Search Results - "Sergeant, Gerard P."

Blockade of Kv7 channels reverses the inhibitory effects of exchange protein directly activated by cAMP activation on purinergic contractions of the murine detrusor by Fong, Zhihui, Lall, Anshika, Mullins, Nicolas D., Santana, L. Fernando, Hollywood, Mark A., Thornbury, Keith D., Sergeant, Gerard P.

“…Purinergic contractions of the detrusor are reduced by cAMP, but the underlying mechanisms are unclear. We examined the effects of BK and Kv7 channel…”
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TRPV2 modulates mechanically Induced ATP Release from Human bronchial epithelial cells by Dunne, Orla M, Martin, S Lorraine, Sergeant, Gerard P, McAuley, Daniel F, O'Kane, Cecilia M, Button, Brian, McGarvey, Lorcan P, Lundy, Fionnuala T

“…Repetitive bouts of coughing expose the large airways to significant cycles of shear stress. This leads to the release of alarmins and the tussive agent…”
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TRPA1 activation in a human sensory neuronal model: relevance to cough hypersensitivity? by Clarke, Rebecca, Monaghan, Kevin, About, Imad, Griffin, Caoimhin S, Sergeant, Gerard P, El Karim, Ikhlas, McGeown, J Graham, Cosby, S Louise, Curtis, Timothy M, McGarvey, Lorcan P, Lundy, Fionnuala T

“…The cough reflex becomes hyperresponsive in acute and chronic respiratory diseases, but understanding the underlying mechanism is hampered by difficulty…”
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Effects of new-generation TMEM16A inhibitors on calcium-activated chloride currents in rabbit urethral interstitial cells of Cajal by Fedigan, Stephen, Bradley, Eamonn, Webb, Timothy, Large, Roddy J., Hollywood, Mark A., Thornbury, Keith D., McHale, Noel G., Sergeant, Gerard P.

“…Interstitial cells of Cajal (ICC) isolated from the rabbit urethra exhibit Ca 2+ -activated Cl − currents ( I ClCa ) that are important for the development of…”
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Muscarinic receptor-induced contractions of the detrusor are impaired in TRPC4 deficient mice by Griffin, Caoimhin S., Thornbury, Keith D., Hollywood, Mark A., Sergeant, Gerard P.

“…Acetylcholine contracts the bladder by binding to muscarinic M3 receptors on the detrusor, leading to Ca 2+ influx via voltage-gated Ca 2+ channels. The…”
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Muscarinic Receptor Induced Contractions of the Detrusor are Mediated by Activation of TRPC4 Channels by Griffin, Caoimhin S, Bradley, Eamonn, Dudem, Srikanth, Hollywood, Mark A, McHale, Noel G, Thornbury, Keith D, Sergeant, Gerard P

“…Purpose Muscarinic receptor mediated contractions of the detrusor rely on Ca2+ influx through voltage-gated Ca2+ channels but to our knowledge the mechanism…”
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The role of Ca2+ influx in spontaneous Ca2+ wave propagation in interstitial cells of Cajal from the rabbit urethra by Drumm, Bernard T., Large, Roddy J., Hollywood, Mark A., Thornbury, Keith D., Baker, Salah A., Harvey, Brian J., McHale, Noel G., Sergeant, Gerard P.

“…Key points Tonic contractions of rabbit urethra are associated with spontaneous electrical slow waves that are thought to originate in pacemaker cells termed…”
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Ca2+‐activated Cl− channels (TMEM16A) underlie spontaneous electrical activity in isolated mouse corpus cavernosum smooth muscle cells by Lim, Xin Rui, Drumm, Bernard T., Sergeant, Gerard P., Hollywood, Mark A., Thornbury, Keith D.

“…Penile detumescence is maintained by tonic contraction of corpus cavernosum smooth muscle cells (CCSMC), but the underlying mechanisms have not been fully…”
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Molecular mechanisms underlying the effect of the novel BK channel opener GoSlo: Involvement of the S4/S5 linker and the S6 segment by Webb, Timothy I., Kshatri, Aravind Singh, Large, Roddy J., Akande, Adebola Morayo, Roy, Subhrangsu, Sergeant, Gerard P., McHale, Noel G., Thornbury, Keith D., Hollywood, Mark A.

