Search Results - "Sergei N. Orlov"

Hemolysis is a primary ATP-release mechanism in human erythrocytes by Sikora, Jacek, Orlov, Sergei N., Furuya, Kishio, Grygorczyk, Ryszard

“…The hypothesis that regulated ATP release from red blood cells (RBCs) contributes to nitric oxide-dependent control of local blood flow has sparked much…”
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Effects of Hypoxia on Erythrocyte Membrane Properties-Implications for Intravascular Hemolysis and Purinergic Control of Blood Flow by Grygorczyk, Ryszard, Orlov, Sergei N

“…Intravascular hemolysis occurs in hereditary, acquired, and iatrogenic hemolytic conditions but it could be also a normal physiological process contributing to…”
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Salt-sensing mechanisms in blood pressure regulation and hypertension by Orlov, Sergei N, Mongin, Alexander A

“…High salt consumption contributes to the development of hypertension and is considered an independent risk factor for vascular remodeling, cardiac hypertrophy,…”
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Depth of the Steroid Core Location Determines the Mode of Na,K-ATPase Inhibition by Cardiotonic Steroids by Tverskoi, Artem M, Poluektov, Yuri M, Klimanova, Elizaveta A, Mitkevich, Vladimir A, Makarov, Alexander A, Orlov, Sergei N, Petrushanko, Irina Yu, Lopina, Olga D

“…Cardiotonic steroids (CTSs) are specific inhibitors of Na,K-ATPase (NKA). They induce diverse physiological effects and were investigated as potential drugs in…”
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The Hydrogel Nature of Mammalian Cytoplasm Contributes to Osmosensing and Extracellular pH Sensing by Fels, Johannes, Orlov, Sergei N., Grygorczyk, Ryszard

“…Cytoplasm is thought to have many hydrogel-like characteristics, including the ability to absorb large amounts of water and change volume in response to…”
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Transcriptomic changes triggered by ouabain in rat cerebellum granule cells: Role of α3- and α1-Na+,K+-ATPase-mediated signaling by Smolyaninova, Larisa V, Shiyan, Alexandra A, Kapilevich, Leonid V, Lopachev, Alexander V, Fedorova, Tatiana N, Klementieva, Tatiana S, Moskovtsev, Aleksey A, Kubatiev, Aslan A, Orlov, Sergei N

“…It was shown previously that inhibition of the ubiquitous α1 isoform of Na+,K+-ATPase by ouabain sharply affects gene expression profile via elevation of…”
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Transcriptomic Changes in Endothelial Cells Triggered by Na,K-ATPase Inhibition: A Search for Upstream Na + i /K + i Sensitive Genes by Klimanova, Elizaveta A, Sidorenko, Svetlana V, Abramicheva, Polina A, Tverskoi, Artem M, Orlov, Sergei N, Lopina, Olga D

“…Stimulus-dependent elevation of intracellular Ca affects gene expression via well-documented calmodulin-mediated signaling pathways. Recently, we found that…”
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In vitro assay for the efficacy assessment of AAV vectors expressing microdystrophin by Danilov, Kirill A., Vassilieva, Svetlana G., Polikarpova, Anna V., Starikova, Anna V., Shmidt, Anna A., Galkin, Ivan I., Tsitrina, Alexandra A., Egorova, Tatiana V., Orlov, Sergei N., Kotelevtsev, Yuri V.

“…AAV-delivered microdystrophin genes hold great promise for Duchenne muscular dystrophy (DMD) treatment. It is anticipated that the optimization of engineered…”
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Downregulation of TGF-β Receptor-2 Expression and Signaling through Inhibition of Na/K-ATPase by La, Jennifer, Reed, Eleanor, Chan, Lan, Smolyaninova, Larisa V, Akomova, Olga A, Mutlu, Gökhan M, Orlov, Sergei N, Dulin, Nickolai O

“…Transforming growth factor-beta (TGF-β) is a multi-functional cytokine implicated in the control of cell growth and differentiation. TGF-β signals through a…”
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Antifibrotic Effects of Noscapine through Activation of Prostaglandin E2 Receptors and Protein Kinase A by Kach, Jacob, Sandbo, Nathan, La, Jennifer, Denner, Darcy, Reed, Eleanor B., Akimova, Olga, Koltsova, Svetlana, Orlov, Sergei N., Dulin, Nickolai O.

