Search Results - "Seoane, Jose"

Quantitative evidence for early metastatic seeding in colorectal cancer by Hu, Zheng, Ding, Jie, Ma, Zhicheng, Sun, Ruping, Seoane, Jose A., Scott Shaffer, J., Suarez, Carlos J., Berghoff, Anna S., Cremolini, Chiara, Falcone, Alfredo, Loupakis, Fotios, Birner, Peter, Preusser, Matthias, Lenz, Heinz-Josef, Curtis, Christina

“…Both the timing and molecular determinants of metastasis are unknown, hindering treatment and prevention efforts. Here we characterize the evolutionary…”
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Dynamics of breast-cancer relapse reveal late-recurring ER-positive genomic subgroups by Rueda, Oscar M., Sammut, Stephen-John, Seoane, Jose A., Chin, Suet-Feung, Caswell-Jin, Jennifer L., Callari, Maurizio, Batra, Rajbir, Pereira, Bernard, Bruna, Alejandra, Ali, H. Raza, Provenzano, Elena, Liu, Bin, Parisien, Michelle, Gillett, Cheryl, McKinney, Steven, Green, Andrew R., Murphy, Leigh, Purushotham, Arnie, Ellis, Ian O., Pharoah, Paul D., Rueda, Cristina, Aparicio, Samuel, Caldas, Carlos, Curtis, Christina

“…The rates and routes of lethal systemic spread in breast cancer are poorly understood owing to a lack of molecularly characterized patient cohorts with…”
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CRISPR screens in cancer spheroids identify 3D growth-specific vulnerabilities by Han, Kyuho, Pierce, Sarah E., Li, Amy, Spees, Kaitlyn, Anderson, Gray R., Seoane, Jose A., Lo, Yuan-Hung, Dubreuil, Michael, Olivas, Micah, Kamber, Roarke A., Wainberg, Michael, Kostyrko, Kaja, Kelly, Marcus R., Yousefi, Maryam, Simpkins, Scott W., Yao, David, Lee, Keonil, Kuo, Calvin J., Jackson, Peter K., Sweet-Cordero, Alejandro, Kundaje, Anshul, Gentles, Andrew J., Curtis, Christina, Winslow, Monte M., Bassik, Michael C.

“…Cancer genomics studies have identified thousands of putative cancer driver genes 1 . Development of high-throughput and accurate models to define the…”
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Cell of Origin Influences Pancreatic Cancer Subtype by Flowers, Brittany M, Xu, Hang, Mulligan, Abigail S, Hanson, Kathryn J, Seoane, Jose A, Vogel, Hannes, Curtis, Christina, Wood, Laura D, Attardi, Laura D

“…Pancreatic ductal adenocarcinoma (PDAC) is a deadly disease with a 5-year survival rate of approximately 9%. An improved understanding of PDAC initiation and…”
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Inter-cellular CRISPR screens reveal regulators of cancer cell phagocytosis by Kamber, Roarke A., Nishiga, Yoko, Morton, Bhek, Banuelos, Allison M., Barkal, Amira A., Vences-Catalán, Felipe, Gu, Mingxin, Fernandez, Daniel, Seoane, Jose A., Yao, David, Liu, Katherine, Lin, Sijie, Spees, Kaitlyn, Curtis, Christina, Jerby-Arnon, Livnat, Weissman, Irving L., Sage, Julien, Bassik, Michael C.

“…Monoclonal antibody therapies targeting tumour antigens drive cancer cell elimination in large part by triggering macrophage phagocytosis of cancer cells 1 – 7…”
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The chromatin accessibility landscape of primary human cancers by Corces, M Ryan, Granja, Jeffrey M, Shams, Shadi, Louie, Bryan H, Seoane, Jose A, Zhou, Wanding, Silva, Tiago C, Groeneveld, Clarice, Wong, Christopher K, Cho, Seung Woo, Satpathy, Ansuman T, Mumbach, Maxwell R, Hoadley, Katherine A, Robertson, A Gordon, Sheffield, Nathan C, Felau, Ina, Castro, Mauro A A, Berman, Benjamin P, Staudt, Louis M, Zenklusen, Jean C, Laird, Peter W, Curtis, Christina, Greenleaf, William J, Chang, Howard Y

“…We present the genome-wide chromatin accessibility profiles of 410 tumor samples spanning 23 cancer types from The Cancer Genome Atlas (TCGA). We identify…”
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Increased production of L-serine in Escherichia coli through Adaptive Laboratory Evolution by Mundhada, Hemanshu, Seoane, Jose M., Schneider, Konstantin, Koza, Anna, Christensen, Hanne B., Klein, Tobias, Phaneuf, Patrick V., Herrgard, Markus, Feist, Adam M., Nielsen, Alex T.

