Effects of epidermal growth factor on lung maturation in fetal lambs

The ability of epidermal growth factor (EGF) to induce lung maturation was evaluated in fetal and neonatal lambs. EGF was infused (3-5 days) into one member of 10 fetal twin pairs, one member of 2 term twin pairs, and 2 singleton term lambs. All EGF-treated lambs had evidence of epithelial hyperplas...

Full description

Saved in:

Bibliographic Details
Published in:	The American journal of pathology Vol. 100; no. 3; pp. 707 - 726
Main Authors:	Sundell, HW, Gray, ME, Serenius, FS, Escobedo, MB, Stahlman, MT
Format:	Journal Article
Language:	English
Published:	United States ASIP 01-09-1980
Subjects:	Animals Bronchi - embryology Bronchi - ultrastructure Epidermal Growth Factor - pharmacology Female Fetal Organ Maturity - drug effects Lung - anatomy & histology Lung - embryology Lung - ultrastructure Organ Size - drug effects Peptides - pharmacology Pregnancy Pulmonary Alveoli - embryology Pulmonary Alveoli - ultrastructure Sheep Trachea - embryology Trachea - ultrastructure
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	The ability of epidermal growth factor (EGF) to induce lung maturation was evaluated in fetal and neonatal lambs. EGF was infused (3-5 days) into one member of 10 fetal twin pairs, one member of 2 term twin pairs, and 2 singleton term lambs. All EGF-treated lambs had evidence of epithelial hyperplasia of the conducting airways typical of the EGF effect. With the exception of the most immature pair, the lungs of treated versus control lambs were judged more mature by morphologic criteria by use of light and electron microscopy. None of the 6 premature lambs treated with EGF and allowed to breath showed evidence of hyaline membrane disease, while 3 untreated control lambs developed typical hyaline membranes when delivered by cesarean section after maternal hypotension. All untreated control animals showed more severe clinical symptoms of respiratory distress than did the EGF-treated animals.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0002-9440 1525-2191