Search Results - "Sergio, Masetto"

Precision medicine: a new era for inner ear diseases by Tavazzani, Elisa, Spaiardi, Paolo, Contini, Donatella, Sancini, Giulio, Russo, Giancarlo, Masetto, Sergio

“…The inner ear is the organ responsible for hearing and balance. Inner ear dysfunction can be the result of infection, trauma, ototoxic drugs, genetic mutation…”
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Corrigendum: Precision medicine: a new era for inner ear diseases by Tavazzani, Elisa, Spaiardi, Paolo, Contini, Donatella, Sancini, Giulio, Russo, Giancarlo, Masetto, Sergio

“…[This corrects the article DOI: 10.3389/fphar.2024.1328460.]…”
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Signal transmission in mature mammalian vestibular hair cells by Spaiardi, Paolo, Marcotti, Walter, Masetto, Sergio, Johnson, Stuart L.

“…The maintenance of balance and gaze relies on the faithful and rapid signaling of head movements to the brain. In mammals, vestibular organs contain two types…”
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Position-dependent patterning of spontaneous action potentials in immature cochlear inner hair cells by Kros, Corné J, Marcotti, Walter, Johnson, Stuart L, Eckrich, Tobias, Kuhn, Stephanie, Zampini, Valeria, Franz, Christoph, Ranatunga, Kishani M, Roberts, Terri P, Masetto, Sergio, Knipper, Marlies

“…Johnson and colleagues investigate spiking activity in developing inner hair cells (IHCs), showing that apical IHCs fire spontaneous action potentials in a…”
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Pimozide Increases a Delayed Rectifier K + Conductance in Chicken Embryo Vestibular Hair Cells by Giunta, Roberta, Cheli, Giulia, Spaiardi, Paolo, Russo, Giancarlo, Masetto, Sergio

“…Pimozide is a conventional antipsychotic drug largely used in the therapy for schizophrenia and Tourette's syndrome. Pimozide is assumed to inhibit synaptic…”
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Current Response in CaV1.3–/– Mouse Vestibular and Cochlear Hair Cells by Manca, Marco, Yen, Piece, Spaiardi, Paolo, Russo, Giancarlo, Giunta, Roberta, Johnson, Stuart L., Marcotti, Walter, Masetto, Sergio

“…Signal transmission by sensory auditory and vestibular hair cells relies upon Ca 2+ -dependent exocytosis of glutamate. The Ca 2+ current in mammalian inner…”
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Eps8 regulates hair bundle length and functional maturation of mammalian auditory hair cells by Zampini, Valeria, Rüttiger, Lukas, Johnson, Stuart L, Franz, Christoph, Furness, David N, Waldhaus, Jörg, Xiong, Hao, Hackney, Carole M, Holley, Matthew C, Offenhauser, Nina, Di Fiore, Pier Paolo, Knipper, Marlies, Masetto, Sergio, Marcotti, Walter

“…Hair cells of the mammalian cochlea are specialized for the dynamic coding of sound stimuli. The transduction of sound waves into electrical signals depends…”
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Progressive hearing loss and gradual deterioration of sensory hair bundles in the ears of mice lacking the actin-binding protein Eps8L2 by Furness, David N., Johnson, Stuart L., Manor, Uri, Rüttiger, Lukas, Tocchetti, Arianna, Offenhauser, Nina, Olt, Jennifer, Goodyear, Richard J., Vijayakumar, Sarath, Dai, Yuhai, Hackney, Carole M., Franz, Christoph, Di Fioreehi, Pier Paolo, Masetto, Sergio, Jones, Sherri M., Knipper, Marlies, Holley, Matthew C., Richardson, Guy P., Kachar, Bechara, Marcotti, Walter

“…Mechanotransduction in the mammalian auditory system depends on mechanosensitive channels in the hair bundles that project from the apical surface of the…”
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miR-96 regulates the progression of differentiation in mammalian cochlear inner and outer hair cells by Kuhn, Stephanie, Johnson, Stuart L, Furness, David N, Chen, Jing, Ingham, Neil, Hilton, Jennifer M, Steffes, Georg, Lewis, Morag A, Zampini, Valeria, Hackney, Carole M, Masetto, Sergio, Holley, Matthew C, Steel, Karen P, Marcotti, Walter

“…MicroRNAs (miRNAs) are small noncoding RNAs able to regulate a broad range of protein-coding genes involved in many biological processes. miR-96 is a sensory…”
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Distinct roles of Eps8 in the maturation of cochlear and vestibular hair cells by Elisa, Tavazzani, Paolo, Spaiardi, Valeria, Zampini, Donatella, Contini, Marco, Manca, Giancarlo, Russo, Ivo, Prigioni, Walter, Marcotti, Sergio, Masetto

“…Graphical abstract…”
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Exocytosis in mouse vestibular Type II hair cells shows a high‐order Ca2+ dependence that is independent of synaptotagmin‐4 by Spaiardi, Paolo, Marcotti, Walter, Masetto, Sergio, Johnson, Stuart L.

