Search Results - "Sepe, Valentina"

Hijacking SARS-CoV-2/ACE2 Receptor Interaction by Natural and Semi-synthetic Steroidal Agents Acting on Functional Pockets on the Receptor Binding Domain by Carino, Adriana, Moraca, Federica, Fiorillo, Bianca, Marchianò, Silvia, Sepe, Valentina, Biagioli, Michele, Finamore, Claudia, Bozza, Silvia, Francisci, Daniela, Distrutti, Eleonora, Catalanotti, Bruno, Zampella, Angela, Fiorucci, Stefano

“…The coronavirus disease 2019 (COVID-19) is a respiratory tract infection caused by the severe acute respiratory syndrome coronavirus (SARS)-CoV-2. In light of…”
Get full text

Development of dual GPBAR1 agonist and RORγt inverse agonist for the treatment of inflammatory bowel diseases by Biagioli, Michele, Di Giorgio, Cristina, Morretta, Elva, Bellini, Rachele, Massa, Carmen, Urbani, Ginevra, Bordoni, Martina, Marchianò, Silvia, Lachi, Ginevra, Sepe, Valentina, Monti, Maria Chiara, Distrutti, Eleonora, Zampella, Angela, Fiorucci, Stefano

“…Inflammatory bowel diseases (IBD), including Crohn's disease and ulcerative colitis, are chronic disorders characterized by dysregulated immune response and…”
Get full text

Design, Synthesis, and Biological Evaluation of Potent Dual Agonists of Nuclear and Membrane Bile Acid Receptors by D’Amore, Claudio, Di Leva, Francesco Saverio, Sepe, Valentina, Renga, Barbara, Del Gaudio, Chiara, D’Auria, Maria Valeria, Zampella, Angela, Fiorucci, Stefano, Limongelli, Vittorio

“…Bile acids exert genomic and nongenomic effects by interacting with membrane G-protein-coupled receptors, including the bile acid receptor GP-BAR1, and nuclear…”
Get full text

Impaired Itching Perception in Murine Models of Cholestasis Is Supported by Dysregulation of GPBAR1 Signaling by Cipriani, Sabrina, Renga, Barbara, D'Amore, Claudio, Simonetti, Michele, De Tursi, Antonio Angelo, Carino, Adriana, Monti, Maria Chiara, Sepe, Valentina, Zampella, Angela, Fiorucci, Stefano

“…In cholestatic syndromes, body accumulation of bile acids is thought to cause itching. However, the mechanisms supporting this effect remain elusive. Recently,…”
Get full text

Analysis of Gastric Cancer Transcriptome Allows the Identification of Histotype Specific Molecular Signatures With Prognostic Potential by Carino, Adriana, Graziosi, Luigina, Marchianò, Silvia, Biagioli, Michele, Marino, Elisabetta, Sepe, Valentina, Zampella, Angela, Distrutti, Eleonora, Donini, Annibale, Fiorucci, Stefano

“…Gastric cancer is the fifth most common malignancy but the third leading cause of cancer-associated mortality worldwide. Therapy for gastric cancer remain…”
Get full text

Insights on FXR selective modulation. Speculation on bile acid chemical space in the discovery of potent and selective agonists by Sepe, Valentina, Festa, Carmen, Renga, Barbara, Carino, Adriana, Cipriani, Sabrina, Finamore, Claudia, Masullo, Dario, del Gaudio, Federica, Monti, Maria Chiara, Fiorucci, Stefano, Zampella, Angela

“…Bile acids are the endogenous modulators of the nuclear receptor FXR and the membrane receptor GPBAR1. FXR represents a promising pharmacological target for…”
Get full text

Discovery of BAR502, as potent steroidal antagonist of leukemia inhibitory factor receptor for the treatment of pancreatic adenocarcinoma by Di Giorgio, Cristina, Bellini, Rachele, Lupia, Antonio, Massa, Carmen, Bordoni, Martina, Marchianò, Silvia, Rosselli, Rosalinda, Sepe, Valentina, Rapacciuolo, Pasquale, Moraca, Federica, Morretta, Elva, Ricci, Patrizia, Urbani, Ginevra, Monti, Maria Chiara, Biagioli, Michele, Distrutti, Eleonora, Catalanotti, Bruno, Zampella, Angela, Fiorucci, Stefano

