Membrane remodeling and trafficking piloted by SARS-CoV-2
High-throughput clustered regularly interspaced short palindromic repeats (CRISPR) screens identified pro- and antiviral host factors.SARS-CoV-2 subverts the membrane trafficking system at multiple levels.The virus recruits host proteins to modulate membrane remodeling for replication, virus particl...
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| Published in: | Trends in cell biology Vol. 34; no. 9; pp. 785 - 800 |
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| Main Authors: | , , , , |
| Format: | Journal Article |
| Language: | English |
| Published: |
England
Elsevier Ltd
01-09-2024
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| Subjects: | |
| Online Access: | Get full text |
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| Summary: | High-throughput clustered regularly interspaced short palindromic repeats (CRISPR) screens identified pro- and antiviral host factors.SARS-CoV-2 subverts the membrane trafficking system at multiple levels.The virus recruits host proteins to modulate membrane remodeling for replication, virus particle formation, and propagation.Different SARS-CoV-2 egress routes have been proposed.
The molecular mechanisms underlying SARS-CoV-2 host cell invasion and life cycle have been studied extensively in recent years, with a primary focus on viral entry and internalization with the aim of identifying antiviral therapies. By contrast, our understanding of the molecular mechanisms involved in the later steps of the coronavirus life cycle is relatively limited. In this review, we describe what is known about the host factors and viral proteins involved in the replication, assembly, and egress phases of SARS-CoV-2, which induce significant host membrane rearrangements. We also discuss the limits of the current approaches and the knowledge gaps still to be addressed.
The molecular mechanisms underlying SARS-CoV-2 host cell invasion and life cycle have been studied extensively in recent years, with a primary focus on viral entry and internalization with the aim of identifying antiviral therapies. By contrast, our understanding of the molecular mechanisms involved in the later steps of the coronavirus life cycle is relatively limited. In this review, we describe what is known about the host factors and viral proteins involved in the replication, assembly, and egress phases of SARS-CoV-2, which induce significant host membrane rearrangements. We also discuss the limits of the current approaches and the knowledge gaps still to be addressed. |
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| Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 ObjectType-Review-3 content type line 23 |
| ISSN: | 0962-8924 1879-3088 1879-3088 |
| DOI: | 10.1016/j.tcb.2023.12.006 |