Search Results - "Serag, I"

Recyclization of morpholinochromonylidene-thiazolidinone using nucleophiles: facile synthesis, cytotoxic evaluation, apoptosis, cell cycle and molecular docking studies of a novel series of azole, azine, azepine and pyran derivatives by Ali, Tarik E, Assiri, Mohammed A, Alqahtani, Maha N, Shati, Ali. A, Alfaifi, Mohammad. Y, Elbehairi, Serag. E. I

“…A convenient synthetic approach for construction of a novel series of substituted azoles, azines, azepines and pyrans clubbed with a morpholinothiazolidinone…”
Get full text

Synthesis, In Vitro Antimicrobial and Cytotoxic Activities of Some New Pyrazolo[1,5- a ]pyrimidine Derivatives by Fouda, Ahmed M, Abbas, Hebat-Allah S, Ahmed, Eman H, Shati, Ali A, Alfaifi, Mohammad Y, Elbehairi, Serag Eldin I

“…A new series of pyrazole ⁻ and pyrazolo[1,5- ]pyrimidine ⁻ were synthesized by using a simple, efficient procedure, and screened for their in-vitro…”
Get full text

Design, synthesis, and anticancer evaluation of novel coumarin/thiazole congeners as potential CDK2 inhibitors with molecular dynamics by Bondock, Samir, Alabbad, Nada, Hossan, Aisha, Abdou, Moaz M, Shati, Ali A, Alfaifi, Mohammad Y, Elbehairi, Serag E. I, Mohamed, Nada M

“…A series of novel coumarin-thiazoles was designed and synthesized as a possible CDK2 inhibitor with anticancer activity with low toxicity. The design relied on…”
Get full text

In Silico Computational Studies of Bioactive Secondary Metabolites from Wedelia trilobata against Anti-Apoptotic B-Cell Lymphoma-2 (Bcl-2) Protein Associated with Cancer Cell Survival and Resistance by Gowtham, Hittanahallikoppal Gajendramurthy, Ahmed, Faiyaz, Anandan, Satish, Shivakumara, C S, Bilagi, Ashween, Pradeep, Sushma, Shivamallu, Chandan, Shati, Ali A, Alfaifi, Mohammad Y, Elbehairi, Serag Eldin I, Achar, Raghu Ram, Silina, Ekaterina, Stupin, Victor, Murali, Mahadevamurthy, Kollur, Shiva Prasad

“…In the present study, the binding affinity of 52 bioactive secondary metabolites from towards the anti-apoptotic B-cell lymphoma-2 (Bcl-2) protein (PDB: 2W3L)…”
Get full text

L-Glutaminase Synthesis by Marine Halomonas meridiana Isolated from the Red Sea and Its Efficiency against Colorectal Cancer Cell Lines by Mostafa, Yasser S, Alamri, Saad A, Alfaifi, Mohammad Y, Alrumman, Sulaiman A, Elbehairi, Serag Eldin I, Taha, Tarek H, Hashem, Mohamed

“…L-glutaminase is an important anticancer agent that is used extensively worldwide by depriving cancer cells of L-glutamine. The marine bacterium, was isolated…”
Get full text

Cell Cycle Arrest and Apoptosis-Inducing Ability of Benzimidazole Derivatives: Design, Synthesis, Docking, and Biological Evaluation by Nazreen, Syed, Almalki, Abdulraheem S. A, Elbehairi, Serag Eldin I, Shati, Ali A, Alfaifi, Mohammad Y, Elhenawy, Ahmed A, Alsenani, Nawaf I, Alfarsi, Anas, Alhadhrami, Abdulrahman, Alqurashi, Esam A, Alam, Mohammad Mahboob

“…In the current study, new benzimidazole-based 1,3,4-oxadiazole derivatives have been synthesized and characterized by NMR, IR, MS, and elemental analysis. The…”
Get full text

New oxadiazole and pyrazoline derivatives as anti-proliferative agents targeting EGFR-TK: design, synthesis, biological evaluation and molecular docking study by Serag, Marwa I., Tawfik, Samar S., Badr, Sahar M. I., Eisa, Hassan M.