“…L-serine is a promising building block biochemical with a high theoretical production yield from glucose. Toxicity of L-serine is however prohibitive for…”
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A CRISPR/Cas9-Engineered ARID1A -Deficient Human Gastric Cancer Organoid Model Reveals Essential and Nonessential Modes of Oncogenic Transformation by Lo, Yuan-Hung, Kolahi, Kevin S, Du, Yuhong, Chang, Chiung-Ying, Krokhotin, Andrey, Nair, Ajay, Sobba, Walter D, Karlsson, Kasper, Jones, Sunny J, Longacre, Teri A, Mah, Amanda T, Tercan, Bahar, Sockell, Alexandra, Xu, Hang, Seoane, Jose A, Chen, Jin, Shmulevich, Ilya, Weissman, Jonathan S, Curtis, Christina, Califano, Andrea, Fu, Haian, Crabtree, Gerald R, Kuo, Calvin J

“…Mutations in rank among the most common molecular aberrations in human cancer. However, oncogenic consequences of mutation in human cells remain poorly defined…”
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The AMBRA1 E3 ligase adaptor regulates the stability of cyclin D by Chaikovsky, Andrea C., Li, Chuan, Jeng, Edwin E., Loebell, Samuel, Lee, Myung Chang, Murray, Christopher W., Cheng, Ran, Demeter, Janos, Swaney, Danielle L., Chen, Si-Han, Newton, Billy W., Johnson, Jeffrey R., Drainas, Alexandros P., Shue, Yan Ting, Seoane, Jose A., Srinivasan, Preethi, He, Andy, Yoshida, Akihiro, Hipkins, Susan Q., McCrea, Edel, Poltorack, Carson D., Krogan, Nevan J., Diehl, J. Alan, Kong, Christina, Jackson, Peter K., Curtis, Christina, Petrov, Dmitri A., Bassik, Michael C., Winslow, Monte M., Sage, Julien

“…The initiation of cell division integrates a large number of intra- and extracellular inputs. D-type cyclins (hereafter, cyclin D) couple these inputs to the…”
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Mapping the in vivo fitness landscape of lung adenocarcinoma tumor suppression in mice by Rogers, Zoë N., McFarland, Christopher D., Winters, Ian P., Seoane, Jose A., Brady, Jennifer J., Yoon, Stephanie, Curtis, Christina, Petrov, Dmitri A., Winslow, Monte M.

“…The functional impact of most genomic alterations found in cancer, alone or in combination, remains largely unknown. Here we integrate tumor barcoding,…”
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Rainfall decrease and red deer rutting behaviour: Weaker and delayed rutting activity though higher opportunity for sexual selection by F Millán, Marina, Carranza, Juan, Pérez-González, Javier, Valencia, Juliana, Torres-Porras, Jerónimo, Seoane, Jose M, de la Peña, Eva, Alarcos, Susana, Sánchez-Prieto, Cristina B, Castillo, Leticia, Flores, Antonio, Membrillo, Alberto

“…In the last decades, climate change has caused an increase in mean temperatures and a reduction in average rainfall in southern Europe, which is expected to…”
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Zmat3 Is a Key Splicing Regulator in the p53 Tumor Suppression Program by Bieging-Rolett, Kathryn T., Kaiser, Alyssa M., Morgens, David W., Boutelle, Anthony M., Seoane, Jose A., Van Nostrand, Eric L., Zhu, Changyu, Houlihan, Shauna L., Mello, Stephano S., Yee, Brian A., McClendon, Jacob, Pierce, Sarah E., Winters, Ian P., Wang, Mengxiong, Connolly, Andrew J., Lowe, Scott W., Curtis, Christina, Yeo, Gene W., Winslow, Monte M., Bassik, Michael C., Attardi, Laura D.

