Search Results - "Seon, Ben K"

Endoglin-targeted cancer therapy by Seon, Ben K, Haba, Akinao, Matsuno, Fumihiko, Takahashi, Norihiko, Tsujie, Masanori, She, Xinwei, Harada, Naoko, Uneda, Shima, Tsujie, Tomoko, Toi, Hirofumi, Tsai, Hilda, Haruta, Yuro

“…Vascular-targeting antiangiogenic therapy (VTAT) of cancer can be advantageous over conventional tumor cell targeted cancer therapy if an appropriate target is…”
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Anti‐endoglin monoclonal antibodies are effective for suppressing metastasis and the primary tumors by targeting tumor vasculature by Uneda, Shima, Toi, Hirofumi, Tsujie, Tomoko, Tsujie, Masanori, Harada, Naoko, Tsai, Hilda, Seon, Ben K.

“…Anti‐metastatic activity of an antitumor agent is exceedingly important because metastasis is the primary cause of death for most solid cancer patients. In…”
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Endoglin inhibitor TRC105 with or without bevacizumab for bevacizumab-refractory glioblastoma (ENDOT): a multicenter phase II trial by Ahluwalia, Manmeet S., Rogers, Lisa R., Chaudhary, Rekha, Newton, Herbert, Ozair, Ahmad, Khosla, Atulya A., Nixon, Andrew B., Adams, Bonne J., Seon, Ben K., Peereboom, David M., Theuer, Charles P.

“…Background Glioblastoma (GBM), the most lethal primary brain tumor, has limited treatment options upon recurrence after chemoradiation and bevacizumab. TRC105…”
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Identification of unique molecular heterogeneity of human CD79, the signaling component of the human B cell antigen receptor (BCR), and synergistic potentiation of the CD79-targeted therapy of B cell tumors by co-targeting of CD79a and CD79b by Seon, Ben K., Okazaki, Morihiro, Duzen, Jill, Matsuno, Fumihiko, Goey, Andrew K.L., Maguire, Orla

“…We identified unique molecular heterogeneity of CD79 of human B cell antigen receptor (BCR) that may open a new approach to the ongoing CD79b-targeted therapy…”
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A Phase I First-in-Human Study of TRC105 (Anti-Endoglin Antibody) in Patients with Advanced Cancer by ROSEN, Lee S, HURWITZ, Herbert I, THEUER, Charles P, LEIGH, Bryan R, GORDON, Michael S, WONG, Michael K, GOLDMAN, Jonathan, MENDELSON, David S, FIGG, William D, SPENCER, Shawn, ADAMS, Bonne J, ALVAREZ, Delia, SEON, Ben K

“…TRC105 is a chimeric IgG1 monoclonal antibody that binds CD105 (endoglin). This first-in-human, phase I, open-label study assessed safety, pharmacokinetics,…”
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An open-label phase Ib dose-escalation study of TRC105 (anti-endoglin antibody) with bevacizumab in patients with advanced cancer by Gordon, Michael S, Robert, Francisco, Matei, Daniela, Mendelson, David S, Goldman, Jonathan W, Chiorean, E Gabriela, Strother, Robert M, Seon, Ben K, Figg, William D, Peer, Cody J, Alvarez, Delia, Adams, Bonne J, Theuer, Charles P, Rosen, Lee S

“…Endoglin, an endothelial cell membrane receptor expressed on angiogenic tumor vessels, is essential for angiogenesis and upregulated in the setting of VEGF…”
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Facilitation of endoglin‐targeting cancer therapy by development/utilization of a novel genetically engineered mouse model expressing humanized endoglin (CD105) by Toi, Hirofumi, Tsujie, Masanori, Haruta, Yuro, Fujita, Kanako, Duzen, Jill, Seon, Ben K.

“…Endoglin (ENG) is a TGF‐β coreceptor and essential for vascular development and angiogenesis. A chimeric antihuman ENG (hENG) monoclonal antibody (mAb) c‐SN6j…”
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An Open Label Phase Ib Dose Escalation Study of TRC105 (Anti‐Endoglin Antibody) with Axitinib in Patients with Metastatic Renal Cell Carcinoma by Choueiri, Toni K., Michaelson, M. Dror, Posadas, Edwin M., Sonpavde, Guru P., McDermott, David F., Nixon, Andrew B., Liu, Yingmiao, Yuan, Zhenhua, Seon, Ben K., Walsh, Meghara, Jivani, Manoj A., Adams, Bonne J., Theuer, Charles P.

“…Background TRC105 is an IgG1 endoglin monoclonal antibody that potentiates VEGF inhibitors in preclinical models. We assessed safety, pharmacokinetics, and…”
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Anti‐tumor activity of an anti‐endoglin monoclonal antibody is enhanced in immunocompetent mice by Tsujie, Masanori, Tsujie, Tomoko, Toi, Hirofumi, Uneda, Shima, Shiozaki, Ken, Tsai, Hilda, Seon, Ben K.