“…The leukemia inhibitory factor (LIF), is a cytokine belonging to IL-6 family, whose overexpression correlate with poor prognosis in cancer patients, including…”
Get full text

Structure-based drug design targeting the cell membrane receptor GPBAR1: exploiting the bile acid scaffold towards selective agonism by Di Leva, Francesco Saverio, Festa, Carmen, Renga, Barbara, Sepe, Valentina, Novellino, Ettore, Fiorucci, Stefano, Zampella, Angela, Limongelli, Vittorio

“…Bile acids can regulate nutrient metabolism through the activation of the cell membrane receptor GPBAR1 and the nuclear receptor FXR. Developing an exogenous…”
Get full text

Discovery that theonellasterol a marine sponge sterol is a highly selective FXR antagonist that protects against liver injury in cholestasis by Renga, Barbara, Mencarelli, Andrea, D'Amore, Claudio, Cipriani, Sabrina, D'Auria, Maria Valeria, Sepe, Valentina, Chini, Maria Giovanna, Monti, Maria Chiara, Bifulco, Giuseppe, Zampella, Angela, Fiorucci, Stefano

“…The farnesoid-x-receptor (FXR) is a bile acid sensor expressed in the liver and gastrointestinal tract. Despite FXR ligands are under investigation for…”
Get full text

Discovery of a Potent and Orally Active Dual GPBAR1/CysLT1R Modulator for the Treatment of Metabolic Fatty Liver Disease by Fiorucci, Stefano, Rapacciuolo, Pasquale, Fiorillo, Bianca, Roselli, Rosalinda, Marchianò, Silvia, Di Giorgio, Cristina, Bordoni, Martina, Bellini, Rachele, Cassiano, Chiara, Conflitti, Paolo, Catalanotti, Bruno, Limongelli, Vittorio, Sepe, Valentina, Biagioli, Michele, Zampella, Angela

“…Nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH) are two highly prevalent human diseases caused by excessive fat deposition in…”
Get full text

The leukemia inhibitory factor regulates fibroblast growth factor receptor 4 transcription in gastric cancer by Di Giorgio, Cristina, Bellini, Rachele, Lupia, Antonio, Massa, Carmen, Urbani, Ginevra, Bordoni, Martina, Marchianò, Silvia, Rosselli, Rosalinda, De Gregorio, Rosa, Rapacciuolo, Pasquale, Sepe, Valentina, Morretta, Elva, Monti, Maria Chiara, Moraca, Federica, Cari, Luigi, Ullah, Khan Rana Sami, Natalizi, Nicola, Graziosi, Luigina, Distrutti, Eleonora, Biagioli, Michele, Catalanotti, Bruno, Donini, Annibale, Zampella, Angela, Fiorucci, Stefano

“…Purpose The gastric adenocarcinoma (GC) represents the third cause of cancer-related mortality worldwide, and available therapeutic options remain sub-optimal…”
Get full text

Introduction of Nonacidic Side Chains on 6-Ethylcholane Scaffolds in the Identification of Potent Bile Acid Receptor Agonists with Improved Pharmacokinetic Properties by Finamore, Claudia, Baronissi, Giuliana, Marchianò, Silvia, Di Leva, Francesco Saverio, Carino, Adriana, Monti, Maria Chiara, Limongelli, Vittorio, Zampella, Angela, Fiorucci, Stefano, Sepe, Valentina

“…As a cellular bile acid sensor, farnesoid X receptor (FXR) and the membrane G-coupled receptor (GPBAR1) participate in maintaining bile acid, lipid, and…”
Get full text

Natural ligands for nuclear receptors: biology and potential therapeutic applications by D'Auria, Maria Valeria, Sepe, Valentina, Zampella, Angela

“…Nuclear receptors are key regulators of various processes including reproduction, development, and metabolism of xeno- and endobiotics. Research in the last…”
Get more information

Repositioning Mifepristone as a Leukaemia Inhibitory Factor Receptor Antagonist for the Treatment of Pancreatic Adenocarcinoma by Di Giorgio, Cristina, Lupia, Antonio, Marchianò, Silvia, Bordoni, Martina, Bellini, Rachele, Massa, Carmen, Urbani, Ginevra, Roselli, Rosalinda, Moraca, Federica, Sepe, Valentina, Catalanotti, Bruno, Morretta, Elva, Monti, Maria Chiara, Biagioli, Michele, Distrutti, Eleonora, Zampella, Angela, Fiorucci, Stefano