“…Mature hair cells transduce information over a wide range of stimulus intensities and frequencies for prolonged periods of time. The efficiency of such a…”
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Membrane Resonance in Pyramidal and GABAergic Neurons of the Mouse Perirhinal Cortex by Binini, Noemi, Talpo, Francesca, Spaiardi, Paolo, Maniezzi, Claudia, Pedrazzoli, Matteo, Raffin, Francesca, Mattiello, Niccolò, Castagno, Antonio N., Masetto, Sergio, Yanagawa, Yuchio, Dickson, Clayton T., Ramat, Stefano, Toselli, Mauro, Biella, Gerardo Rosario

“…The perirhinal cortex (PRC) is a polymodal associative region of the temporal lobe that works as a gateway between cortical areas and hippocampus. In recent…”
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Fine Tuning of CaV1.3 Ca2+ channel properties in adult inner hair cells positioned in the most sensitive region of the Gerbil Cochlea by Zampini, Valeria, Johnson, Stuart L, Franz, Christoph, Knipper, Marlies, Holley, Matthew C, Magistretti, Jacopo, Russo, Giancarlo, Marcotti, Walter, Masetto, Sergio

“…Hearing relies on faithful signal transmission by cochlear inner hair cells (IHCs) onto auditory fibres over a wide frequency and intensity range. Exocytosis…”
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Burst activity and ultrafast activation kinetics of CaV1.3 Ca2+ channels support presynaptic activity in adult gerbil hair cell ribbon synapses by Zampini, Valeria, Johnson, Stuart L., Franz, Christoph, Knipper, Marlies, Holley, Matthew C., Magistretti, Jacopo, Masetto, Sergio, Marcotti, Walter

“…Key points •  The transfer of sound information to the brain relies on the precise release of neurotransmitter from sensory inner hair cell (IHC) ribbon…”
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Calyx and dimorphic neurons of mouse Scarpa's ganglion express histamine H3 receptors by Tritto, Simona, Botta, Laura, Zampini, Valeria, Zucca, Gianpiero, Valli, Paolo, Masetto, Sergio

“…Histamine-related drugs are commonly used in the treatment of vertigo and related vestibular disorders. The site of action of these drugs however has not been…”
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Elementary properties of CaV1.3 Ca2+ channels expressed in mouse cochlear inner hair cells by Zampini, Valeria, Johnson, Stuart L, Franz, Christoph, Lawrence, Neil D, Munkner, Stefan, Engel, Jutta, Knipper, Marlies, Magistretti, Jacopo, Masetto, Sergio, Marcotti, Walter

“…Mammalian cochlear inner hair cells (IHCs) are specialized to process developmental signals during immature stages and sound stimuli in adult animals. These…”
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Histamine H1 receptors are expressed in mouse and frog semicircular canal sensory epithelia by Botta, Laura, Tritto, Simona, Perin, Paola, Laforenza, Umberto, Gastaldi, Giulia, Zampini, Valeria, Zucca, Gianpiero, Valli, Stefano, Masetto, Sergio, Valli, Paolo

“…Histamine-related drugs are commonly used in the treatment of vertigo and related vestibular disorders. Their site and mechanism of action, however, are still…”
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An allosteric gating model recapitulates the biophysical properties of IK,L expressed in mouse vestibular type I hair cells by Spaiardi, Paolo, Tavazzani, Elisa, Manca, Marco, Milesi, Veronica, Russo, Giancarlo, Prigioni, Ivo, Marcotti, Walter, Magistretti, Jacopo, Masetto, Sergio

“…Key points Vestibular type I and type II hair cells and their afferent fibres send information to the brain regarding the position and movement of the head…”
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Elementary properties of CaV1.3 Ca(2+) channels expressed in mouse cochlear inner hair cells by Zampini, Valeria, Johnson, Stuart L, Franz, Christoph, Lawrence, Neil D, Münkner, Stefan, Engel, Jutta, Knipper, Marlies, Magistretti, Jacopo, Masetto, Sergio, Marcotti, Walter

“…Mammalian cochlear inner hair cells (IHCs) are specialized to process developmental signals during immature stages and sound stimuli in adult animals. These…”
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Current Response in Ca V 1.3 -/- Mouse Vestibular and Cochlear Hair Cells by Manca, Marco, Yen, Piece, Spaiardi, Paolo, Russo, Giancarlo, Giunta, Roberta, Johnson, Stuart L, Marcotti, Walter, Masetto, Sergio

“…Signal transmission by sensory auditory and vestibular hair cells relies upon Ca -dependent exocytosis of glutamate. The Ca current in mammalian inner ear hair…”
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