Search Results - "Serguera, C"

Gene therapy of the central nervous system: General considerations on viral vectors for gene transfer into the brain by Serguera, C., Bemelmans, A.-P.

“…The last decade has nourished strong doubts on the beneficial prospects of gene therapy for curing fatal diseases. However, this climate of reservation is…”
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OP66 – 2883: Anti MOG antibodies, complement and inflammatory cytokines in demyelinating diseases in children: A French cohort study by Deiva, K, Keo, V, Serguera, C, Horellou, P

“…Objective Inflammatory demyelinating diseases (DMD) in children are frequently associated with presence of anti-MOG antibodies and some of them may be the…”
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Efficient Transduction of Neural Cells In Vitro and In Vivo by a Baculovirus-Derived Vector by Sarkis, C, Serguera, C, Petres, S, Buchet, D, Ridet, J L, Edelman, L, Mallet, J

“…Gene delivery to the central nervous system is central to the development of gene therapy for neurological diseases. We developed a baculovirus-derived vector,…”
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Ephemeral gene medicine for the brain by Mallet, Jacques, Serguera, Che

“…Whether gene therapy will be successful in curing human diseases remains an open question. Nonetheless, powerful tools have been developed for its application,…”
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The HIV-1 DNA flap stimulates HIV vector-mediated cell transduction in the brain by Charneau, Pierre, Zennou, Véronique, Serguera, Ché, Sarkis, Chamsy, Colin, Philippe, Perret, Emmanuelle, Mallet, Jacques

“…During HIV-1 reverse transcription, central initiation of the plus-strand DNA at the central polypurine tract (cPPT) and central termination at the central…”
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Integration of genetically modified adult astrocytes into the lesioned rat spinal cord by Pencalet, Philippe, Serguera, Che, Corti, Olga, Privat, Alain, Mallet, Jacques, Giménez y Ribotta, Minerva

“…Combination of ex vivo gene transfer and cell transplantation is now considered as a potentially useful strategy for the treatment of spinal cord injury. In a…”
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Long-Term Expression of β-Glucuronidase by Genetically Modified Human Neural Progenitor Cells Grafted into the Mouse Central Nervous System by Buchet, Delphine, Serguera, Ché, Zennou, Véronique, Charneau, Pierre, Mallet, Jacques

“…Mucopolysaccharidosis type VII (MPS VII) is an inherited disease caused by β-glucuronidase (β-glu) deficiency. This deficiency results in the lysosomal…”
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Control of erythropoietin secretion by doxycycline or mifepristone in mice bearing polymer-encapsulated engineered cells by Serguera, C, Bohl, D, Rolland, E, Prevost, P, Heard, J M

“…Cell encapsulation offers a safe and manufacturable method for the systemic delivery of therapeutic proteins from genetically engineered cells. However,…”
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Influence of insulators on transgene expression from integrating and non-integrating lentiviral vectors by Grandchamp, Nicolas, Henriot, Dorothée, Philippe, Stéphanie, Amar, Lahouari, Ursulet, Suzanna, Serguera, Che, Mallet, Jacques, Sarkis, Chamsy

“…The efficacy and biosafety of lentiviral gene transfer is influenced by the design of the vector. To this end, properties of lentiviral vectors can be modified…”
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Transplantation of human adult astrocytes: Efficiency and safety requirements for an autologous gene therapy by Ridet, Jean-Luc, Sarkis, Chamsy, Serguera, Che, Zennou, Véronique, Charneau, Pierre, Mallet, Jacques

“…Ex vivo gene therapy is emerging as a promising approach for the treatment of neurodegenerative diseases and central nervous system (CNS) trauma. We have shown…”
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Primary Adult Human Astrocytes as an ex Vivo Vehicle for β-Glucuronidase Delivery in the Brain by Serguera, Che, Sarkis, Chamsy, Ridet, Jean-Luc, Colin, Philippe, Moullier, Philippe, Mallet, Jacques

“…Astrocytes are a good candidate cell type for brain transplantation: They are endogenous to the CNS, they have efficient secretory machinery, and they play a…”
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Efficient myelin repair in the macaque spinal cord by autologous grafts of Schwann cells by Bachelin, Corinne, Lachapelle, François, Girard, Christelle, Moissonnier, Pierre, Serguera-Lagache, Che, Mallet, Jacques, Fontaine, Denys, Chojnowski, Alexandre, Le Guern, Eric, Nait-Oumesmar, Brahim, Baron-Van Evercooren, Anne

“…Experimental transplantation in rodent models of CNS demyelination has led to the idea that Schwann cells may be candidates for cell therapy in human myelin…”
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Transformation of Bacillus megaterium by electroporation by MORO, A, SANCHEZ, J. C, SERGUERA, C

“…Plasmidic DNA was introduced into intact cells of Bacillus megaterium by electroporation. The procedure showed an efficiency of 10 super(3) transformants mu g…”
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