“…Significance Large-conductance Ca ²⁺-activated K ⁺ (BK) calcium-activated potassium channels alter the excitability of a wide variety of cells including nerves…”
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ATP Evokes Inward Currents in Corpus Cavernosum Myocytes by Doyle, Claire, Sergeant, Gerard P., Hollywood, Mark A., McHale, Noel G., Thornbury, Keith D.

“…Although adenosine triphosphate (ATP) has often been reported to relax the corpus cavernosum, this may be mediated by indirect effects, such as release of…”
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Role of mitochondria in modulation of spontaneous Ca2+ waves in freshly dispersed interstitial cells of Cajal from the rabbit urethra by Sergeant, Gerard P., Bradley, Eamonn, Thornbury, Keith D., McHale, Noel G., Hollywood, Mark A.

“…Interstitial cells of Cajal (ICC) isolated from the rabbit urethra exhibit pacemaker activity that results from spontaneous Ca 2+ waves. The purpose of this…”
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Ca2+ signalling in urethral interstitial cells of Cajal by Sergeant, Gerard P., Hollywood, M. A., McHale, N. G., Thornbury, K. D.

“…Interstitial cells of Cajal (ICC) in the urethra have been proposed as specialized pacemakers that are involved in the generation of urethral tone and…”
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TRPC4 currents have properties similar to the pacemaker current in interstitial cells of Cajal by Walker, Rebecca L, Koh, Sang Don, Sergeant, Gerard P, Sanders, Kenton M, Horowitz, Burton

“…Interstitial cells of Cajal (ICC) are the pacemaker cells responsible for the generation and propagation of electrical slow waves in phasic muscles of the…”
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Igniting Ca2+ sparks with TRPML1 by Sergeant, Gerard P., Hollywood, Mark A., Thornbury, Keith D.

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Igniting Ca 2+ sparks with TRPML1 by Sergeant, Gerard P, Hollywood, Mark A, Thornbury, Keith D

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The TMEM16A blockers benzbromarone and MONNA cause intracellular Ca2+-release in mouse bronchial smooth muscle cells by Dwivedi, Ritu, Drumm, Bernard T., Alkawadri, Tuleen, Martin, S. Lorraine, Sergeant, Gerard P., Hollywood, Mark A., Thornbury, Keith D.

“…We investigated effects of TMEM16A blockers benzbromarone, MONNA, CaCCinhA01 and Ani9 on isometric contractions in mouse bronchial rings and on intracellular…”
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House dust mite allergens induce Ca2+ signalling and alarmin responses in asthma airway epithelial cells by Ouyang, Xuan, Reihill, James A., Douglas, Lisa E.J., Dunne, Orla M., Sergeant, Gerard P., Martin, S. Lorraine

“…Type 2 inflammation in asthma develops with exposure to stimuli to include inhaled allergens from house dust mites (HDM). Features include mucus hypersecretion…”
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Modulation of fast sodium current in airway smooth muscle cells by exchange protein directly activated by cAMP by Matthews, Ruth M, Bradley, Eamonn, Hollywood, Mark A, Lundy, Fionnuala T, McGarvey, Lorcan P, Sergeant, Gerard P, Thornbury, Keith D

“…Airway smooth muscle (ASM) cells from mouse bronchus express a fast sodium current mediated by Na 1.7. We present evidence that this current is regulated by…”
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Evidence of an excitatory purinergic innervation in mouse corpus cavernosum smooth muscle by Lim, Xin Rui, Mercer, Mitchell, Harraz, Osama F, Hollywood, Mark A, Sergeant, Gerard P, Thornbury, Keith D

“…Evidence suggests that the corpus cavernosum smooth muscle (CCSM) cells of several species, including humans, express purinergic P2X receptors, but it is not…”
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LINGO1 is a regulatory subunit of large conductance, Ca2+-activated potassium channels by Dudem, Srikanth, Large, Roddy J., Kulkarni, Shruti, McClafferty, Heather, Tikhonova, Irina G., Sergeant, Gerard P., Thornbury, Keith D., Shipston, Michael J., Perrino, Brian A., Hollywood, Mark A.

“…LINGO1 is a transmembrane protein that is up-regulated in the cerebellum of patients with Parkinson’s disease (PD) and Essential Tremor (ET). Patients with…”
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