Search Results - "Seo, Ryushi"

Identification of potent lysophosphatidic acid receptor 5 (LPA5) antagonists as potential analgesic agents by Kawamoto, Yuichiro, Seo, Ryushi, Murai, Nobuhito, Hiyama, Hideki, Oka, Hiromasa

“…[Display omitted] Lysophosphatidic acid (LPA) plays an important role in a variety of cellular functions. In particular, LPA5 receptor is highly expressed in…”
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Fragment-Based Discovery of Pyrimido[1,2-b]indazole PDE10A Inhibitors by Chino, Ayaka, Seo, Ryushi, Amano, Yasushi, Namatame, Ichiji, Hamaguchi, Wataru, Honbou, Kazuya, Mihara, Takuma, Yamazaki, Mayako, Tomishima, Masaki, Masuda, Naoyuki

“…In this study, we report the identification of potent pyrimidoindazoles as phosphodiesterase10A (PDE10A) inhibitors by using the method of fragment-based drug…”
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Addressing phototoxicity observed in a novel series of biaryl derivatives: Discovery of potent, selective and orally active phosphodiesterase 10A inhibitor ASP9436 by Hamaguchi, Wataru, Masuda, Naoyuki, Miyamoto, Satoshi, Kikuchi, Shigetoshi, Narazaki, Fumie, Shiina, Yasuhiro, Seo, Ryushi, Amano, Yasushi, Mihara, Takuma, Moriguchi, Hiroyuki, Hattori, Kouji

“…[Display omitted] We synthesized several biaryl derivatives as PDE10A inhibitors to prevent phototoxicity of…”
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Versatile chiral synthons for 1,2-diamines: (4 S,5 S)- and (4 R,5 R)-4,5-dimethoxy-2-imidazolidinones by Seo, Ryushi, Ishizuka, Tadao, Abdel-Aziz, Alaa A.-M, Kunieda, Takehisa

“…(4 S,5 S)- and (4 R,5 R)-1-Acyl-4,5-dimethoxy-2-imidazolidinone derivatives, which are readily accessible from simple 1,3-dihydro-2-imidazolone heterocycles,…”
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Discovery of a novel orally active TRPV4 inhibitor: Part 1. Optimization from an HTS hit by Sami, Yuichi, Morita, Masataka, Kubota, Hirokazu, Hirabayashi, Ryoji, Seo, Ryushi, Nakagawa, Nobuaki

“…[Display omitted]…”
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Fragment-Based Discovery of Pyrimido[1,2-b]indazole PDE10A Inhibitors by Ayaka Chino, Ryushi Seo, Yasushi Amano, Ichiji Namatame, Wataru Hamaguchi, Kazuya Honbou, Takuma Mihara, Mayako Yamazaki, Masaki Tomishima, Naoyuki Masuda

“…In this study, we report the identification of potent pyrimidoindazoles as phosphodiesterase10A (PDE10A) inhibitors by using the method of fragment-based drug…”
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Catalytic dissymmetrization of meso-2-imidazolidinones: alternative route to chiral synthons for 1,2-diamines by Ishizuka, Tadao, Katahira, Tomokazu, Seo, Ryushi, Matsunaga, Hirofumi, Kunieda, Takehisa

“…[Display omitted] The chiral functionalization of a simple heterocycle, 1,3-dihydro-2-imidazolone, was achieved by the highly enantioselective monodeacylation…”
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