Search Results - "Sepulveda, M Rosario"

Efficient In Vitro and In Vivo Anti-Inflammatory Activity of a Diamine-PEGylated Oleanolic Acid Derivative by Jannus, Fatin, Medina-O’Donnell, Marta, Neubrand, Veronika E., Marín, Milagros, Saez-Lara, Maria J., Sepulveda, M. Rosario, Rufino-Palomares, Eva E., Martinez, Antonio, Lupiañez, Jose A., Parra, Andres, Rivas, Francisco, Reyes-Zurita, Fernando J.

“…Recent evidence has shown that inflammation can contribute to all tumorigenic states. We have investigated the anti-inflammatory effects of a diamine-PEGylated…”
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Upregulation of the secretory pathway Ca2+/Mn2+‐ATPase isoform 1 in LPS‐stimulated microglia and its involvement in Mn2+‐induced Golgi fragmentation by Bhojwani‐Cabrera, Aysha M., Bautista‐García, Alicia, Neubrand, Veronika E., Membrive‐Jiménez, Francisco A., Bramini, Mattia, Martin‐Oliva, David, Cuadros, Miguel A., Marín‐Teva, José Luis, Navascués, Julio, Vangheluwe, Peter, Sepúlveda, M. Rosario

“…Microglia play an important protective role in the healthy nervous tissue, being able to react to a variety of stimuli that induce different intracellular…”
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The endoplasmic reticulum Ca2+‐ATPase SERCA2b is upregulated in activated microglia and its inhibition causes opposite effects on migration and phagocytosis by Morales‐Ropero, Juan M., Arroyo‐Urea, Sandra, Neubrand, Veronika E., Martín‐Oliva, David, Marín‐Teva, José L., Cuadros, Miguel A., Vangheluwe, Peter, Navascués, Julio, Mata, Ana M., Sepúlveda, M. Rosario

“…Activation of microglia is an early immune response to damage in the brain. Although a key role for Ca2+ as trigger of microglial activation has been…”
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Microglia and Microglia-Like Cells: Similar but Different by Cuadros, Miguel A, Sepulveda, M Rosario, Martin-Oliva, David, Marín-Teva, José L, Neubrand, Veronika E

“…Microglia are the tissue-resident macrophages of the central nervous parenchyma. In mammals, microglia are thought to originate from yolk sac precursors and…”
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Switching Roles: Beneficial Effects of Adipose Tissue-Derived Mesenchymal Stem Cells on Microglia and Their Implication in Neurodegenerative Diseases by Sánchez-Castillo, Ana Isabel, Sepúlveda, M Rosario, Marín-Teva, José Luis, Cuadros, Miguel A, Martín-Oliva, David, González-Rey, Elena, Delgado, Mario, Neubrand, Veronika E

“…Neurological disorders, including neurodegenerative diseases, are often characterized by neuroinflammation, which is largely driven by microglia, the resident…”
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Providing an in vitro depiction of microglial cells challenged with immunostimulatory extracellular vesicles of Naegleria fowleri by Retana Moreira, Lissette, Cornet-Gomez, Alberto, Sepulveda, M Rosario, Molina-Castro, Silvia, Alvarado-Ocampo, Johan, Chaves Monge, Frida, Jara Rojas, Mariana, Osuna, Antonio, Abrahams Sandí, Elizabeth

“…is the causative agent of primary amoebic meningoencephalitis, a rapid and acute infection of the central nervous system with a fatal outcome in >97% of cases…”
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Inhibition of PMCA activity by tau as a function of aging and Alzheimer's neuropathology by Berrocal, María, Corbacho, Isaac, Vázquez-Hernández, María, Ávila, Jesús, Sepúlveda, M. Rosario, Mata, Ana M.

“…Ca2+-ATPases are plasma membrane and intracellular membrane transporters that use the energy of ATP hydrolysis to pump cytosolic Ca2+ out of the cell (PMCA) or…”
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High levels of Mn2+ inhibit secretory pathway Ca2+/Mn2+-ATPase (SPCA) activity and cause Golgi fragmentation in neurons and glia by Sepúlveda, M. Rosario, Wuytack, Frank, Mata, Ana M.