“…Myofibroblast differentiation is a key process in the pathogenesis of fibrotic disease. We have shown previously that differentiation of myofibroblasts is…”
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Anti-fibrotic effects of tannic acid through regulation of a sustained TGF-beta receptor signaling by Reed, Eleanor B, Ard, Shawn, La, Jennifer, Park, Chan Young, Culligan, Laura, Fredberg, Jeffrey J, Smolyaninova, Larisa V, Orlov, Sergei N, Chen, Bohao, Guzy, Robert, Mutlu, Gökhan M, Dulin, Nickolai O

“…Pulmonary fibrosis is a progressive disease characterized by structural distortion of the lungs. Transforming growth factor-beta (TGF-beta) is a key cytokine…”
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Na,K-ATPase as a target for endogenous cardiotonic steroids: What's the evidence? by Orlov, Sergei N., Tverskoi, Artem M., Sidorenko, Svetlana V., Smolyaninova, Larisa V., Lopina, Olga D., Dulin, Nickolai O., Klimanova, Elizaveta A.

“…With an exception of few reports, the plasma concentration of ouabain and marinobufagenin, mostly studied cardiotonic steroids (CTS) assessed by immunoassay…”
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Critical role of the α1-Na+, K+-ATPase subunit in insensitivity of rodent cells to cytotoxic action of ouabain by Akimova, Olga A., Tverskoi, Artem M., Smolyaninova, Larisa V., Mongin, Alexander A., Lopina, Olga D., La, Jennifer, Dulin, Nickolai O., Orlov, Sergei N.

“…In rodents, ubiquitous α1-Na + , K + -ATPase is inhibited by ouabain and other cardiotonic steroids (CTS) at ~10 3 -fold higher concentrations than those…”
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Transcriptomic changes triggered by hypoxia: evidence for HIF-1α-independent, [Na+]i/[K+]i-mediated, excitation-transcription coupling by Koltsova, Svetlana V, Shilov, Boris, Birulina, Julia G, Akimova, Olga A, Haloui, Mounsif, Kapilevich, Leonid V, Gusakova, Svetlana V, Tremblay, Johanne, Hamet, Pavel, Orlov, Sergei N

“…This study examines the relative impact of canonical hypoxia-inducible factor-1alpha- (HIF-1α and Na+i/K+i-mediated signaling on transcriptomic changes evoked…”
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Elevation of Intracellular Na+ Contributes to Expression of Early Response Genes Triggered by Endothelial Cell Shrinkage by Shiyan, Alexandra A, Sidorenko, Svetlana V, Fedorov, Dmitry, Klimanova, Elizaveta A, Smolyaninova, Larisa V, Kapilevich, Leonid V, Grygorczyk, Ryszard, Orlov, Sergei N

“…BACKGROUND/AIMSProlonged hyperosmotic shrinkage evokes expression of osmoprotective genes via nuclear factor NFAT5-mediated pathway and activates Na+ influx…”
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Response: Hemolysis is a primary and physiologically relevant ATP release mechanism in human erythrocytes by Sikora, Jacek, Orlov, Sergei N., Furuya, Kishio, Grygorczyk, Ryszard

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NKCC1 and hypertension: a novel therapeutic target involved in the regulation of vascular tone and renal function by Orlov, Sergei N, Tremblay, Johanne, Hamet, Pavel

“…PURPOSE OF REVIEWThe present review summarizes recent advances in our understanding of the mechanisms involving the housekeeping Na,K,2Cl cotransporter (NKCC1)…”
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NKCC1 and NKCC2: The pathogenetic role of cation-chloride cotransporters in hypertension by Orlov, Sergei N., Koltsova, Svetlana V., Kapilevich, Leonid V., Gusakova, Svetlana V., Dulin, Nickolai O.

“…This review summarizes the data on the functional significance of ubiquitous (NKCC1) and renal-specific (NKCC2) isoforms of electroneutral sodium, potassium…”
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NKCC1 and hypertension: role in the regulation of vascular smooth muscle contractions and myogenic tone by Orlov, Sergei N, Koltsova, Svetlana V, Tremblay, Johanne, Baskakov, Mikhail B, Hamet, Pavel

“…High-ceiling diuretics (HCD), known potent inhibitors of housekeeping Na(+),K(+),2Cl cotransporter (NKCC1) and renal-specific NKCC2, decrease [Cl(-)](i),…”
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Swelling rather than shrinkage precedes apoptosis in serum-deprived vascular smooth muscle cells by Platonova, Alexandra, Koltsova, Svetlana V., Hamet, Pavel, Grygorczyk, Ryszard, Orlov, Sergei N.

“…Contrasting cell volume behaviours (swelling vs. shrinkage) are considered as criteria to distinguish necrosis from apoptosis. In this study, we employed a…”
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