Search Results - "Seok Lee, Yong"

Structures of human ENT1 in complex with adenosine reuptake inhibitors by Wright, Nicholas J., Lee, Seok-Yong

“…The human equilibrative nucleoside transporter 1 (hENT1), a member of the SLC29 family, plays crucial roles in adenosine signaling, cellular uptake of…”
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Conformational plasticity in the selectivity filter of the TRPV2 ion channel by Zubcevic, Lejla, Le, Son, Yang, Huanghe, Lee, Seok-Yong

“…Transient receptor potential vanilloid (TRPV) channels are activated by ligands and heat and are involved in various physiological processes. In contrast to…”
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Structure of the cold- and menthol-sensing ion channel TRPM8 by Yin, Ying, Wu, Mengyu, Zubcevic, Lejla, Borschel, William F, Lander, Gabriel C, Lee, Seok-Yong

“…Transient receptor potential melastatin (TRPM) cation channels are polymodal sensors that are involved in a variety of physiological processes. Within the TRPM…”
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Structural basis of cooling agent and lipid sensing by the cold-activated TRPM8 channel by Yin, Ying, Le, Son C, Hsu, Allen L, Borgnia, Mario J, Yang, Huanghe, Lee, Seok-Yong

“…Transient receptor potential melastatin member 8 (TRPM8) is a calcium ion (Ca )-permeable cation channel that serves as the primary cold and menthol sensor in…”
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Conformational ensemble of the human TRPV3 ion channel by Zubcevic, Lejla, Herzik, Mark A., Wu, Mengyu, Borschel, William F., Hirschi, Marscha, Song, Albert S., Lander, Gabriel C., Lee, Seok-Yong

“…Transient receptor potential vanilloid channel 3 (TRPV3), a member of the thermosensitive TRP (thermoTRPV) channels, is activated by warm temperatures and…”
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Structural Insights into Electrophile Irritant Sensing by the Human TRPA1 Channel by Suo, Yang, Wang, Zilong, Zubcevic, Lejla, Hsu, Allen L., He, Qianru, Borgnia, Mario J., Ji, Ru-Rong, Lee, Seok-Yong

“…Transient receptor potential channel subfamily A member 1 (TRPA1) is a Ca2+-permeable cation channel that serves as one of the primary sensors of environmental…”
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GlcNAc-1-P-transferase–tunicamycin complex structure reveals basis for inhibition of N-glycosylation by Yoo, Jiho, Mashalidis, Ellene H., Kuk, Alvin C. Y., Yamamoto, Kazuki, Kaeser, Benjamin, Ichikawa, Satoshi, Lee, Seok-Yong

“…N-linked glycosylation is a predominant post-translational modification of protein in eukaryotes, and its dysregulation is the etiology of several human…”
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Toward a Molecular Basis of Cellular Nucleoside Transport in Humans by Wright, Nicholas J, Lee, Seok-Yong

“…Nucleosides play central roles in all facets of life, from metabolism to cellular signaling. Because of their physiochemical properties, nucleosides are lipid…”
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Vanilloid-dependent TRPV1 opening trajectory from cryoEM ensemble analysis by Kwon, Do Hoon, Zhang, Feng, Fedor, Justin G., Suo, Yang, Lee, Seok-Yong

“…Single particle cryo-EM often yields multiple protein conformations within a single dataset, but experimentally deducing the temporal relationship of these…”
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Cryo-EM structure of a mitochondrial calcium uniporter by Yoo, Jiho, Wu, Mengyu, Yin, Ying, Herzik, Jr, Mark A, Lander, Gabriel C, Lee, Seok-Yong

“…Calcium transport plays an important role in regulating mitochondrial physiology and pathophysiology. The mitochondrial calcium uniporter (MCU) is a…”
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Activation mechanism of the mouse cold-sensing TRPM8 channel by cooling agonist and PIP2 by Yin, Ying, Zhang, Feng, Shasha Feng, Butay, Kevin John, Borgnia, Mario J, Im, Wonpil, Seok-Yong, Lee

“…Chilly receptionThe sensation of cold stimuli in mammals is mediated by transient receptor potential melastatin 8 (TRPM8) channels that also respond to various…”
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Crystal Structure of MraY, an Essential Membrane Enzyme for Bacterial Cell Wall Synthesis by Chung, Ben C., Zhao, Jinshi, Gillespie, Robert A., Kwon, Do-Yeon, Guan, Ziqiang, Hong, Jiyong, Zhou, Pei, Lee, Seok-Yong

“…MraY (phospho-MurNAc-pentapeptide translocase) is an integral membrane enzyme that catalyzes an essential step of bacterial cell wall biosynthesis: the…”
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Lipid nanoparticles for delivery of RNA therapeutics: Current status and the role of in vivo imaging by Jung, Han Na, Lee, Seok-Yong, Lee, Somin, Youn, Hyewon, Im, Hyung-Jun

“…Lipid nanoparticles (LNPs) have been one of the most successful nano-delivery vehicles that enable efficient delivery of cytotoxic chemotherapy agents,…”
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Chemical logic of MraY inhibition by antibacterial nucleoside natural products by Mashalidis, Ellene H., Kaeser, Benjamin, Terasawa, Yuma, Katsuyama, Akira, Kwon, Do-Yeon, Lee, Kiyoun, Hong, Jiyong, Ichikawa, Satoshi, Lee, Seok-Yong

“…Novel antibacterial agents are needed to address the emergence of global antibiotic resistance. MraY is a promising candidate for antibiotic development…”
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Social isolation impairs the prefrontal-nucleus accumbens circuit subserving social recognition in mice by Park, Gaeun, Ryu, Changhyeon, Kim, Soobin, Jeong, Se Jin, Koo, Ja Wook, Lee, Yong-Seok, Kim, Sang Jeong

“…Although medial prefrontal cortex (mPFC) is known to play important roles in social behaviors, how early social experiences affect the mPFC and its subcortical…”
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Visualizing conformation transitions of the Lipid II flippase MurJ by Kuk, Alvin C. Y., Hao, Aili, Guan, Ziqiang, Lee, Seok-Yong

“…The biosynthesis of many polysaccharides, including bacterial peptidoglycan and eukaryotic N-linked glycans, requires transport of lipid-linked oligosaccharide…”
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The impact of RASopathy-associated mutations on CNS development in mice and humans by Kang, Minkyung, Lee, Yong-Seok

“…The RAS signaling pathway is involved in the regulation of developmental processes, including cell growth, proliferation, and differentiation, in the central…”
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Effect of icatibant on angiotensin‐converting enzyme inhibitor‐induced angioedema: A meta‐analysis of randomized controlled trials by Jeon, Jinyoung, Lee, Yun Jeong, Lee, Seok‐Yong

“…What is known and objective Angioedema (AE) caused by angiotensin‐converting enzyme inhibitors (ACEIs) requires prompt and appropriate management, but current…”
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Current view on regulation of voltage‐gated sodium channels by calcium and auxiliary proteins by Pitt, Geoffrey S., Lee, Seok‐Yong

“…In cardiac and skeletal myocytes, and in most neurons, the opening of voltage‐gated Na+ channels (NaV channels) triggers action potentials, a process that is…”
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Homocysteine as a Predictor of Early Neurological Deterioration in Acute Ischemic Stroke by KWON, Hyung-Min, LEE, Yong-Seok, BAE, Hee-Joon, KANG, Dong-Wha

“…Hyperhomocysteinemia is a well-known risk factor for vascular disease. However, its action, mechanism, and role in the acute phase of stroke have not been…”
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