“…Excess Mn2+ in humans causes a neurological disorder known as manganism, which shares symptoms with Parkinson's disease. However, the cellular mechanisms…”
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Altered Ca²⁺ dependence of synaptosomal plasma membrane Ca²⁺-ATPase in human brain affected by Alzheimer's disease by Berrocal, María, Marcos, Daniel, Sepúlveda, M. Rosario, Pérez, Mar, Ávila, Jesús, Mata, Ana M

“…High-affinity Ca²⁺ transport ATPases play a crucial role in controlling cytosolic Ca²⁺. The amyloid β-peptide (Aβ) is a neurotoxic agent found in affected…”
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Ontogeny of ATP hydrolysis and isoform expression of the Plasma Membrane Ca2+-ATPase in mouse brain by Marcos, Daniel, Sepulveda, M Rosario, Berrocal, María, Mata, Ana M

“…BACKGROUND: Plasma membrane Ca2+-ATPases (PMCAs) are high affinity Ca2+ transporters actively involved in intracellular Ca2+ homeostasis. Considering the…”
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Primary Active Ca2+ Transport Systems in Health and Disease by Chen, Jialin, Sitsel, Aljona, Benoy, Veronick, Sepúlveda, M Rosario, Vangheluwe, Peter

“…Calcium ions (Ca2+) are prominent cell signaling effectors that regulate a wide variety of cellular processes. Among the different players in Ca2+ homeostasis,…”
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Developmental distribution of plasma membrane Ca2+‐ATPase isoforms in chick cerebellum by Sepúlveda, M. Rosario, Hidalgo‐Sánchez, Matias, Marcos, Daniel, Mata, Ana M.

“…The plasma membrane Ca2+‐ATPase (PMCA) is highly expressed in the nervous system, but little information is available about its implication in neuronal…”
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New insights into the role of the endoplasmic reticulum in microglia by Neubrand, Veronika E, Sepúlveda, M Rosario

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A developmental profile of the levels of calcium pumps in chick cerebellum by Sepúlveda, M. Rosario, Hidalgo‐Sánchez, Matías, Mata, Ana M.

“…The functional expression and distribution of intracellular ATPase (sarco(endo)plasmic reticulum Ca2+‐ATPase: SERCA) and plasma membrane Ca2+‐ATPase (PMCA) was…”
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Synthesis, Optical Properties, and Antiproliferative Evaluation of NBD-Triterpene Fluorescent Probes by Medina-O’Donnell, Marta, Vega-Granados, Karina, Martinez, Antonio, Sepúlveda, M. Rosario, Molina-Bolívar, José Antonio, Álvarez de Cienfuegos, Luis, Parra, Andres, Reyes-Zurita, Fernando J., Rivas, Francisco

“…A fluorescent labeling protocol for hydroxylated natural compounds with promising antitumor properties has been used to synthesize, in yields of 72–86%, 12…”
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Editorial: Cell biology of microglia by Sepúlveda, M Rosario, Relvas, João B, Peri, Francesca, Neubrand, Veronika E

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Phospholipids and calmodulin modulate the inhibition of PMCA activity by tau by Berrocal, María, Corbacho, Isaac, Sepulveda, M. Rosario, Gutierrez-Merino, Carlos, Mata, Ana M.

“…The disruption of Ca2+ signaling in neurons, together with a failure to keep optimal intracellular Ca2+ concentrations, have been proposed as significant…”
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Calmodulin antagonizes amyloid-β peptides-mediated inhibition of brain plasma membrane Ca2+-ATPase by Berrocal, Maria, Sepulveda, M. Rosario, Vazquez-Hernandez, Maria, Mata, Ana M.

“…The synaptosomal plasma membrane Ca2+-ATPase (PMCA) plays an essential role in regulating intracellular Ca2+ concentration in brain. We have recently found…”
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Calmodulin antagonizes amyloid-β peptides-mediated inhibition of brain plasma membrane Ca(2+)-ATPase by Berrocal, Maria, Sepulveda, M Rosario, Vazquez-Hernandez, Maria, Mata, Ana M

“…The synaptosomal plasma membrane Ca(2+)-ATPase (PMCA) plays an essential role in regulating intracellular Ca(2+) concentration in brain. We have recently found…”
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Distribution of intracellular Ca2+-ATPases in the mouse retina and their involvement in light-induced cone degeneration by Martín-Oliva, David, Martín-Guerrero, Sandra M., Carrasco, M. Carmen, Neubrand, Veronika E., Martín-Estebané, María, Marín-Teva, José L., Navascués, Julio, Cuadros, Miguel A., Vangheluwe, Peter, Sepúlveda, M. Rosario

“…Calcium signalling is involved in many processes in mammalian retina, from development to mature functions and neurodegeneration. Although proteins involved in…”
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