Search Results - "Serge N. Schiffmann"

Modulation of Ciliary Phosphoinositide Content Regulates Trafficking and Sonic Hedgehog Signaling Output by Chávez, Marcelo, Ena, Sabrina, Van Sande, Jacqueline, de Kerchove d’Exaerde, Alban, Schurmans, Stéphane, Schiffmann, Serge N.

“…Ciliary transport is required for ciliogenesis, signal transduction, and trafficking of receptors to the primary cilium. Mutations in inositol polyphosphate…”
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Pyramidal Neurons Derived from Human Pluripotent Stem Cells Integrate Efficiently into Mouse Brain Circuits In Vivo by Espuny-Camacho, Ira, Michelsen, Kimmo A., Gall, David, Linaro, Daniele, Hasche, Anja, Bonnefont, Jérôme, Bali, Camilia, Orduz, David, Bilheu, Angéline, Herpoel, Adèle, Lambert, Nelle, Gaspard, Nicolas, Péron, Sophie, Schiffmann, Serge N., Giugliano, Michele, Gaillard, Afsaneh, Vanderhaeghen, Pierre

“…The study of human cortical development has major implications for brain evolution and diseases but has remained elusive due to paucity of experimental models…”
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Slow-wave sleep is controlled by a subset of nucleus accumbens core neurons in mice by Oishi, Yo, Xu, Qi, Wang, Lu, Zhang, Bin-Jia, Takahashi, Koji, Takata, Yohko, Luo, Yan-Jia, Cherasse, Yoan, Schiffmann, Serge N., de Kerchove d’Exaerde, Alban, Urade, Yoshihiro, Qu, Wei-Min, Huang, Zhi-Li, Lazarus, Michael

“…Sleep control is ascribed to a two-process model, a widely accepted concept that posits homoeostatic drive and a circadian process as the major…”
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Differential regulation of motor control and response to dopaminergic drugs by D1R and D2R neurons in distinct dorsal striatum subregions by Durieux, Pierre F, Schiffmann, Serge N, de Kerchove d'Exaerde, Alban

“…The dorsal striatum is critically involved in a variety of motor behaviours, including regulation of motor activity, motor skill learning and motor response to…”
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Parvalbumin tunes spike‐timing and efferent short‐term plasticity in striatal fast spiking interneurons by Orduz, David, Bischop, Don Patrick, Schwaller, Beat, Schiffmann, Serge N., Gall, David

“…Key points •  Fast spiking interneurons (FSIs) modulate output of the striatum and are implicated in severe motor disorders. •  Selective expression of the…”
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Nanodomain Coupling at an Excitatory Cortical Synapse by Schmidt, Hartmut, Brachtendorf, Simone, Arendt, Oliver, Hallermann, Stefan, Ishiyama, Shimpei, Bornschein, Grit, Gall, David, Schiffmann, Serge N., Heckmann, Manfred, Eilers, Jens

“…The coupling distance between presynaptic Ca2+ influx and the sensor for vesicular transmitter release determines speed and reliability of synaptic…”
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An intrinsic mechanism of corticogenesis from embryonic stem cells by Passante, Lara, Espuny-Camacho, Ira, Dimidschstein, Jordane, Herpoel, Adèle, Hourez, Raphael, Schiffmann, Serge N, Vanderhaeghen, Pierre, van den Ameele, Jelle, Gaillard, Afsaneh, Naeije, Gilles, Gaspard, Nicolas, Bouschet, Tristan

“…The cerebral cortex develops through the coordinated generation of dozens of neuronal subtypes, but the mechanisms involved remain unclear. Here we show that…”
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The Effect of Serotonin Receptor 5-HT1B on Lateral Inhibition between Spiny Projection Neurons in the Mouse Striatum by Pommer, Stefan, Akamine, Yumiko, Schiffmann, Serge N., de Kerchove d'Exaerde, Alban, Wickens, Jeffery R.

“…The principal neurons of the striatum, the spiny projection neurons (SPNs), make inhibitory synaptic connections with each other via collaterals of their main…”
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Aminopyridines correct early dysfunction and delay neurodegeneration in a mouse model of spinocerebellar ataxia type 1 by Hourez, Raphael, Servais, Laurent, Orduz, David, Gall, David, Millard, Isabelle, de Kerchove d'Exaerde, Alban, Cheron, Guy, Orr, Harry T, Pandolfo, Massimo, Schiffmann, Serge N

“…The contribution of neuronal dysfunction to neurodegeneration is studied in a mouse model of spinocerebellar ataxia type 1 (SCA1) displaying impaired motor…”
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Neurons and cardiomyocytes derived from induced pluripotent stem cells as a model for mitochondrial defects in Friedreich's ataxia by Hick, Aurore, Wattenhofer-Donzé, Marie, Chintawar, Satyan, Tropel, Philippe, Simard, Jodie P, Vaucamps, Nadège, Gall, David, Lambot, Laurie, André, Cécile, Reutenauer, Laurence, Rai, Myriam, Teletin, Marius, Messaddeq, Nadia, Schiffmann, Serge N, Viville, Stéphane, Pearson, Christopher E, Pandolfo, Massimo, Puccio, Hélène

