Search Results - "Sergi, Joseph A."

A Selective Phosphatase of Regenerating Liver Phosphatase Inhibitor Suppresses Tumor Cell Anchorage-Independent Growth by a Novel Mechanism Involving p130Cas Cleavage by DAOUTI, Sherif, LI, Wen-Hui, HONGJIN BIAN, REIDHAAR-OLSON, John F, BLISS, Sarah A, OLIVIER, Andree R, SERGI, Joseph A, FRY, David, DANHO, Waleed, RITLAND, Steve, FOTOUHI, Nader, HEIMBROOK, David, HONG QIAN, HUIFENG NIU, HUANG, Kuo-Sen, HOLMGREN, Janna, LEVIN, Wayne, REIK, Linda, MCGADY, Debra Lucas, GILLESPIE, Paul, PERROTTA, Agostino

“…The phosphatase of regenerating liver (PRL) family, a unique class of oncogenic phosphatases, consists of three members: PRL-1, PRL-2, and PRL-3. Aberrant…”
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Discovery and Control of Succinimide Formation and Accumulation at Aspartic Acid Residues in The Complementarity-Determining Region of a Therapeutic Monoclonal Antibody by VanAernum, Zachary L., Sergi, Joseph A., Dey, Monisha, Toner, Timothy, Kilgore, Bruce, Lay-Fortenbery, Ashley, Wang, Yi, Bian, Shengjie, Kochert, Brent A., Bothe, Jameson R., Gao, Xinliu, Richardson, Douglas, Schuessler, Hillary A.

“…Purpose Succinimide formation and isomerization alter the chemical and physical properties of aspartic acid residues in a protein. Modification of aspartic…”
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7-Phenyl-pyrido[2,3-d]pyrimidine-2,4-diamines: Novel and highly selective protein tyrosine phosphatase 1B inhibitors by Cheung, Adrian Wai-Hing, Banner, Bruce, Bose, Jolly, Kim, Kyungjin, Li, Shiming, Marcopulos, Nicholas, Orzechowski, Lucja, Sergi, Joseph A., Thakkar, Kshitij C., Wang, Bing-Bing, Yun, Weiya, Zwingelstein, Catherine, Berthel, Steven, Olivier, Andrée R.

“…High throughput screening of the Roche compound collection led to the identification of diaminopyrroloquinazoline series as a novel class of PTP1B inhibitors…”
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Identification of a novel class of orally active pyrimido[5,4-3][1,2,4]triazine-5,7-diamine-based hypoglycemic agents with protein tyrosine phosphatase inhibitory activity by Guertin, Kevin R., Setti, Lina, Qi, Lida, Dunsdon, Rachel M., Dymock, Brian W., Jones, Philip S., Overton, Hilary, Taylor, Mathew, Williams, Glyn, Sergi, Joseph A., Wang, Karen, Peng, Ying, Renzetti, Marcia, Boyce, Rogely, Falcioni, Fiorenza, Garippa, Ralph, Olivier, Andrée R.

“…A novel series of orally active pyrimido[5,4-3][1,2,4]triazine-5,7-diamine-based hypoglycemic agents have been identified. These compounds show non-selective…”
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