Search Results - "Sereno, Jose"

Configurational Variation of a Natural Compound within Its Source Species. The Unprecedented Case of Areolal in Piptothrix areolare by Arreaga-González, Héctor M, Rodríguez-García, Gabriela, del Río, Rosa E, Ferreira-Sereno, José A, García-Gutiérrez, Hugo A, Cerda-García-Rojas, Carlos M, Joseph-Nathan, Pedro, Gómez-Hurtado, Mario A

“…The exceptional case of a natural compound that shows drastic absolute configuration variations within the same species was examined. Sequential samples of…”
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Blood brain barrier dysfunction in healthy aging and dementia: Why, how, what for? by Cunha, Susana, Bicker, Joana, Sereno, José, Falcão, Amílcar, Fortuna, Ana

“…The blood brain barrier (BBB) is an indispensable structure that maintains the central nervous system (CNS) microenvironment for a correct neuronal function…”
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A whole brain longitudinal study in the YAC128 mouse model of Huntington's disease shows distinct trajectories of neurochemical, structural connectivity and volumetric changes by Petrella, Lorena I, Castelhano, João M, Ribeiro, Mario, Sereno, José V, Gonçalves, Sónia I, Laço, Mário N, Hayden, Michael R, Rego, A Cristina, Castelo-Branco, Miguel

“…Abstract Huntington's disease (HD) is a neurodegenerative disorder causing cognitive and motor impairments, evolving to death within 15-20 years after symptom…”
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A positron-emission tomography (PET)/magnetic resonance imaging (MRI) platform to track in vivo small extracellular vesicles by Banerjee, Arnab, Alves, Vitor, Rondão, Tiago, Sereno, José, Neves, Ângela, Lino, Miguel, Ribeiro, Andreia, Abrunhosa, Antero J, Ferreira, Lino S

“…Here we report a two-step surface modification methodology to radiolabel small extracellular vesicles (SEVs) with 64CuCl2 for PET/MRI imaging. The modification…”
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Neurobehavioral sex-related differences in Nf1 +/- mice: female show a "camouflaging"-type behavior by Santos, Sofia, Martins, Beatriz, Sereno, José, Martins, João, Castelo-Branco, Miguel, Gonçalves, Joana

“…Neurofibromatosis type 1 (NF1) is an inherited neurocutaneous disorder associated with neurodevelopmental disorders including autism spectrum disorder (ASD)…”
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Functional imaging and neurochemistry identify in vivo neuroprotection mechanisms counteracting excitotoxicity and neurovascular changes in the hippocampus and visual cortex of obese and type 2 diabetic animal models by Caramelo, Beatriz, Monteiro‐Alfredo, Tamaeh, Martins, João, Sereno, José, Castelhano, João, Manadas, Bruno, Castelo‐Branco, Miguel, Matafome, Paulo

“…Functional MRI (fMRI) with 1H‐MRS was combined on the hippocampus and visual cortex of animal models of obesity (high‐fat diet, HFD) and type 2 diabetes (T2D)…”
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Gd- and Eu-Loaded Iron Oxide@Silica Core–Shell Nanocomposites as Trimodal Contrast Agents for Magnetic Resonance Imaging and Optical Imaging by Pinho, Sonia L. C, Sereno, José, Abrunhosa, Antero J, Delville, Marie-Hélène, Rocha, João, Carlos, Luís D, Geraldes, Carlos F. G. C

“…Superparamagnetic maghemite core–porous silica shell nanoparticles, γ-Fe2O3@SiO2 (FS), with 50 nm diameter and a 10 nm core, impregnated with paramagnetic…”
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Methylglyoxal-induced glycation changes adipose tissue vascular architecture, flow and expansion, leading to insulin resistance by Rodrigues, Tiago, Matafome, Paulo, Sereno, José, Almeida, José, Castelhano, João, Gamas, Luís, Neves, Christian, Gonçalves, Sónia, Carvalho, Catarina, Arslanagic, Amina, Wilcken, Elinor, Fonseca, Rita, Simões, Ilda, Conde, Silvia Vilares, Castelo-Branco, Miguel, Seiça, Raquel

“…Microvascular dysfunction has been suggested to trigger adipose tissue dysfunction in obesity. This study investigates the hypothesis that glycation impairs…”
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A longitudinal multimodal in vivo molecular imaging study of the 3xTg-AD mouse model shows progressive early hippocampal and taurine loss by Chiquita, Samuel, Ribeiro, Mário, Castelhano, João, Oliveira, Francisco, Sereno, José, Batista, Marta, Abrunhosa, Antero, Rodrigues-Neves, Ana C, Carecho, Rafael, Baptista, Filipa, Gomes, Catarina, Moreira, Paula I, Ambrósio, António F, Castelo-Branco, Miguel

“…Abstract The understanding of the natural history of Alzheimer’s disease (AD) and temporal trajectories of in vivo molecular mechanisms requires longitudinal…”
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Retinal thinning of inner sub-layers is associated with cortical atrophy in a mouse model of Alzheimer's disease: a longitudinal multimodal in vivo study by Chiquita, Samuel, Campos, Elisa J, Castelhano, João, Ribeiro, Mário, Sereno, José, Moreira, Paula I, Castelo-Branco, Miguel, Ambrósio, António Francisco