“…Friedreich's ataxia (FRDA) is a recessive neurodegenerative disorder commonly associated with hypertrophic cardiomyopathy. FRDA is due to expanded GAA repeats…”
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Early-onset Purkinje cell dysfunction underlies cerebellar ataxia in peroxisomal multifunctional protein-2 deficiency by De Munter, Stephanie, Verheijden, Simon, Vanderstuyft, Esther, Malheiro, Ana Rita, Brites, Pedro, Gall, David, Schiffmann, Serge N, Baes, Myriam

“…Abstract The cerebellar pathologies in peroxisomal diseases underscore that these organelles are required for the normal development and maintenance of the…”
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Neuronal Nogo-A negatively regulates dendritic morphology and synaptic transmission in the cerebellum by Petrinovic, Marija M., Hourez, Raphael, Aloy, Elisabeth M., Dewarrat, Gregoire, Gall, David, Weinmann, Oliver, Gaudias, Julien, Bachmann, Lukas C., Schiffmann, Serge N., Vogt, Kaspar E., Schwab, Martin E.

“…Neuronal signal integration as well as synaptic transmission and plasticity highly depend on the morphology of dendrites and their spines. Nogo-A is a membrane…”
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FACS array profiling identifies Ecto-5' nucleotidase as a striatopallidal neuron-specific gene involved in striatal-dependent learning by Ena, Sabrina L, De Backer, Jean-François, Schiffmann, Serge N, de Kerchove d'Exaerde, Alban

“…The striatopallidal (STP) and striatonigral (STN) neurons constitute the main neuronal populations of the striatum. Despite the increasing knowledge concerning…”
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Adenosine A2A receptors in the olfactory bulb suppress rapid eye movement sleep in rodents by Wang, Yi-Qun, Li, Rui, Wang, Dian-Ru, Cherasse, Yoan, Zhang, Ze, Zhang, Meng-Qi, Lavielle, Oriana, McEown, Kristopher, Schiffmann, Serge N., de Kerchove d’Exaerde, Alban, Qu, Wei-Min, Lazarus, Michael, Huang, Zhi-Li

“…Rapid eye movement (REM) sleep behavior disorder in humans is often accompanied by a reduced ability to smell and detect odors, and olfactory bulbectomized…”
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Purkinje Cell Dysfunction and Alteration of Long-Term Synaptic Plasticity in Fetal Alcohol Syndrome by Servais, Laurent, Hourez, Raphaël, Bearzatto, Bertrand, Gall, David, Schiffmann, Serge N., Cheron, Guy

“…In cerebellum and other brain regions, neuronal cell death because of ethanol consumption by the mother is thought to be the leading cause of neurological…”
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Grafting Neural Precursor Cells Promotes Functional Recovery in an SCA1 Mouse Model by Chintawar, Satyan, Hourez, Raphael, Ravella, Ajay, Gall, David, Orduz, David, Rai, Myriam, Bishop, Don Patrick, Geuna, Stefano, Schiffmann, Serge N, Pandolfo, Massimo

“…The B05 transgenic SCA1 mice, expressing human ataxin-1 with an expanded polyglutamine tract in cerebellar Purkinje cells (PCs), recapitulate many pathological…”
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Homeostatic plasticity of striatal neurons intrinsic excitability following dopamine depletion by Azdad, Karima, Chàvez, Marcelo, Don Bischop, Patrick, Wetzelaer, Pim, Marescau, Bart, De Deyn, Peter Paul, Gall, David, Schiffmann, Serge N

“…The striatum is the major input structure of basal ganglia and is involved in adaptive control of behaviour through the selection of relevant informations…”
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Progressive Myoclonic Epilepsy-Associated Gene KCTD7 is a Regulator of Potassium Conductance in Neurons by Azizieh, Régis, Orduz, David, Van Bogaert, Patrick, Bouschet, Tristan, Rodriguez, Wendy, Schiffmann, Serge N., Pirson, Isabelle, Abramowicz, Marc J.

“…The potassium channel tetramerization domain-containing protein 7 (KCTD7) was named after the structural homology of its predicted N-terminal broad complex,…”
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Dopamine-mediated striatal activity and function is enhanced in GlyRα2 knockout animals by Devoght, Jens, Comhair, Joris, Morelli, Giovanni, Rigo, Jean-Michel, D'Hooge, Rudi, Touma, Chadi, Palme, Rupert, Dewachter, Ilse, vandeVen, Martin, Harvey, Robert J., Schiffmann, Serge N., Piccart, Elisabeth, Brône, Bert

“…The glycine receptor alpha 2 (GlyRα2) is a ligand-gated ion channel which upon activation induces a chloride conductance. Here, we investigated the role of…”
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Tonically Active α2 Subunit-Containing Glycine Receptors Regulate the Excitability of Striatal Medium Spiny Neurons by Molchanova, Svetlana M, Comhair, Joris, Karadurmus, Deniz, Piccart, Elisabeth, Harvey, Robert J, Rigo, Jean-Michel, Schiffmann, Serge N, Brône, Bert, Gall, David

“…Medium spiny neurons (MSNs) of the dorsal striatum represent the first relay of cortico-striato-thalamic loop, responsible for the initiation of voluntary…”
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