“…Two new series of oxadiazole and pyrazoline derivatives were designed and synthesized as promising EGFR-TK inhibitors. The in vitro antiproliferative activity…”
Get full text

Secondary metabolites of Trichoderma spp. as EGFR tyrosine kinase inhibitors: Evaluation of anticancer efficacy through computational approach by Gowtham, H G, Revanasiddappa, Prasanna D, Murali, Mahadevamurthy, Singh, Sudarshana Brijesh, Abhilash, M R, Pradeep, Sushma, Shivamallu, Chandan, Achar, Raghu Ram, Silina, Ekaterina, Stupin, Victor, Manturova, Natalia, Shati, Ali A, Alfaifi, Mohammad Y, Elbehairi, Serag Eldin I, Kollur, Shiva Prasad

“…The present study explores the epidermal growth factor receptor (EGFR) tyrosine kinase inhibition efficacy of secondary metabolites in Trichoderma spp. through…”
Get full text

Naproxen Based 1,3,4-Oxadiazole Derivatives as EGFR Inhibitors: Design, Synthesis, Anticancer, and Computational Studies by Alam, Mohammad Mahboob, Nazreen, Syed, Almalki, Abdulraheem S A, Elhenawy, Ahmed A, Alsenani, Nawaf I, Elbehairi, Serag Eldin I, Malebari, Azizah M, Alfaifi, Mohammad Y, Alsharif, Meshari A, Alfaifi, Sulaiman Y M

“…A library of novel naproxen based 1,3,4-oxadiazole derivatives ( - and - ) has been synthesized and screened for cytotoxicity as EGFR inhibitors. Among the…”
Get full text

Evaluation of the Anticancer Potential of Crude, Irradiated Cerastes cerastes Snake Venom and Propolis Ethanolic Extract & Related Biological Alterations by Abdelglil, Mostafa I., Abdallah, Sanaa O., El-Desouky, Mohamed A., Alfaifi, Mohammad Y., Elbehairi, Serag Eldin I., Mohamed, Aly F.

“…We aimed to evaluate the anticancer potential of crude venom (CV), γ irradiated Certastes cerastes venom (IRRV), and propolis ethanolic extract (PEE). IRRV…”
Get full text

Flavonol Glycosides: In Vitro Inhibition of DPPIV, Aldose Reductase and Combating Oxidative Stress are Potential Mechanisms for Mediating the Antidiabetic Activity of Cleome droserifolia by Abdel Motaal, Amira, Salem, Heba H, Almaghaslah, Dalia, Alsayari, Abdulrhman, Bin Muhsinah, Abdullatif, Alfaifi, Mohammad Y, Elbehairi, Serag Eldin I, Shati, Ali A, El-Askary, Hesham

“…Diabetes is a major health problem that is associated with high risk of various complications. Medicinal plants hold great promise against diabetes. The…”
Get full text

Correction: New multifunctional hybrids as modulators of apoptosis markers and topoisomerase II in breast cancer therapy: synthesis, characterization, and in vitro and in silico studies by Alhamdi, Heba W, Alfaifi, Mohammad Y, Shati, Ali A, Elbehairi, Serag Eldin I, Er-Rajy, Mohammed, Elshaarawy, Reda F M, Hassan, Yasser A, Zakrya, Rozan

“…[This corrects the article DOI: 10.1039/D4RA04219K.]…”
Get full text

New multifunctional hybrids as modulators of apoptosis markers and topoisomerase II in breast cancer therapy: synthesis, characterization, and in vitro and in silico studies by Alhamdi, Heba W, Alfaifi, Mohammad Y, Shati, Ali A, Elbehairi, Serag Eldin I, Er-Rajy, Mohammed, Elshaarawy, Reda F M, Hassan, Yasser A, Zakrya, Rozan

“…Recently, molecular hybrids of two or more active pharmacophores have shown promise for designing and synthesizing anticancer drugs. Herein, a new…”
Get full text

Production of Terretonin N and Butyrolactone I by Thermophilic Aspergillus terreus TM8 Promoted Apoptosis and Cell Death in Human Prostate and Ovarian Cancer Cells by Ghfar, Ayman, El-Metwally, Mohammad, Shaaban, Mohamed, Gabr, Sami, Gabr, Nada, Diab, Marwa, Aqel, Ahmad, Habila, Mohamed, Al-Qahtani, Wahidah, Alfaifi, Mohammad, Elbehairi, Serag, AlJumah, Bayan

“…The anticancer activity of terretonin N (1) and butyrolactone I (2), obtained from the thermophilic fungus Aspergillus terreus TM8, was intensively studied…”
Get full text

