Search Results - "Sergueev, Dmitri"

H-Phosphonate Approach for Solid-Phase Synthesis of Oligodeoxyribonucleoside Boranophosphates and Their Characterization by Sergueev, Dmitri S, Shaw, Barbara Ramsay

“…Substitution of a borano (BH3 -) group for nonbridging oxygen in the phosphate backbone of DNA results in a new class of isoelectronic and isoionic DNA…”
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The chemistry and biology of KP-1461, a selective nucleoside mutagen for HIV therapy by Harris, Kevin, Sergueev, Dmitri, Reno, John

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Individual Isomers of Dinucleoside Boranophosphates as Synthons for Incorporation into Oligonucleotides: Synthesis and Configurational Assignment by Sergueeva, Zinaida A., Sergueev, Dmitri S., Ribeiro, Anthony A., Summers, Jack S., Ramsay Shaw, Barbara

“…Individual isomers of the protected boranophosphates 5a and 5b, i.e., the N6‐benzyl‐2′‐deoxy‐5′‐O‐(4,4′‐dimethoxytrityl)adenosin‐3′‐yl…”
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The effect of a single boranophosphate substitution with defined configuration on the thermal stability and conformation of a DNA duplex by Wang, Joy Xin, Sergueev, Dmitri S, Shaw, Barbara Ramsay

“…Substitution of one non-bridging oxygen in a natural phosphodiester internucleotide linkage with a borano (-BH3) group results in a chiral phosphorus center in…”
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Synthesis of dithymidine boranophosphates via stereospecific boronation of H-phosphonate diesters and assignment of their configuration by Sergueeva, Zinaida A, Sergueev, Dmitri S, Shaw, Barbara Ramsay

“…The absolute configurations of the two dithymidine boranophosphate isomers were established by chemical correlation with the H-phosphonate isomers. All…”
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RNase H Activation by Stereoregular Boranophosphate Oligonucleotide by Wang, Xin, Dobrikov, Mikhail, Sergueev, Dmitri, Ramsay Shaw, Barbara

“…A stereoregular all-(S p )-boranophosphate oligodeoxyribonucleotide (BH 3 − -ODN) 15-mer was synthesized using an enzymatic approach. The BH 3 − -ODN formed a…”
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Reading, Writing, and Modulating Genetic Information with Boranophosphate Mimics of Nucleotides, DNA, and RNA by SHAW, BARBARA RAMSAY, DOBRIKOV, MIKHAIL, WANG, XIN, WAN, JING, HE, KAIZHANG, LIN, JIN-LAI, LI, PING, RAIT, VLADIMIR, SERGUEEVA, ZINAIDA A., SERGUEEV, DMITRI

“…: The P‐boranophosphates are efficient and near perfect mimics of natural nucleic acids in permitting reading and writing of genetic information with high…”
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Boranophosphate backbone: a mimic of phosphodiesters, phosphorothioates, and methyl phosphonates by Shaw, B R, Sergueev, D, He, K, Porter, K, Summers, J, Sergueeva, Z, Rait, V

“…Nucleoside boranophosphates are distinctive in that one of the non-bridging oxygens in the phosphate diester 1 is replaced by a borane moiety (BH3). Although…”
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THE EFFECT OF A SINGLE BORANOPHOSPHATE SUBSTITUTION WITH DEFINED CONFIGURATION ON THE THERMAL STABILTIY AND CONFORMATION OF A DNA DUPLEX by Wang, Joy Xin, Sergueev, Dmitri S., Shaw, Barbara Ramsay

“…Substitution of one non-bridging oxygen in a natural phosphodiester internucleotide linkage with a borano (-BH3) group results in a chiral phosphorus center in…”
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In vitro transport and delivery of antisense oligonucleotides by Hughes, J, Astriab, A, Yoo, H, Alahari, S, Liang, E, Sergueev, D, Shaw, B R, Juliano, R L

“…A variety of techniques are currently available to enhance the cellular uptake and pharmacological effectiveness of antisense oligonucleotides in the in vitro…”
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BORANE-AMINE COMPLEXES - VERSATILE REAGENTS IN THE CHEMISTRY OF NUCLEIC ACIDS AND THEIR ANALOGS by Sergueeva, Zinaida A., Sergueev, Dmitri S., Shaw, Barbara Ramsay

“…A new method for synthesis of N-alkylated nucleosides was developed. Exceptionally mild and selective conversion of N-acyl to the corresponding N-alkyl…”
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Synthesis of diuridine 3′,5′-boranophosphate: H-phosphonate approach by He, Kaizhang, Sergueev, Dmitri S., Sergueeva, Zinaida A., Shaw, Barbara Ramsay

“…Diuriine 3′,5′-boranophosphate, the RNA analogue of boranophosphate nucleic acids, was synthesized by a new approach via the H-phosphonate. Two diastereomers…”
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Rapid and Selective Reduction of Amide Group by Borane-Amine Complexes in Acyl Protected Nucleosides by Sergueeva, Zinaida A., Sergueev, Dmitri S., Shaw, Barbara Ramsay

“…Borane-amine complexes provide an unusually fast and selective reduction of a deoxynucleoside N-acyl group to a corresponding N-alkyl group. Three different…”
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SYNTHESIS OF OLIGONUCLEOSIDE BORANOPHOSPHATES VIA AN H-PHOSPHONATE METHOD WITHOUT NUCLEOBASE PROTECTION by Sergueev, Dmitri S., Sergueeva, Zinaida A., Shaw, Barbara Ramsay

“…Short oligonucleoside boranophosphates containing all four nucleosides were synthesized on solid support using base-unprotected nucleoside H-phosphonate…”
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Boranophosphate nucleic acids--a versatile DNA backbone by Rait, V, Sergueev, D, Summers, J, He, K, Huang, F, Krzyzanowska, B, Shaw, B R

“…Important chemical and biochemical properties of boranophosphate DNA and RNA oligonucleotides are reviewed. Stereoregular boranophosphate oligomers can be…”
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