Search Results - "Seo, Naohiro"

Exosome‐mediated regulation of tumor immunology by Seo, Naohiro, Akiyoshi, Kazunari, Shiku, Hiroshi

“…Exosomes are representative extracellular vesicles (EV) derived from multivesicular endosomes (MVE) and have been described as new particles in the…”
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Activated CD8+ T cell extracellular vesicles prevent tumour progression by targeting of lesional mesenchymal cells by Seo, Naohiro, Shirakura, Yoshitaka, Tahara, Yoshiro, Momose, Fumiyasu, Harada, Naozumi, Ikeda, Hiroaki, Akiyoshi, Kazunari, Shiku, Hiroshi

“…Fibroblastic tumour stroma comprising mesenchymal stem cells (MSCs) and cancer-associated fibroblasts (CAFs) promotes the invasive and metastatic properties of…”
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Exosomes and Immune Cells by Seo, Naohiro

“…In addition to the cytokines and cytotoxic granules, exosomes have been known as the intercellular communicator and cytotoxic missile of immune cells for the…”
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Distinguishing functional exosomes and other extracellular vesicles as a nucleic acid cargo by the anion‐exchange method by Seo, Naohiro, Nakamura, Junko, Kaneda, Tsuguhiro, Tateno, Hiroaki, Shimoda, Asako, Ichiki, Takanori, Furukawa, Koichi, Hirabayashi, Jun, Akiyoshi, Kazunari, Shiku, Hiroshi

“…The development of a new large‐scale purification protocol is required for research on the reliable bioactivity and drug discovery of extracellular vesicles…”
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CAR-Modified Vγ9Vδ2 T Cells Propagated Using a Novel Bisphosphonate Prodrug for Allogeneic Adoptive Immunotherapy by Wang, Yizheng, Wang, Linan, Seo, Naohiro, Okumura, Satoshi, Hayashi, Tae, Akahori, Yasushi, Fujiwara, Hiroshi, Amaishi, Yasunori, Okamoto, Sachiko, Mineno, Junichi, Tanaka, Yoshimasa, Kato, Takuma, Shiku, Hiroshi

“…The benefits of CAR-T therapy could be expanded to the treatment of solid tumors through the use of derived autologous αβ T cell, but clinical trials of CAR-T…”
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Assessment of Surface Glycan Diversity on Extracellular Vesicles by Lectin Microarray and Glycoengineering Strategies for Drug Delivery Applications by Shimoda, Asako, Miura, Risako, Tateno, Hiroaki, Seo, Naohiro, Shiku, Hiroshi, Sawada, Shin‐ichi, Sasaki, Yoshihiro, Akiyoshi, Kazunari

“…Extracellular vesicles (EVs) are released by all types of mammalian cells for cell–cell communication. In this study, surface glycans on EVs are compared in…”
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Interleukin-17 induces an atypical M2-like macrophage subpopulation that regulates intestinal inflammation by Nishikawa, Kenichiro, Seo, Naohiro, Torii, Mie, Ma, Nei, Muraoka, Daisuke, Tawara, Isao, Masuya, Masahiro, Tanaka, Kyosuke, Takei, Yoshiyuki, Shiku, Hiroshi, Katayama, Naoyuki, Kato, Takuma

“…Interleukin 17 (IL-17) is a pleiotropic cytokine that acts on both immune and non-immune cells and is generally implicated in inflammatory and autoimmune…”
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Stimulation of human butyrophilin 3 molecules results in negative regulation of cellular immunity by Yamashiro, Hiromichi, Yoshizaki, Shinji, Tadaki, Toshimasa, Egawa, Kohji, Seo, Naohiro

“…Stimulation of butyrophilin 3 molecules by specific agonistic mAbs results in down‐regulation of proliferation and cytokine secretion in CD4 and CD8 T…”
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Guanine-Rich Sequences Are a Dominant Feature of Exosomal microRNAs across the Mammalian Species and Cell Types by Momose, Fumiyasu, Seo, Naohiro, Akahori, Yasushi, Sawada, Shin-Ichi, Harada, Naozumi, Ogura, Toru, Akiyoshi, Kazunari, Shiku, Hiroshi

“…Exosome is an extracellular vesicle released from multivesicular endosomes and contains micro (mi) RNAs and functional proteins derived from the donor cells…”
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Skin inflammation leads immunoglobulin G aggregation and deposition in multiple organs by Yamanaka, Keiichi, Okada, Karin, Nakanishi, Takehisa, Mizutani, Kento, Matsushima, Yoshiaki, Kondo, Makoto, Habe, Koji, Mizutani, Hitoshi, Seo, Naohiro