Zinc oxide nanoparticles prepared through microbial mediated synthesis for therapeutic applications: a possible alternative for plants by Murali, Mahadevamurthy, Gowtham, H. G., Shilpa, N., Singh, S. Brijesh, Aiyaz, Mohammed, Sayyed, R. Z., Shivamallu, Chandan, Achar, Raghu Ram, Silina, Ekaterina, Stupin, Victor, Manturova, Natalia, Shati, Ali A., Alfaifi, Mohammad Y., Elbehairi, Serag Eldin I., Kollur, Shiva Prasad

“…Zinc oxide nanoparticles (ZnO-NPs) synthesized through biogenic methods have gained significant attention due to their unique properties and potential…”
Get full text

Preparation, Characterization and In Vitro Biological Activities of New Diphenylsulphone Derived Schiff Base Ligands and Their Co(II) Complexes by Gaikwad, Kundalkesha D, Ubale, Panchsheela, Khobragade, Rahul, Deodware, Sachin, Dhale, Pratibha, Asabe, Mahadev R, Ovhal, Rekha M, Singh, Pranav, Vishwanath, Prashant, Shivamallu, Chandan, Achar, Raghu Ram, Silina, Ekaterina, Stupin, Victor, Manturova, Natalia, Shati, Ali A, Alfaifi, Mohammad Y, Elbehairi, Serag Eldin I, Gaikwad, Shashikant H, Kollur, Shiva Prasad

“…The present work describes the chemical preparation of Schiff bases derived from 4,4'-diaminodiphenyl sulfone (L -L ) and their Co(II) metal complexes. The…”
Get full text

Exploration of Anti-HIV Phytocompounds against SARS-CoV-2 Main Protease: Structure-Based Screening, Molecular Simulation, ADME Analysis and Conceptual DFT Studies by Murali, Mahadevamurthy, Gowtham, Hittanahallikoppal Gajendramurthy, Shilpa, Natarajamurthy, Krishnappa, Hemanth Kumar Naguvanahalli, Ledesma, Ana E, Jain, Anisha S, Shati, Ali A, Alfaifi, Mohammad Y, Elbehairi, Serag Eldin I, Achar, Raghu Ram, Silina, Ekaterina, Stupin, Victor, Ortega-Castro, Joaquín, Frau, Juan, Flores-Holguín, Norma, Amruthesh, Kestur Nagaraj, Shivamallu, Chandan, Kollur, Shiva Prasad, Glossman-Mitnik, Daniel

“…The ever-expanding pandemic severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has gained attention as COVID-19 and caused an emergency in…”
Get full text

Novel imidazolium-thiohydantoin hybrids and their Mn() complexes for antimicrobial and anti-liver cancer applications by Ismail, Lamia A, Zakaria, R, Hassan, Eman M, Alfaifi, Mohammad Y, Shati, Ali A, Elbehairi, Serag Eldin I, El-Bindary, A. A, Elshaarawy, Reda F. M

“…We present the effective synthesis and structural characterization of three novel imidazolium-thiohydantoin ligands (IMTHs, 5a-c ) and their Mn( iii )…”
Get full text

Exploration of Type III effector Xanthomonas outer protein Q (XopQ) inhibitor from Picrasma quassioides as an antibacterial agent using chemoinformatics analysis by Revanasiddappa, Prasanna D, Gowtham, H G, G S, Chikkanna, Gangadhar, Suchithra, A, Satish, Murali, M, Shivamallu, Chandan, Achar, Raghu Ram, Silina, Ekaterina, Stupin, Victor, Manturova, Natalia, Shati, Ali A, Alfaifi, Mohammad Y, Elbehairi, Serag Eldin I, Kollur, Shiva Prasad, Amruthesh, Kestur Nagaraj

“…The present study was focused on exploring the efficient inhibitors of closed state (form) of type III effector Xanthomonas outer protein Q (XopQ) (PDB: 4P5F)…”
Get full text

Integrated approach for studying bioactive compounds from Cladosporium spp. against estrogen receptor alpha as breast cancer drug target by Anandan, Satish, Gowtham, Hittanahallikoppal Gajendramurthy, Shivakumara, C. S., Thampy, Anjana, Singh, Sudarshana Brijesh, Murali, Mahadevamurthy, Shivamallu, Chandan, Pradeep, Sushma, Shilpa, Natarajamurthy, Shati, Ali A., Alfaifi, Mohammad Y., Elbehairi, Serag Eldin I., Ortega-Castro, Joaquín, Frau, Juan, Flores-Holguín, Norma, Kollur, Shiva Prasad, Glossman-Mitnik, Daniel

“…Cladosporium spp. have been reported for their great diversity of secondary metabolites which represent as a prominent base material for verifying the…”
Get full text