Search Results - "Serebryany, Vladimir"

Improving the mechanical properties of pure magnesium by three-roll planetary milling by Diez, Mathilde, Kim, Hyoun-Ee, Serebryany, Vladimir, Dobatkin, Sergey, Estrin, Yuri

“…In this study three-roll planetary milling was used to trial its potential for enhancing the mechanical properties of pure magnesium. The material was…”
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Discovery of 4′-Chloromethyl-2′-deoxy-3′,5′-di‑O‑isobutyryl-2′-fluorocytidine (ALS-8176), A First-in-Class RSV Polymerase Inhibitor for Treatment of Human Respiratory Syncytial Virus Infection by Wang, Guangyi, Deval, Jerome, Hong, Jin, Dyatkina, Natalia, Prhavc, Marija, Taylor, Joshua, Fung, Amy, Jin, Zhinan, Stevens, Sarah K, Serebryany, Vladimir, Liu, Jyanwei, Zhang, Qingling, Tam, Yuen, Chanda, Sushmita M, Smith, David B, Symons, Julian A, Blatt, Lawrence M, Beigelman, Leo

“…Respiratory syncytial virus (RSV) is a leading pathogen of childhood and is associated with significant morbidity and mortality. To date, ribavirin is the only…”
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The Effect of Equal-Channel Angular Pressing on the Microstructure, the Mechanical and Corrosion Properties and the Anti-Tumor Activity of Magnesium Alloyed with Silver by Estrin, Yuri, Martynenko, Natalia, Anisimova, Natalia, Temralieva, Diana, Kiselevskiy, Mikhail, Serebryany, Vladimir, Raab, Georgy, Straumal, Boris, Wiese, Björn, Willumeit-Römer, Regine, Dobatkin, Sergey

“…The effect of equal-channel angular pressing (ECAP) on the microstructure, texture, mechanical properties, corrosion resistance and cytotoxicity of two…”
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Molecular Basis for the Selective Inhibition of Respiratory Syncytial Virus RNA Polymerase by 2'-Fluoro-4'-Chloromethyl-Cytidine Triphosphate by Deval, Jerome, Hong, Jin, Wang, Guangyi, Taylor, Josh, Smith, Lucas K, Fung, Amy, Stevens, Sarah K, Liu, Hong, Jin, Zhinan, Dyatkina, Natalia, Prhavc, Marija, Stoycheva, Antitsa D, Serebryany, Vladimir, Liu, Jyanwei, Smith, David B, Tam, Yuen, Zhang, Qingling, Moore, Martin L, Fearns, Rachel, Chanda, Sushmita M, Blatt, Lawrence M, Symons, Julian A, Beigelman, Leo

“…Respiratory syncytial virus (RSV) causes severe lower respiratory tract infections, yet no vaccines or effective therapeutics are available. ALS-8176 is a…”
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Preclinical Characteristics of the Hepatitis C Virus NS3/4A Protease Inhibitor ITMN-191 (R7227) by Seiwert, Scott D, Andrews, Steven W, Jiang, Yutong, Serebryany, Vladimir, Tan, Hua, Kossen, Karl, Rajagopalan, P T Ravi, Misialek, Shawn, Stevens, Sarah K, Stoycheva, Antitsa, Hong, Jin, Lim, Sharlene R, Qin, Xiaoli, Rieger, Robert, Condroski, Kevin R, Zhang, Hailong, Do, Mary Geck, Lemieux, Christine, Hingorani, Gary P, Hartley, Dylan P, Josey, John A, Pan, Lin, Beigelman, Leonid, Blatt, Lawrence M

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Effect of Rotary Swaging on Mechanical and Operational Properties of Zn–1%Mg and Zn–1%Mg–0.1%Ca Alloys by Martynenko, Natalia, Anisimova, Natalia, Rybalchenko, Georgy, Rybalchenko, Olga, Serebryany, Vladimir, Zheleznyi, Mark, Shinkareva, Maria, Gorbenko, Artem, Temralieva, Diana, Lukyanova, Elena, Sannikov, Andrey, Koltygin, Andrey, Kiselevskiy, Mikhail, Yusupov, Vladimir, Dobatkin, Sergey

“…A study of microstructure, phase composition, mechanical properties, corrosion processes, and biocompatibility in vitro of the Zn–1%Mg and Zn–1%Mg–0.1%Ca…”
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The Effect of Equal-Channel Angular Pressing on Microstructure, Mechanical Properties, and Biodegradation Behavior of Magnesium Alloyed with Silver and Gadolinium by Straumal, Boris, Martynenko, Natalia, Temralieva, Diana, Serebryany, Vladimir, Tabachkova, Natalia, Shchetinin, Igor, Anisimova, Natalia, Kiselevskiy, Mikhail, Kolyanova, Alexandra, Raab, Georgy, Willumeit-Römer, Regine, Dobatkin, Sergey, Estrin, Yuri