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Skin Inflammation and Testicular Function: Dermatitis Causes Male Infertility via Skin-Derived Cytokines by Umaoka, Ai, Takeuchi, Hiroki, Mizutani, Kento, Seo, Naohiro, Matsushima, Yoshiaki, Habe, Koji, Hagimori, Kohei, Yamaguchi, Yukie, Ikeda, Tomoaki, Yamanaka, Keiichi

“…The medical comorbidities including skin diseases are associated with male infertility. The most common cause of male infertility is the inability of testes to…”
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Systemic CD8+ T cell-mediated tumoricidal effects by intratumoral treatment of oncolytic herpes simplex virus with the agonistic monoclonal antibody for murine glucocorticoid-induced tumor necrosis factor receptor by Ishihara, Mikiya, Seo, Naohiro, Mitsui, Jun, Muraoka, Daisuke, Tanaka, Maki, Mineno, Junichi, Ikeda, Hiroaki, Shiku, Hiroshi

“…Oncolytic virotherapy combined with immunomodulators is a novel noninvasive strategy for cancer treatment. In this study, we examined the tumoricidal effects…”
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The current status and future direction of percutaneous peptide immunization against melanoma by Seo, Naohiro, Takigawa, Masahiro

“…Summary Dendritic cell (DC)-based tumor immunotherapy is widely known to elicit protective anti-tumor immune responses, although the safety and effectiveness…”
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Hypersensitivity to mosquito bites as the primary clinical manifestation of a juvenile type of Epstein-Barr virus-associated natural killer cell leukemia/lymphoma by Tokura, Yoshiki, Ishihara, Shigehiko, Tagawa, Shinichi, Seo, Naohiro, Ohshima, Kouichi, Takigawa, Masahiro

“…Hypersensitivity to mosquito bites or mosquito allergy is a mysterious disorder that has been reported mainly in Japanese patients (at least 58 patients) in…”
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Anti-infective and anti-tumor agents based on the depletion of immune suppressive effects by Seo, Naohiro, Yamashiro, Hiromichi, Tadaki, Toshimasa

“…Aggressive immunity characterized by the motion of cytotoxic T lymphocytes (CTLs), T helper (Th) 1 cells, and natural killer (NK) cells is the first line of…”
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Compartmental Imbalance and Aberrant Immune Function of Blood CD123+ (Plasmacytoid) and CD11c+ (Myeloid) Dendritic Cells in Atopic Dermatitis by Hashizume, Hideo, Horibe, Takahiro, Yagi, Hiroaki, Seo, Naohiro, Takigawa, Masahiro

“…Atopic dermatitis (AD) is a pruritic, chronically relapsing skin disease in which Th2 cells play a crucial role in cutaneous and extracutaneous immune…”
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Percutaneous Peptide Immunization via Corneum Barrier-Disrupted Murine Skin for Experimental Tumor Immunoprophylaxis by Seo, Naohiro, Tokura, Yoshiki, Nishijima, Takafumi, Hashizume, Hideo, Furukawa, Fukumi, Takigawa, Masahiro

“…H-2Kb-restricted tumor epitope peptides, including tyrosinase-related protein 2 residues 181-188 (TRP-2) and connexin 37 residues 52-59 (MUT1), were applied to…”
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Mechanisms of immune privilege for tumor cells by regulatory cytokines produced by innate and acquired immune cells by Seo, Naohiro, Hayakawa, Satoshi, Tokura, Yoshiki

“…In murine tumors, innate immunity act as a trigger for the development of acquired immunity. The innate immune cells, natural killer (NK) and natural T (NKT)…”
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A Novel Strategy of Cancer Gene Therapy by Transcriptional Targeting of an Allogeneic Histocompatibility Transgene by KUWADA, Eri, NOGUCHI, Katsuo, SEO, Naohiro, YAMASHIRO, Hiromichi, EGAWA, Kohji

“…Background: A drawback of cancer gene therapy is the failure of toxic gene introduction into a proportion of the tumor cells, resulting in re-progression of…”
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Anti-allergic Psidium guajava Extracts Exert an Antitumor Effect by Inhibition of T Regulatory Cells and Resultant Augmentation of Th1 Cells by SEO, Naohiro, ITO, Taisuke, NAILI WANG, XINSHENG YAO, TOKURA, Yoshiki, FURUKAWA, Fukumi, TAKIGAWA, Masahiro, KITANAKA, Susumu

“…Th1 polarization is one of the mechanisms underlying the therapeutic effects of herbal medicine. The action of anti-allergic agents from Psidium guajava (P…”
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