique, Serhan, Nizar, Gayral, Stéphanie, Malaval, Camille, Nauze, Michel, Malet, Nicole, Laffargue, Muriel, Galés, Céline, Martinez, Laurent O

“…The protective effect of high density lipoproteins (HDL) against atherosclerosis is mainly attributed to their capacity to transport excess cholesterol from…”
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The Combination of ATRA and Dasatinib for Differentiation Therapy in Acute Myeloid Leukemias with IDH Mutations by Boutzen, Helena, Saland, Estelle, Cathebras, Mathilde, Larrue, Clément, Farge, Thomas, Serhan, Nizar, De Toni, Fabienne, David, Marion, Gales, Lara, Castelli, Florence, Junot, Christophe, Delabesse, Eric, Veronique, Demas, Portais, Jean-Charles, Ouerfelli, Ouathek, Guangli, Yang, Vergez, Francois, Recher, Christian, Sarry, Jean-Emmanuel

“…Acute myeloid leukemia (AML) is characterized by the accumulation of malignant blasts with impaired differentiation programs due to recurrent mutations,…”
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Role of the ubiquitin–proteasome system in the regulation of P2Y₁₃ receptor expression: impact on hepatic HDL uptake by Pons, Véronique, Serhan, Nizar, Gayral, Stéphanie, Malaval, Camille, Nauze, Michel, Malet, Nicole, Laffargue, Muriel, Galés, Céline, Martinez, Laurent O

“…The protective effect of high density lipoproteins (HDL) against atherosclerosis is mainly attributed to their capacity to transport excess cholesterol from…”
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Dendrogenin_A : A Natural Liver X Receptor Modulator for the Treatment of Acute Myeloid Leukemia by Recher, Christian, David, Marion, de Medina, Philippe, Bize, Cécile, Serhan, Nizar, Paillasse, Michael R, Saland, Estelle, Noguer, Emmanuel, Cherier, Julia, Demur, Cécile, Larrue, Clément, de Toni, Fabienne, Vergez, François, Sarry, Jean-emmanuel, Silvente-Poirot, Sandrine, Poirot, Marc

“…Acute Myeloid Leukemia (AML) is the most common type of leukemia in adults. Despite intensive research, current treatments remain unsatisfactory with only 40%…”
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