“…It has been claimed that the retina can be used as a window to study brain disorders. However, concerning Alzheimer's disease (AD), it still remains…”
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Peptide-lipid nanoconstructs act site-specifically towards glioblastoma growth impairment by Basso, João, Mendes, Maria, Silva, Jessica, Sereno, José, Cova, Tânia, Oliveira, Rui, Fortuna, Ana, Castelo-Branco, Miguel, Falcão, Amílcar, Sousa, João, Pais, Alberto, Vitorino, Carla

“…[Display omitted] •Surface-bioconjugated usNLCs prompted pre-clinical glioblastoma growth inhibition.•The hierarchical modification of the usNLCs led to a…”
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Testing the excitation/inhibition imbalance hypothesis in a mouse model of the autism spectrum disorder: in vivo neurospectroscopy and molecular evidence for regional phenotypes by Gonçalves, Joana, Violante, Inês R, Sereno, José, Leitão, Ricardo A, Cai, Ying, Abrunhosa, Antero, Silva, Ana Paula, Silva, Alcino J, Castelo-Branco, Miguel

“…Excitation/inhibition (E/I) imbalance remains a widely discussed hypothesis in autism spectrum disorders (ASD). The presence of such an imbalance may…”
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Osteosarcoma‐Derived Exosomes as Potential PET Imaging Nanocarriers for Lung Metastasis by Almeida, Sara F.F., Fonseca, Alexandra, Sereno, José, Ferreira, Hugo R. S., Lapo‐Pais, Mariana, Martins‐Marques, Tânia, Rodrigues, Teresa, Oliveira, Rui C., Miranda, Catarina, Almeida, Luís P., Girão, Henrique, Falcão, Amílcar, Abrunhosa, Antero J., Gomes, Célia M.

“…Lung metastases represent the most adverse clinical factor and rank as the leading cause of osteosarcoma‐related death. Nearly 80% of patients present lung…”
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Sex-Dependent Social and Repetitive Behavior and Neurochemical Profile in Mouse Model of Autism Spectrum Disorder by Ferreira, Helena, Sousa, Ana Catarina, Sereno, José, Martins, João, Castelo-Branco, Miguel, Gonçalves, Joana

“…Autism spectrum disorder (ASD) is a neurodevelopmental condition characterized by deficits in social interaction, impaired communication, and repetitive…”
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Mitochondrial and redox modifications in early stages of Huntington's disease by Lopes, Carla, Ferreira, I. Luísa, Maranga, Carina, Beatriz, Margarida, Mota, Sandra I., Sereno, José, Castelhano, João, Abrunhosa, Antero, Oliveira, Francisco, De Rosa, Maura, Hayden, Michael, Laço, Mário N., Januário, Cristina, Castelo Branco, Miguel, Rego, A. Cristina

“…Deficits in mitochondrial function and redox deregulation have been attributed to Huntington's disease (HD), a genetic neurodegenerative disorder largely…”
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Improved Chemical and Radiochemical Synthesis of Neuropeptide Y Y2 Receptor Antagonist N-Methyl-JNJ-31020028 and Preclinical Positron Emission Tomography Studies by Fonseca, Inês C. F., Pais, Mariana Lapo, Rodrigues, Fábio M. S., Sereno, José, Castelo-Branco, Miguel, Cavadas, Cláudia, Pereira, Mariette M., Abrunhosa, Antero J.

“…Neuropeptide Y (NPY) is one of the most abundant peptides in the central nervous system of mammals and is involved in several physiological processes through…”
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Effects of Sitagliptin Treatment on Dysmetabolism, Inflammation, and Oxidative Stress in an Animal Model of Type 2 Diabetes (ZDF Rat) by Ferreira, Liliana, Teixeira-de-Lemos, Edite, Pinto, Filipa, Parada, Belmiro, Mega, Cristina, Vala, Helena, Pinto, Rui, Garrido, Patrícia, Sereno, José, Fernandes, Rosa, Santos, Paulo, Velada, Isabel, Melo, Andreia, Nunes, Sara, Teixeira, Frederico, Reis, Flávio

“…The purpose of this paper is to evaluate the chronic effect of sitagliptin on metabolic profile, inflammation, and redox status in the Zucker Diabetic Fatty…”
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Aquaporin-4 as a New Target against Methamphetamine-Induced Brain Alterations: Focus on the Neurogliovascular Unit and Motivational Behavior by Leitão, Ricardo Alexandre, Sereno, José, Castelhano, João Miguel, Gonçalves, Sónia Isabel, Coelho-Santos, Vanessa, Fontes-Ribeiro, Carlos, Castelo-Branco, Miguel, Silva, Ana Paula

“…Methamphetamine (METH) abuse/misuse is a worldwide problem, and despite extensive characterization of its neurotoxicity over the last years, many questions…”
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Response of the cerebral vasculature to systemic carbon monoxide administration—Regional differences and sexual dimorphism by Oliveira, Sara R., Castelhano, João, Sereno, José, Vieira, Helena L. A., Duarte, Carlos B., Castelo‐Branco, Miguel

“…Previous studies about the modulation of the vasculature by CO were performed exclusively in male or sexually immature animals. Understanding the sex…”
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Improved Characteristics of RANKL Immuno-PET Imaging Using Radiolabeled Antibody Fab Fragments by Dewulf, Jonatan, Hrynchak, Ivanna, Geudens, Sarah, Pintelon, Isabel, Vangestel, Christel, Sereno, José, van Dam, Peter A, Abrunhosa, Antero J, Elvas, Filipe, Van den Wyngaert, Tim

“…RANKL expression in the tumor microenvironment has been identified as a biomarker of immune suppression, negating the effect of some cancer immunotherapies…”
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