“…Although TP53 is the most commonly mutated gene in human cancers, the p53-dependent transcriptional programs mediating tumor suppression remain incompletely…”
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Metabolic Profiling Reveals a Dependency of Human Metastatic Breast Cancer on Mitochondrial Serine and One-Carbon Unit Metabolism by Li, Albert M, Ducker, Gregory S, Li, Yang, Seoane, Jose A, Xiao, Yiren, Melemenidis, Stavros, Zhou, Yiren, Liu, Ling, Vanharanta, Sakari, Graves, Edward E, Rankin, Erinn B, Curtis, Christina, Massagué, Joan, Rabinowitz, Joshua D, Thompson, Craig B, Ye, Jiangbin

“…Breast cancer is the most common cancer among American women and a major cause of mortality. To identify metabolic pathways as potential targets to treat…”
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The Mettl3 epitranscriptomic writer amplifies p53 stress responses by Raj, Nitin, Wang, Mengxiong, Seoane, Jose A, Zhao, Richard L, Kaiser, Alyssa M, Moonie, Nancie A, Demeter, Janos, Boutelle, Anthony M, Kerr, Craig H, Mulligan, Abigail S, Moffatt, Clare, Zeng, Shelya X, Lu, Hua, Barna, Maria, Curtis, Christina, Chang, Howard Y, Jackson, Peter K, Attardi, Laura D

“…The p53 transcription factor drives anti-proliferative gene expression programs in response to diverse stressors, including DNA damage and oncogenic signaling…”
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Chromatin regulators mediate anthracycline sensitivity in breast cancer by Seoane, Jose A., Kirkland, Jacob G., Caswell-Jin, Jennifer L., Crabtree, Gerald R., Curtis, Christina

“…Anthracyclines are a highly effective component of curative breast cancer chemotherapy but are associated with substantial morbidity 1 , 2 . Because…”
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Machine Learning Based Microbiome Signature to Predict Inflammatory Bowel Disease Subtypes by Liñares-Blanco, Jose, Fernandez-Lozano, Carlos, Seoane, Jose A, López-Campos, Guillermo

“…Inflammatory bowel disease (IBD) is a chronic disease with unknown pathophysiological mechanisms. There is evidence of the role of microorganims in this…”
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Sea-level fluctuations and coastal evolution in the state of Rio de Janeiro, southeastern Brazil by Castro, João Wagner A, Suguio, Kenitiro, Seoane, José C S, Cunha, Aline M DA, Dias, Fabio F

“…The present paper aims to investigate the relative sea-level and the coastal evolution during the Holocene in the Rio de Janeiro coastline, based on geological…”
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Molecular classification and biomarkers of clinical outcome in breast ductal carcinoma in situ: Analysis of TBCRC 038 and RAHBT cohorts by Strand, Siri H., Rivero-Gutiérrez, Belén, Houlahan, Kathleen E., Seoane, Jose A., King, Lorraine M., Risom, Tyler, Simpson, Lunden A., Vennam, Sujay, Khan, Aziz, Cisneros, Luis, Hardman, Timothy, Harmon, Bryan, Couch, Fergus, Gallagher, Kristalyn, Kilgore, Mark, Wei, Shi, DeMichele, Angela, King, Tari, McAuliffe, Priscilla F., Nangia, Julie, Lee, Joanna, Tseng, Jennifer, Storniolo, Anna Maria, Thompson, Alastair M., Gupta, Gaorav P., Burns, Robyn, Veis, Deborah J., DeSchryver, Katherine, Zhu, Chunfang, Matusiak, Magdalena, Wang, Jason, Zhu, Shirley X., Tappenden, Jen, Ding, Daisy Yi, Zhang, Dadong, Luo, Jingqin, Jiang, Shu, Varma, Sushama, Anderson, Lauren, Straub, Cody, Srivastava, Sucheta, Curtis, Christina, Tibshirani, Rob, Angelo, Robert Michael, Hall, Allison, Owzar, Kouros, Polyak, Kornelia, Maley, Carlo, Marks, Jeffrey R., Colditz, Graham A., Hwang, E. Shelley, West, Robert B.

“…Ductal carcinoma in situ (DCIS) is the most common precursor of invasive breast cancer (IBC), with variable propensity for progression. We perform multiscale,…”
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Canonical correlation analysis for gene-based pleiotropy discovery by Seoane, Jose A, Campbell, Colin, Day, Ian N M, Casas, Juan P, Gaunt, Tom R

“…Genome-wide association studies have identified a wealth of genetic variants involved in complex traits and multifactorial diseases. There is now considerable…”
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Drug discovery and design for complex diseases through QSAR computational methods by Munteanu, Cristian R, Fernández-Blanco, Enrique, Seoane, José A, Izquierdo-Novo, Pilar, Rodríguez-Fernández, José Angel, Prieto-González, José María, Rabuñal, Juan R, Pazos, Alejandro

“…There is a need for a study of the complex diseases due to their important impact on our society. One of the solutions involves the theoretical methods which…”
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