“…The effect of equal channel angular pressing (ECAP) on the microstructure, texture, mechanical properties, and corrosion resistance of the alloys Mg-6.0%Ag and…”
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Simultaneous Improvement of Strength, Ductility and Damping Capacity of Single β-Phase Mg–Li–Al–Zn Alloys by Yang, Xinhe, Jin, Yang, Wu, Ruizhi, Wang, Jiahao, Wang, Dan, Ma, Xiaochun, Hou, Legan, Serebryany, Vladimir, Tashlykova-Bushkevich, Iya I., Betsofen, Sergey Ya

“…Body-centered cubic (BCC) Mg–Li alloy can be effectively strengthened by with the addition of Al and Zn. However, adding excessive amounts result in reduced…”
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1381 Discovery of ALG-093989, a highly potent and orally bioavailable small molecule PD-L1 inhibitor for the treatment of cancers by Roose, Heleen, Rekstyte-Matiene, Kristina, Stevens, Sarah, Gupta, Kusum, Chang, Sandra, Liu, Cheng, Serebryany, Vladimir, Adame, Lillian, Le, Kha, Stoycheva, Antitsa, Blatt, Lawrence M, Beigelman, Leonid, Chanda, Sushmita, Smith, David B, Symons, Julian A, Jekle, Andreas, Wu, Tongfei

“…BackgroundPD-1/PD-L1 antibody-based therapies have demonstrated tremendous success in the treatment of a variety of cancers. However, these antibody drugs are…”
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1382 Discovery of ALG-094103, a liver-targeted and orally bioavailable small molecule PD-L1 inhibitor for the treatment of liver cancer by Roose, Heleen, Rekstyte-Matiene, Kristina, Stevens, Sarah, Gupta, Kusum, Chang, Sandra, Liu, Cheng, Serebryany, Vladimir, Adame, Lillian, Le, Kha, Stoycheva, Antitsa, Blatt, Lawrence M, Beigelman, Leonid, Chanda, Sushmita, Smith, David B, Symons, Julian A, Jekle, Andreas, Wu, Tongfei

“…BackgroundPD-1/PD-L1 antibody-based therapies have demonstrated success in the treatment of liver cancers. Most systemic immune-related adverse events (irAEs)…”
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An efficient preparation of protected ribonucleosides for phosphoramidite RNA synthesis by Serebryany, Vladimir, Beigelman, Leonid

“…An efficient synthesis of protected ribonucleosides useful for phosphoramidite RNA synthesis is described. Di- t-butylsilylene group was employed for…”
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Tailoring Microstructure and Properties of Fine Grained Magnesium Alloys by Severe Plastic Deformation by Vinogradov, Alexei, Serebryany, Vladimir N., Dobatkin, Sergey V.

“…Modern wrought magnesium alloys have poor formability at room temperature, which impedes the wider uptake of these alloys by the industry. Over the last…”
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Effect of Rotary Swaging on Microstructure, Texture, and Mechanical Properties of a Mg‐Al‐Zn Alloy by Estrin, Yuri, Martynenko, Natalia, Lukyanova, Elena, Serebryany, Vladimir, Gorshenkov, Mikhail, Morozov, Mikhail, Yusupov, Vladimir, Dobatkin, Sergey

“…The effect of rotary swaging on the microstructure, texture, and mechanical properties of the magnesium alloy Mg‐4.4Al‐0.9Zn‐0.4Mn is studied. Repetitive…”
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Influence of alloying with hafnium on the microstructure, texture, and properties of Cu–Cr alloy after equal channel angular pressing by Shangina, Daria, Maksimenkova, Yulia, Bochvar, Natalia, Serebryany, Vladimir, Raab, Georgy, Vinogradov, Alexei, Skrotzki, Werner, Dobatkin, Sergey

“…Equal channel angular pressing (ECAP) results in grain refinement of the Cu–0.7 % Cr alloy with an average grain size of 320 ± 73 nm. Addition of hafnium leads…”
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ALG-097111, a potent and selective SARS-CoV-2 3-chymotrypsin-like cysteine protease inhibitor exhibits in vivo efficacy in a Syrian Hamster model by Vandyck, Koen, Abdelnabi, Rana, Gupta, Kusum, Jochmans, Dirk, Jekle, Andreas, Deval, Jerome, Misner, Dinah, Bardiot, Dorothée, Foo, Caroline S., Liu, Cheng, Ren, Suping, Beigelman, Leonid, Blatt, Lawrence M., Boland, Sandro, Vangeel, Laura, Dejonghe, Steven, Chaltin, Patrick, Marchand, Arnaud, Serebryany, Vladimir, Stoycheva, Antitsa, Chanda, Sushmita, Symons, Julian A., Raboisson, Pierre, Neyts, Johan

