Search Results - "Sergey A., Fedoreyev"
-
1
Multifaceted Clinical Effects of Echinochrome
Published in Marine drugs (26-07-2021)“…The marine drug histochrome is a special natural antioxidant. The active substance of the drug is echinochrome A (Ech A,…”
Get full text
Journal Article -
2
Development of Novel Pharmaceutical Forms of the Marine Bioactive Pigment Echinochrome A Enabling Alternative Routes of Administration
Published in Marine drugs (01-04-2023)“…Echinochrome A (EchA), a marine bioactive pigment isolated from various sea urchin species, is the active agent of the clinically approved drug Histochrome …”
Get full text
Journal Article -
3
Regulation of Inflammation-Mediated Endothelial to Mesenchymal Transition with Echinochrome a for Improving Myocardial Dysfunction
Published in Marine drugs (30-11-2022)“…Endothelial-mesenchymal transition (EndMT) is a process by which endothelial cells (ECs) transition into mesenchymal cells (e.g., myofibroblasts and smooth…”
Get full text
Journal Article -
4
Antiviral and Antioxidant Properties of Echinochrome A
Published in Marine drugs (15-12-2018)“…The aim of this study was to examine the in vitro antioxidant and antiviral activities of echinochrome A and echinochrome-based antioxidant composition against…”
Get full text
Journal Article -
5
Maackia amurensis Rupr. et Maxim.: Supercritical CO2 Extraction and Mass Spectrometric Characterization of Chemical Constituents
Published in Molecules (Basel, Switzerland) (21-02-2023)“…Three types of extraction were used to obtain biologically active substances from the heartwood of M. amurensis: supercritical CO2 extraction, maceration with…”
Get full text
Journal Article -
6
Echinochrome A Treatment Alleviates Atopic Dermatitis-like Skin Lesions in NC/Nga Mice via IL-4 and IL-13 Suppression
Published in Marine drugs (01-11-2021)“…Atopic dermatitis (AD) is a chronic inflammatory skin disease in which skin barrier dysfunction leads to dryness, pruritus, and erythematous lesions. AD is…”
Get full text
Journal Article -
7
Effect of Echinochrome A on Submandibular Gland Dysfunction in Ovariectomized Rats
Published in Marine drugs (22-11-2022)“…Post-menopausal dry mouth or xerostomia is caused by reduced salivary secretion. This study aimed to investigate the efficacy of echinochrome A (Ech A) in…”
Get full text
Journal Article -
8
Echinochrome Prevents Sulfide Catabolism-Associated Chronic Heart Failure after Myocardial Infarction in Mice
Published in Marine drugs (01-01-2023)“…Abnormal sulfide catabolism, especially the accumulation of hydrogen sulfide (H S) during hypoxic or inflammatory stresses, is a major cause of redox…”
Get full text
Journal Article -
9
Isolation and Structure Determination of Echinochrome A Oxidative Degradation Products
Published in Molecules (Basel, Switzerland) (18-10-2020)“…Echinochrome A (Ech A, ) is one of the main pigments of several sea urchin species and is registered in the Russian pharmacopeia as an active drug substance…”
Get full text
Journal Article -
10
Echinochrome A Reverses Kidney Abnormality and Reduces Blood Pressure in a Rat Model of Preeclampsia
Published in Marine drugs (01-11-2022)“…We aimed to observe the effects of Echinochrome A (Ech A) on systemic changes using a rat model of preeclampsia. The results showed that an infusion of…”
Get full text
Journal Article -
11
Polyphenols from Maackia amurensis Heartwood Protect Neuronal Cells from Oxidative Stress and Prevent Herpetic Infection
Published in International journal of molecular sciences (09-04-2024)“…Here, we continued the investigation of anti-HSV-1 activity and neuroprotective potential of 14 polyphenolic compounds isolated from heartwood. We determined…”
Get full text
Journal Article -
12
Echinochrome A Treatment Alleviates Fibrosis and Inflammation in Bleomycin-Induced Scleroderma
Published in Marine drugs (23-04-2021)“…Scleroderma is an autoimmune disease caused by the abnormal regulation of extracellular matrix synthesis and is activated by non-regulated inflammatory cells…”
Get full text
Journal Article -
13
Echinochrome A Attenuates Cerebral Ischemic Injury through Regulation of Cell Survival after Middle Cerebral Artery Occlusion in Rat
Published in Marine drugs (28-08-2019)“…Of late, researchers have taken interest in alternative medicines for the treatment of brain ischemic stroke, where full recovery is rarely seen despite…”
Get full text
Journal Article -
14
Spinochrome D Attenuates Doxorubicin-Induced Cardiomyocyte Death via Improving Glutathione Metabolism and Attenuating Oxidative Stress
Published in Marine drugs (20-12-2018)“…Doxorubicin, an anthracycline from , exhibits antitumor activity against various cancers. However, doxorubicin is cardiotoxic at cumulative doses, causing…”
Get full text
Journal Article -
15
Echinochrome A Protects against Ultraviolet B-induced Photoaging by Lowering Collagen Degradation and Inflammatory Cell Infiltration in Hairless Mice
Published in Marine drugs (28-09-2021)“…Echinochrome A (Ech A, 7-ethyl-2,3,5,6,8-pentahydroxy-1,4-naphthoquinone) has been known to exhibit anti-oxidative and anti-inflammatory effects. However, no…”
Get full text
Journal Article -
16
Antiviral Potential of Sea Urchin Aminated Spinochromes against Herpes Simplex Virus Type 1
Published in Marine drugs (05-11-2020)“…Herpes simplex virus type 1 (HSV-1) is one of the most prevalent pathogens worldwide requiring the search for new candidates for the creation of antiherpetic…”
Get full text
Journal Article -
17
Spinochrome Identification and Quantification in Pacific Sea Urchin Shells, Coelomic Fluid and Eggs Using HPLC-DAD-MS
Published in Marine drugs (06-01-2021)“…The high-performance liquid chromatography method coupled with diode array and mass spectrometric detector (HPLC-DAD-MS) method for quinonoid pigment…”
Get full text
Journal Article -
18
Histochrome Attenuates Myocardial Ischemia-Reperfusion Injury by Inhibiting Ferroptosis-Induced Cardiomyocyte Death
Published in Antioxidants (15-10-2021)“…Reactive oxygen species (ROS) and intracellular iron levels are critical modulators of lipid peroxidation that trigger iron-dependent non-apoptotic ferroptosis…”
Get full text
Journal Article -
19
Echinochrome A Reduces Colitis in Mice and Induces In Vitro Generation of Regulatory Immune Cells
Published in Marine drugs (31-10-2019)“…Echinochrome A (Ech A), a natural pigment extracted from sea urchins, is the active ingredient of a marine-derived pharmaceutical called 'histochrome'. Since…”
Get full text
Journal Article -
20
Echinochrome A Prevents Diabetic Nephropathy by Inhibiting the PKC-Iota Pathway and Enhancing Renal Mitochondrial Function in db/db Mice
Published in Marine drugs (30-03-2023)“…Echinochrome A (EchA) is a natural bioproduct extracted from sea urchins, and is an active component of the clinical drug, Histochrome . EchA has antioxidant,…”
Get full text
Journal Article