“…Pancreatic cancer is a leading cause of cancer mortality and is projected to become the second-most common cause of cancer mortality in the next decade. While…”
Get full text

Correction to “Discovery of a Novel Class of Dual GPBAR1 Agonists–RORγt Inverse Agonists for the Treatment of IL-17-Mediated Disorders” by Fiorillo, Bianca, Roselli, Rosalinda, Finamore, Claudia, Biagioli, Michele, di Giorgio, Cristina, Bordoni, Martina, Conflitti, Paolo, Marchianò, Silvia, Bellini, Rachele, Rapacciuolo, Pasquale, Cassiano, Chiara, Limongelli, Vittorio, Sepe, Valentina, Catalanotti, Bruno, Fiorucci, Stefano, Zampella, Angela

“…[This corrects the article DOI: 10.1021/acsomega.2c07907.]…”
Get full text

Navigation in bile acid chemical space: discovery of novel FXR and GPBAR1 ligands by Finamore, Claudia, Festa, Carmen, Renga, Barbara, Sepe, Valentina, Carino, Adriana, Masullo, Dario, Biagioli, Michele, Marchianò, Silvia, Capolupo, Angela, Monti, Maria Chiara, Fiorucci, Stefano, Zampella, Angela

“…Bile acids are signaling molecules interacting with nuclear receptors and membrane G-protein-coupled receptors. Among these receptors, the farnesoid X receptor…”
Get full text

Thiazolidin-4-one-based compounds interfere with the eicosanoid biosynthesis pathways by mPGES-1/sEH/5-LO multi-target inhibition by Colarusso, Ester, Potenza, Marianna, Lauro, Gianluigi, Chini, Maria Giovanna, Sepe, Valentina, Zampella, Angela, Fischer, Katrin, Hofstetter, Robert K., Werz, Oliver, Bifulco, Giuseppe

“…Here we report the application of a multi-disciplinary protocol for investigating thiazolidin-4-one-based compounds as new promising anti-inflammatory agents…”
Get full text

Targeting Bile Acid Receptors: Discovery of a Potent and Selective Farnesoid X Receptor Agonist as a New Lead in the Pharmacological Approach to Liver Diseases by Festa, Carmen, De Marino, Simona, Carino, Adriana, Sepe, Valentina, Marchianò, Silvia, Cipriani, Sabrina, Di Leva, Francesco S, Limongelli, Vittorio, Monti, Maria C, Capolupo, Angela, Distrutti, Eleonora, Fiorucci, Stefano, Zampella, Angela

“…Bile acid (BA) receptors represent well-defined targets for the development of novel therapeutic approaches to metabolic and inflammatory diseases. In the…”
Get full text

Homophymine A, an Anti-HIV Cyclodepsipeptide from the Sponge Homophymia sp by Zampella, Angela, Sepe, Valentina, Luciano, Paolo, Bellotta, Filomena, Monti, Maria Chiara, D’Auria, Maria Valeria, Jepsen, Trine, Petek, Sylvain, Adeline, Marie-Thérèse, Laprévôte, Olivier, Aubertin, Anne-Marie, Debitus, Cécile, Poupat, Christiane, Ahond, Alain

“…A new anti-HIV cyclodepsipeptide, homophymine A, was isolated from a New Caledonian collection of the marine sponge Homophymia sp. The structure of homophymine…”
Get full text

Insights on pregnane-X-receptor modulation. Natural and semisynthetic steroids from Theonella marine sponges by Sepe, Valentina, D'Amore, Claudio, Ummarino, Raffella, Renga, Barbara, D'Auria, Maria Valeria, Novellino, Ettore, Sinisi, Annamaria, Taglialatela-Scafati, Orazio, Nakao, Yoichi, Limongelli, Vittorio, Zampella, Angela, Fiorucci, Stefano

“…Pregnane-X-receptor (PXR) is a member of nuclear receptors superfamily that activates gene transcription by binding to responsive elements in the promoter of…”
Get full text