“…In the present study, we investigated the mechanisms by which anti‐endoglin (EDG; CD105) monoclonal antibodies (mAbs) suppress angiogenesis and tumor growth…”
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A Phase II Clinical Trial of TRC105 (Anti-Endoglin Antibody) in Adults with Advanced/Metastatic Urothelial Carcinoma by Apolo, Andrea B, Karzai, Fatima H, Trepel, Jane B, Alarcon, Sylvia, Lee, Sunmin, Lee, Min-Jung, Tomita, Yusuke, Cao, Liang, Yu, Yunkai, Merino, Maria J, Madan, Ravi A, Parnes, Howard L, Steinberg, Seth M, Walter Rodriguez, Beatriz, Seon, Ben K, Gulley, James L, Arlen, Philip M, Dawson, Nancy A, Figg, William D, Dahut, William L

“…Abstract Background This trial assessed the efficacy and tolerability of TRC105, a chimeric monoclonal antibody that targets CD105 (endoglin) in patients with…”
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Effective anti-angiogenic therapy of established tumors in mice by naked anti-human endoglin (CD105) antibody : Differences in growth rate and therapeutic response between tumors growing at different sites by TSUJIE, Masanori, UNEDA, Shima, TSAI, Hilda, SEON, Ben K

“…We investigated anti-angiogenic/vascular targeting therapy of established tumors in immunocompetent mice using an anti-human endoglin (EDG; CD105) monoclonal…”
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Synergy between anti‐endoglin (CD105) monoclonal antibodies and TGF‐β in suppression of growth of human endothelial cells by She, Xinwei, Matsuno, Fumihiko, Harada, Naoko, Tsai, Hilda, Seon, Ben K.

“…Endoglin (CD105) is a proliferation‐associated cell membrane antigen of endothelial cells and strongly expressed in the angiogenic vasculature of solid tumors…”
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Association of serum endoglin with metastasis in patients with colorectal, breast, and other solid tumors, and suppressive effect of chemotherapy on the serum endoglin by TAKAHASHI, Norihiko, KAWANISHI-TABATA, Rika, HABA, Akinao, TABATA, Masahiro, HARUTA, Yuro, TSAI, Hilda, SEON, Ben K

“…In this report, we present data indicating that the increased serum endoglin (EDG; CD105) quantitated by a double-antibody sandwich assay is associated with…”
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Induction of Lasting Complete Regression of Preformed Distinct Solid Tumors by Targeting the Tumor Vasculature Using Two New Anti-Endoglin Monoclonal Antibodies by MATSUNO, F, HARUTA, Y, KONDO, M, TSAI, H, BARCOS, M, SEON, B. K

“…Endoglin (EDG, CD105) is a proliferation-associated antigen on endothelial cells. In this study, two new anti-EDG monoclonal antibodies (mAbs) Y4-2F1 (or…”
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Expression of endoglin (CD105) in tumor blood vessels by Seon, Ben K.

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Receptor-targeted anticancer therapy by Seon, Ben K., Haruta, Yuro, Matsuno, Fumihiko, Haba, Akinao, Takahashi, Norihiko, She, Xinwei, Harada, Naoko, Uneda, Shima, Tsujie, Masanori, Tsujie, Tomoko, Toi, Hirofumi, Tsai, Hilda

“…ENG is a homodimeric cell membrane glycoprotein that was initially found on human leukemia cells and subsequently on endothelial cells. ENG as a target for…”
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Antiangiogenic chimeric anti-endoglin (CD105) antibody : pharmacokinetics and immunogenicity in nonhuman primates and effects of doxorubicin by SHIOZAKI, Ken, HARADA, Naoko, GRECO, William R, HABA, Akinao, UNEDA, Shima, TSAI, Hilda, SEON, Ben K

“…We generated a human/mouse chimeric antibody c-SN6j of human IgG1 isotype from a murine anti-human endoglin (EDG) monoclonal antibody (mAb) SN6j that…”
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Angiogenesis and metastasis marker of human tumors by Seon, B K, Takahashi, N, Haba, A, Matsuno, F, Haruta, Y, She, X W, Harada, N, Tsai, H

“…Tumor growth and metastasis are dependent on angiogenesis. Therefore, certain angiogenesis markers may be useful as metastasis markers and/or the targets for…”
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Unique human glycoprotein, 7alpha;1-microglycoprotein: isolation from the urine of a cancer patient and its characterization by Seon, Ben K, Pressman, David

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Establishment of new SCID and nude mouse models of human B leukemia/lymphoma and effective therapy of the tumors with immunotoxin and monoclonal antibody : marked difference between the SCID and nude mouse models in the antitumor efficacy of monoclonal antibody by KAWATA, A, YOSHIDA, M, OKAZAKI, M, YOKOTA, S, BARCOS, M, SEON, B. K

“…BALL-1, a human B leukemia/lymphoma cell line, was transplanted into nude and SCID mice under various conditions. The transplantation was substantially…”
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