The ameliorating effect of Rosa roxburghii against ethanol-induced psychomotor alterations in rats

The ameliorating effect of Rosa roxburghii against ethanol-induced psychomotor alterations in rats

Abstract Background: Ethanol (EtOH) is one of the oldest recreational substances known to man, primarily taken because it induces a sense of well-being (euphoric effects) and relaxation (anxiolytic effects). EtOH use entails various negative consequences. Of particular interest are EtOH-induced psyc...

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Published in:The American journal of drug and alcohol abuse Vol. 40; no. 1; pp. 75 - 81
Main Authors: dela Peña, Irene Joy I., Yoon, Seo Young, de la Peña, June Bryan, Park, Subin, Yoon, Bitna, Kim, Hee Jin, Paek, Se Hee, Seo, Yonh Ki, Moon, Byoung Seok, Cheong, Jae Hoon
Format: Journal Article
Language:English
Published: England Informa Healthcare USA, Inc 01-01-2014
Taylor & Francis
Taylor & Francis Ltd
Subjects:
Acetaldehyde
Acetaldehyde - blood
Animals
Blood
Cardiovascular system
Dose-Response Relationship, Drug
Drugs, Chinese Herbal - pharmacology
Ethanol
Ethanol - antagonists & inhibitors
Ethanol - blood
Ethanol - pharmacology
Ethyl alcohol
Exploratory Behavior - drug effects
Hanging
Hematology
Male
Motor ability
Motor Skills - drug effects
Peoples Republic of China
Physical Endurance - drug effects
psychomotor alterations
Rats
Rodents
Rosa
Rosa roxburghii
Rotarod Performance Test
Swimming
Water Supply
Well Being
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Summary:Abstract Background: Ethanol (EtOH) is one of the oldest recreational substances known to man, primarily taken because it induces a sense of well-being (euphoric effects) and relaxation (anxiolytic effects). EtOH use entails various negative consequences. Of particular interest are EtOH-induced psychomotor alterations, because of its immediate manifestation and adverse consequences. Rosa roxburghii (RR), a wild plant of Southwest China, has gained attention on account of its numerous beneficial effects on the immune, nervous, and cardiovascular systems. Objective: In the present study we assessed the effects of Rosa roxburghii (RR) on EtOH-induced psychomotor alterations in rats. Methods: Sprague Dawley rats were orally administered distilled water (control group) or ethanol (4 g/kg BW) (EtOH-group) to induce psychomotor alterations. RR extract (25, 50, and 100 mg/kg, p.o.) was administered 30 min before EtOH treatment (RR-group). EtOH-induced psychomotor alterations were evaluated in the open-field, accelerating rotarod, hanging wire, and cold swimming tests. Behavioral evaluation and hematological analysis (EtOH and acetaldehyde concentration) were done at 1, 2, 4 and 8 hours after EtOH administration. Results: The EtOH group showed psychomotor alterations as compared with the control group. These EtOH-induced psychomotor alterations were directly related to the rise in blood ethanol and acetaldehyde concentrations. Pre-treatment of RR significantly improved EtOH-induced psychomotor alterations on open-field, accelerating rotarod, hanging wire, and cold swimming tests. These improvements in psychomotor performance coincided with the decreased blood ethanol and acetaldehyde levels observed in the RR-treated group. Conclusion: These results suggest that RR has ameliorating effects against EtOH-induced psychomotor alterations.
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ISSN:0095-2990
1097-9891
DOI:10.3109/00952990.2013.846349