Search Results - "Seok, Sang‐Hyuk"
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In vivo CRISPR–Cas9 knockout screening using quantitative PCR identifies thymosin beta‐4 X‐linked that promotes diffuse‐type gastric cancer metastasis
Published in Molecular carcinogenesis (01-09-2021)“…Gastric cancer (GC) is histologically classified into intestinal‐type gastric cancer (IGC) and diffuse‐type gastric cancer (DGC), and the latter is poorly…”
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Development of a neutralization monoclonal antibody with a broad neutralizing effect against SARS-CoV-2 variants
Published in Virology journal (01-12-2023)“…The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants has challenged the effectiveness of current therapeutic regimens. Here,…”
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Temporal Transcriptome Analysis of SARS-CoV-2-Infected Lung and Spleen in Human ACE2-Transgenic Mice
Published in Molecules and cells (31-12-2022)“…Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a highly transmissible and potentially fatal virus. So far, most comprehensive analyses…”
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A synergistic partnership between IL-33/ST2 and Wnt pathway through Bcl-xL drives gastric cancer stemness and metastasis
Published in Oncogene (10-02-2023)“…ST2 functions as a receptor for the cytokine IL-33. It has been implicated in carcinogenesis. In this study, we sought to mechanistically determine how ST2 and…”
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Rapid discovery and classification of inhibitors of coronavirus infection by pseudovirus screen and amplified luminescence proximity homogeneous assay
Published in Antiviral research (01-01-2023)“…To identify potent antiviral compounds, we introduced a high-throughput screen platform that can rapidly classify hit compounds according to their target. In…”
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Comparison of the pathogenesis of SARS-CoV-2 infection in K18-hACE2 mouse and Syrian golden hamster models
Published in Disease models & mechanisms (01-11-2022)“…ABSTRACT Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the etiological agent of COVID-19, causes life-threatening disease. This novel…”
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Mouse models of lung-specific SARS-CoV-2 infection with moderate pathological traits
Published in Frontiers in immunology (15-11-2022)“…Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causing coronavirus disease 2019 (COVID-19) has been a global health concern since 2019. The viral…”
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Establishment of multicenter COVID-19 therapeutics preclinical test system in Republic of Korea
Published in Pulmonary pharmacology & therapeutics (01-06-2023)“…Throughout the recent COVID-19 pandemic, South Korea led national efforts to develop vaccines and therapeutics for SARS-CoV-2. The project proceeded as…”
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Corrigendum: Mouse models of lung-specific SARS-CoV-2 infection with moderate pathological traits
Published in Frontiers in immunology (02-12-2022)“…[This corrects the article DOI: 10.3389/fimmu.2022.1055811.]…”
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A longitudinal molecular and cellular lung atlas of lethal SARS-CoV-2 infection in K18-hACE2 transgenic mice
Published in EBioMedicine (01-01-2024)“…The global pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has led to approximately 500 million cases and 6 million deaths…”
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Laboratory information management system for COVID-19 non-clinical efficacy trial data
Published in Laboratory animal research (28-06-2022)“…Abstract Background As the number of large-scale studies involving multiple organizations producing data has steadily increased, an integrated system for a…”
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A longitudinal molecular and cellular lung atlas of lethal SARS-CoV-2 infection in K18-hACE2 transgenic miceResearch in context
Published in EBioMedicine (01-01-2024)“…Background: The global pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has led to approximately 500 million cases and 6 million…”
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Immune Cells Are Differentially Affected by SARS-CoV-2 Viral Loads in K18-hACE2 Mice
Published in Immune network (01-04-2024)“…Viral load and the duration of viral shedding of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are important determinants of the transmission of…”
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Serum measurements of testosterone, insulin-like growth factor 1, and insulin-like growth factor binding protein-3 in the diagnosis of prostate cancer among Korean men
Published in Asian journal of andrology (01-03-2008)“…Aim: To investigate the relationships of serum testosterone, insulin-like growth factor (IGF)- 1 and IGF-binding protein (IGFBP)-3 levels with prostate cancer…”
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