The effect of insulin resistance and obesity on low-density lipoprotein particle size in children

The effect of insulin resistance and obesity on low-density lipoprotein particle size in children

In adults, it was shown that obesity and insulin resistance affect low-density lipoprotein (LDL) particle size and small dense (sd) LDL is associated with cardiovascular diseases. In this study, we investigated the effect of obesity and insulin resistance on LDL particle size. Twenty-six obese child...

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Bibliographic Details
Published in:Journal of clinical research in pediatric endocrinology Vol. 2; no. 2; pp. 63 - 66
Main Authors: Taşcılar, Mehmet Emre, Özgen, Tolga, Cihan, Murat, Abacı, Ayhan, Yeşilkaya, Ediz, Eker, Ibrahim, Serdar, Muhiddin
Format: Journal Article
Language:English
Published: Turkey Galenos Publishing 11-06-2010
Subjects:
Adolescent
Body Mass Index
Child
Child, Preschool
Cholesterol - blood
Female
Humans
Insulin Resistance
Lipoproteins, HDL - blood
Lipoproteins, LDL - blood
Lipoproteins, LDL - chemistry
Lipoproteins, VLDL - blood
Male
Obesity - blood
Obesity - physiopathology
Original
Particle Size
Triglycerides - blood
Low−density lipoprotein particle size
insulin resistance
obesity
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Summary:In adults, it was shown that obesity and insulin resistance affect low-density lipoprotein (LDL) particle size and small dense (sd) LDL is associated with cardiovascular diseases. In this study, we investigated the effect of obesity and insulin resistance on LDL particle size. Twenty-six obese children (13 girls, 13 boys) with a median age of 10.5 years and 27 healthy control subjects (17 girls, 10 boys) with a median age of 11.5 were enrolled in the study. The number of patients with insulin resistance in the obese group was 15 out of 26. In the control group, there was no subject with insulin resistance. Serum triglyceride and very LDL (VLDL) levels were higher and serum high-density lipoprotein levels (HDL) were lower in the obese patients than in the controls. There was no statistical difference in the LDL particle size between the two groups (medians: 26.6 vs. 26.7 nm (p=0.575)). The size of LDL particle was not correlated with body mass index (BMI) standard deviation score (SDS), homeostasis model assessment of insulin resistance (HOMA-IR), or serum lipids. Measurement of LDL particle size as a routine procedure is not necessary in childhood obesity.
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ISSN:1308-5727
1308-5735
DOI:10.4274/jcrpe.v2i2.63