Search Results - "Serge, Ahmed H"

Individual decision-making in the causal pathway to addiction: contributions and limitations of rodent models by Ahmed, Serge H.

“…The causal pathway from vulnerability to drug use and addiction involves a complex interaction between genetic, environmental, and behavioral factors. An…”
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Non-pharmacological factors that determine drug use and addiction by Ahmed, Serge H., Badiani, Aldo, Miczek, Klaus A., Müller, Christian P.

“…•Non-pharmacological factors modulate pharmacological action of addictive drugs.•Environmental conditions shape drug search and self-administration.•Social…”
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Pharmacokinetics trumps pharmacodynamics during cocaine choice: a reconciliation with the dopamine hypothesis of addiction by Canchy, Ludivine, Girardeau, Paul, Durand, Audrey, Vouillac-Mendoza, Caroline, Ahmed, Serge H

“…Cocaine is known to increase brain dopamine at supranormal levels in comparison to alternative nondrug rewards. According to the dopamine hypothesis of…”
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Intense sweetness surpasses cocaine reward by Lenoir, Magalie, Serre, Fuschia, Cantin, Lauriane, Ahmed, Serge H

“…Refined sugars (e.g., sucrose, fructose) were absent in the diet of most people until very recently in human history. Today overconsumption of diets rich in…”
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Reorganization of theta phase-locking in the orbitofrontal cortex drives cocaine choice under the influence by Guillem, Karine, Ahmed, Serge H.

“…Cortical theta oscillations of neuronal activity are a fundamental mechanism driving goal-directed behavior. We previously identified in the rat orbitofrontal…”
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Habitual Preference for the Nondrug Reward in a Drug Choice Setting by Vandaele, Youna, Guillem, Karine, Ahmed, Serge H.

“…For adaptive and efficient decision making, it must be possible to select between habitual alternative courses of actions. However, research in rodents…”
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Cocaine Addiction as a Homeostatic Reinforcement Learning Disorder by Keramati, Mehdi, Durand, Audrey, Girardeau, Paul, Gutkin, Boris, Ahmed, Serge H.

“…Drug addiction implicates both reward learning and homeostatic regulation mechanisms of the brain. This has stimulated 2 partially successful theoretical…”
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Animal Models of the Behavioral Symptoms of Substance Use Disorders by Vanderschuren, Louk J M J, Ahmed, Serge H

“…To more effectively manage substance use disorders, it is imperative to understand the neural, genetic, and psychological underpinnings of addictive behavior…”
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Risk-Prone Individuals Prefer the Wrong Options on a Rat Version of the Iowa Gambling Task by Rivalan, Marion, Ahmed, Serge H, Dellu-Hagedorn, Françoise

“…Background Decision making in complex and conflicting situations, as measured in the widely used Iowa Gambling Task (IGT), can be profoundly impaired in…”
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Neuronal representation of individual heroin choices in the orbitofrontal cortex by Guillem, Karine, Brenot, Viridiana, Durand, Audrey, Ahmed, Serge H.

“…Drug addiction is a harmful preference for drug use over and at the expense of other non‐drug‐related activities. We previously identified in the rat…”
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Sugar intake and craving during alcohol withdrawal in alcohol use disorder inpatients by Alarcon, Régis, Tiberghien, Margaux, Trouillet, Raphael, Pelletier, Stéphanie, Luquiens, Amandine, Ahmed, Serge H., Nalpas, Bertrand, Alaux‐Cantin, Stéphanie, Naassila, Mickaël, Perney, Pascal

“…To assess whether changes in sugar intake and craving occur during alcohol withdrawal in humans, we conducted a prospective, observational study in a…”
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Cocaine is low on the value ladder of rats: possible evidence for resilience to addiction by Cantin, Lauriane, Lenoir, Magalie, Augier, Eric, Vanhille, Nathalie, Dubreucq, Sarah, Serre, Fuschia, Vouillac, Caroline, Ahmed, Serge H

“…Assessing the relative value of cocaine and how it changes with chronic drug use represents a long-standing goal in addiction research. Surprisingly, recent…”
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Coordinated Recruitment of Cortical-Subcortical Circuits and Ascending Dopamine and Serotonin Neurons During Inhibitory Control of Cocaine Seeking in Rats by Navailles, Sylvia, Guillem, Karine, Vouillac-Mendoza, Caroline, Ahmed, Serge H

“…People with cocaine addiction retain some degree of prefrontal cortex (PFC) inhibitory control of cocaine craving, a brain capacity that may underlie the…”
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Probing the decision-making mechanisms underlying choice between drug and nondrug rewards in rats by Vandaele, Youna, Lenoir, Magalie, Vouillac-Mendoza, Caroline, Guillem, Karine, Ahmed, Serge H

“…Delineating the decision-making mechanisms underlying choice between drug and nondrug rewards remains a challenge. This study adopts an original approach to…”
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Trying to make sense of rodents' drug choice behavior by Ahmed, Serge H.

“…Since the first experimental hint for the existence of “an actual desire or striving for the drug” in nonhuman animals by Sidney Spragg in the late 1930s, much…”
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Sugar overconsumption during adolescence selectively alters motivation and reward function in adult rats by Vendruscolo, Leandro F, Gueye, Aliou B, Darnaudéry, Muriel, Ahmed, Serge H, Cador, Martine

“…There has been a dramatic escalation in sugar intake in the last few decades, most strikingly observed in the adolescent population. Sugar overconsumption has…”
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Validation crisis in animal models of drug addiction: Beyond non-disordered drug use toward drug addiction by Ahmed, Serge H.

“…In standard drug self-administration settings, animals have no choice than drug use. As a result, serious doubt exists about the interpretation of drug use in…”
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Neurobiological mechanisms in the transition from drug use to drug dependence by Koob, George F, Ahmed, Serge H, Boutrel, Benjamin, Chen, Scott A, Kenny, Paul J, Markou, Athina, O'Dell, Laura E, Parsons, Loren H, Sanna, Pietro Paolo

“…Drug addiction is a chronic relapsing disorder characterized by compulsive drug intake, loss of control over intake, and impairment in social and occupational…”
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Animal studies of addictive behavior by Vanderschuren, Louk J M J, Ahmed, Serge H

“…It is increasingly recognized that studying drug taking in laboratory animals does not equate to studying genuine addiction, characterized by loss of control…”
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Reinforcing properties of Pramipexole in normal and parkinsonian rats by Engeln, Michel, Ahmed, Serge H, Vouillac, Caroline, Tison, François, Bezard, Erwan, Fernagut, Pierre-Olivier

“…Abstract Striatal D2 and D3 dopamine receptors are involved in mediating the reinforcing properties of natural rewards and drugs. In Parkinson's disease, while…”
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