“…There is an urgent need for antivirals targeting the SARS-CoV-2 virus to fight the current COVID-19 pandemic. The SARS-CoV-2 main protease (3CLpro) represents…”
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Synthesis and Anti-HCV Activities of 4′-Fluoro-2′-Substituted Uridine Triphosphates and Nucleotide Prodrugs: Discovery of 4′-Fluoro-2′‑C‑methyluridine 5′-Phosphoramidate Prodrug (AL-335) for the Treatment of Hepatitis C Infection by Wang, Guangyi, Dyatkina, Natalia, Prhavc, Marija, Williams, Caroline, Serebryany, Vladimir, Hu, Yujian, Huang, Yongfei, Wan, Jinqiao, Wu, Xiangyang, Deval, Jerome, Fung, Amy, Jin, Zhinan, Tan, Hua, Shaw, Kenneth, Kang, Hyunsoon, Zhang, Qingling, Tam, Yuen, Stoycheva, Antitsa, Jekle, Andreas, Smith, David B, Beigelman, Leonid

“…We report the synthesis and biological evaluation of a series of 4′-fluoro-2′-C-substituted uridines. Triphosphates of the uridine analogues exhibited a potent…”
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Discovery and Preclinical Profile of ALG-055009, a Potent and Selective Thyroid Hormone Receptor Beta (THR-β) Agonist for the Treatment of MASH by Vandyck, Koen, McGowan, David C, Luong, Xuan G, Stevens, Sarah K, Jekle, Andreas, Gupta, Kusum, Misner, Dinah L, Chanda, Sushmita, Serebryany, Vladimir, Welch, Michael, Hu, Haiyang, Lv, Zhidan, Williams, Caroline, Maskos, Klaus, Lammens, Alfred, Stoycheva, Antitsa D, Lin, Tse-I, Blatt, Lawrence M, Beigelman, Leonid N, Symons, Julian A, Raboisson, Pierre, Deval, Jerome

“…Agonists of thyroid hormone receptor β (THR-β) decreased LDL cholesterol (LDL-C) and triglyceride (TG) levels in human clinical trials for patients with…”
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Synthesis and Anti-HCV Activity of Sugar-Modified Guanosine Analogues: Discovery of AL-611 as an HCV NS5B Polymerase Inhibitor for the Treatment of Chronic Hepatitis C by Wang, Guangyi, Dyatkina, Natalia, Prhavc, Marija, Williams, Caroline, Serebryany, Vladimir, Hu, Yujian, Huang, Yongfei, Wu, Xiangyang, Chen, Tongqian, Huang, Wensheng, Rajwanshi, Vivek K, Deval, Jerome, Fung, Amy, Jin, Zhinan, Stoycheva, Antitsa, Shaw, Kenneth, Gupta, Kusum, Tam, Yuen, Jekle, Andreas, Smith, David B, Beigelman, Leonid

“…Chronic hepatitis C (CHC) is a major liver disease caused by the hepatitis C virus. The current standard of care for CHC can achieve cure rates above 95%;…”
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ALG-000184, a prodrug of capsid assembly modulator ALG-001075, demonstrates best-in-class preclinical characteristics for the treatment of chronic hepatitis B by Zhang, Qingling, Vendeville, Sandrine, Serebryany, Vladimir, Welch, Michael, Liu, Jyanwei, Williams, Caroline, Debing, Yannick, Jekle, Andreas, Stevens, Sarah, Deval, Jerome, Lin, Tse-I, Misner, Dinah, Chanda, Sushmita, Schinazi, Raymond F, Raboisson, Pierre, Symons, Julian, Blatt, Lawrence, Beigelman, Leonid, Smith, David

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SAT455 - ALG-000184, a prodrug of capsid assembly modulator ALG-001075, demonstrates best-in-class preclinical characteristics for the treatment of chronic hepatitis B by Zhang, Qingling, Vendeville, Sandrine, Serebryany, Vladimir, Welch, Michael, Liu, Jyanwei, Williams, Caroline, Debing, Yannick, Jekle, Andreas, Stevens, Sarah, Deval, Jerome, Lin, Tse-I, Misner, Dinah, Chanda, Sushmita, Schinazi, Raymond F, Raboisson, Pierre, Symons, Julian, Blatt, Lawrence, Beigelman, Leonid, Smith, David

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